Subthalamic nucleus stimulation affects orbitofrontal cortex in facial emotion recognition: a pet study
Identifieur interne : 000861 ( Ncbi/Merge ); précédent : 000860; suivant : 000862Subthalamic nucleus stimulation affects orbitofrontal cortex in facial emotion recognition: a pet study
Auteurs : F. Le Jeune ; J. Péron ; I. Biseul ; S. Fournier ; P. Sauleau ; S. Drapier ; C. Haegelen ; D. Drapier ; B. Millet ; E. Garin ; J.-Y. Herry ; C.-H. Malbert [France] ; M. VérinSource :
- Brain [ 0006-8950 ] ; 2008.
English descriptors
- KwdEn :
- Case-Control Studies, Deep Brain Stimulation (adverse effects), Deep Brain Stimulation (methods), Facial Expression, Fear, Female, Fluorodeoxyglucose F18, Frontal Lobe (diagnostic imaging), Frontal Lobe (physiology), Glucose (metabolism), Humans, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (metabolism), Parkinson Disease (psychology), Parkinson Disease (therapy), Positron-Emission Tomography, Recognition (Psychology), Statistics, Nonparametric, Subthalamic Nucleus (diagnostic imaging), Subthalamic Nucleus (physiology).
- MESH :
- chemical , metabolism : Glucose.
- chemical : Fluorodeoxyglucose F18.
- adverse effects : Deep Brain Stimulation.
- diagnostic imaging : Frontal Lobe, Subthalamic Nucleus.
- metabolism : Parkinson Disease.
- methods : Deep Brain Stimulation.
- physiology : Frontal Lobe, Subthalamic Nucleus.
- psychology : Parkinson Disease.
- therapy : Parkinson Disease.
- Case-Control Studies, Facial Expression, Fear, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Positron-Emission Tomography, Recognition (Psychology), Statistics, Nonparametric.
Abstract
Deep brain stimulation (DBS) of the bilateral subthalamic nucleus (STN) in Parkinson's disease is thought to produce adverse events such as emotional disorders, and in a recent study, we found fear recognition to be impaired as a result. These changes have been attributed to disturbance of the STN's limbic territory and would appear to confirm that the negative emotion recognition network passes through the STN. In addition, it is now widely acknowledged that damage to the orbitofrontal cortex (OFC), especially the right side, can result in impaired recognition of facial emotions (RFE). In this context, we hypothesized that this reduced recognition of fear is correlated with modifications in the cerebral glucose metabolism of the right OFC. The objective of the present study was first, to reinforce our previous results by demonstrating reduced fear recognition in our Parkinson's disease patient group following STN DBS and, second, to correlate these emotional performances with glucose metabolism using 18FDG-PET. The 18FDG-PET and RFE tasks were both performed by a cohort of 13 Parkinson's disease patients 3 months before and 3 months after surgery for STN DBS. As predicted, we observed a significant reduction in fear recognition following surgery and obtained a positive correlation between these neuropsychological results and changes in glucose metabolism, especially in the right OFC. These results confirm the role of the STN as a key basal ganglia structure in limbic circuits.
Url:
DOI: 10.1093/brain/awn084
PubMed: 18490359
PubMed Central: 2408938
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Le Jeune</name><affiliation><nlm:aff id="AFF1">Service de Médecine Nucléaire, Centre Eugène Marquis, rue de la Bataille Flandres Dunkerque, 35042 Rennes,</nlm:aff><wicri:noCountry code="subfield">35042 Rennes</wicri:noCountry></affiliation><affiliation><nlm:aff id="AFF1">Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1,</nlm:aff><wicri:noCountry code="subfield">Université Rennes 1</wicri:noCountry></affiliation></author><author><name sortKey="Peron, J" sort="Peron, J" uniqKey="Peron J" first="J." last="Péron">J. Péron</name><affiliation><nlm:aff id="AFF1">Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1,</nlm:aff><wicri:noCountry code="subfield">Université Rennes 1</wicri:noCountry></affiliation><affiliation><nlm:aff id="AFF1">Clinique neurologique,</nlm:aff></affiliation></author><author><name sortKey="Biseul, I" sort="Biseul, I" uniqKey="Biseul I" first="I." last="Biseul">I. 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Sauleau</name><affiliation><nlm:aff id="AFF1">Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1,</nlm:aff><wicri:noCountry code="subfield">Université Rennes 1</wicri:noCountry></affiliation><affiliation><nlm:aff id="AFF1">Service des Explorations Fonctionnelles,</nlm:aff></affiliation></author><author><name sortKey="Drapier, S" sort="Drapier, S" uniqKey="Drapier S" first="S." last="Drapier">S. Drapier</name><affiliation><nlm:aff id="AFF1">Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1,</nlm:aff><wicri:noCountry code="subfield">Université Rennes 1</wicri:noCountry></affiliation><affiliation><nlm:aff id="AFF1">Clinique neurologique,</nlm:aff></affiliation></author><author><name sortKey="Haegelen, C" sort="Haegelen, C" uniqKey="Haegelen C" first="C." last="Haegelen">C. Haegelen</name><affiliation><nlm:aff id="AFF1">Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1,</nlm:aff><wicri:noCountry code="subfield">Université Rennes 1</wicri:noCountry></affiliation><affiliation><nlm:aff id="AFF1">Service de Neurochirurgie, Hôpital Pontchaillou, CHU de Rennes, rue Henri Le Guilloux, 35033 Rennes,</nlm:aff><wicri:noCountry code="subfield">35033 Rennes</wicri:noCountry></affiliation></author><author><name sortKey="Drapier, D" sort="Drapier, D" uniqKey="Drapier D" first="D." last="Drapier">D. Drapier</name><affiliation><nlm:aff id="AFF1">Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1,</nlm:aff><wicri:noCountry code="subfield">Université Rennes 1</wicri:noCountry></affiliation><affiliation><nlm:aff wicri:cut=" and" id="AFF1">S.H.U. Psychiatrie Adulte, CH Guillaume Régnier, 108 avenue du Général Leclerc, 35703 Rennes</nlm:aff><wicri:noCountry code="subfield">35703 Rennes</wicri:noCountry></affiliation></author><author><name sortKey="Millet, B" sort="Millet, B" uniqKey="Millet B" first="B." last="Millet">B. Millet</name><affiliation><nlm:aff id="AFF1">Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1,</nlm:aff><wicri:noCountry code="subfield">Université Rennes 1</wicri:noCountry></affiliation><affiliation><nlm:aff wicri:cut=" and" id="AFF1">S.H.U. Psychiatrie Adulte, CH Guillaume Régnier, 108 avenue du Général Leclerc, 35703 Rennes</nlm:aff><wicri:noCountry code="subfield">35703 Rennes</wicri:noCountry></affiliation></author><author><name sortKey="Garin, E" sort="Garin, E" uniqKey="Garin E" first="E." last="Garin">E. Garin</name><affiliation><nlm:aff id="AFF1">Service de Médecine Nucléaire, Centre Eugène Marquis, rue de la Bataille Flandres Dunkerque, 35042 Rennes,</nlm:aff><wicri:noCountry code="subfield">35042 Rennes</wicri:noCountry></affiliation></author><author><name sortKey="Herry, J Y" sort="Herry, J Y" uniqKey="Herry J" first="J.-Y." last="Herry">J.-Y. Herry</name><affiliation><nlm:aff id="AFF1">Service de Médecine Nucléaire, Centre Eugène Marquis, rue de la Bataille Flandres Dunkerque, 35042 Rennes,</nlm:aff><wicri:noCountry code="subfield">35042 Rennes</wicri:noCountry></affiliation></author><author><name sortKey="Malbert, C H" sort="Malbert, C H" uniqKey="Malbert C" first="C.-H." last="Malbert">C.-H. Malbert</name><affiliation wicri:level="3"><nlm:aff id="AFF1">UMR SENAH, Ingestive Behaviour Department, 35590 Saint Gilles, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR SENAH, Ingestive Behaviour Department, 35590 Saint Gilles</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Saint Gilles</settlement></placeName></affiliation></author><author><name sortKey="Verin, M" sort="Verin, M" uniqKey="Verin M" first="M." last="Vérin">M. Vérin</name><affiliation><nlm:aff id="AFF1">Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1,</nlm:aff><wicri:noCountry code="subfield">Université Rennes 1</wicri:noCountry></affiliation><affiliation><nlm:aff id="AFF1">Clinique neurologique,</nlm:aff></affiliation></author></analytic><series><title level="j">Brain</title><idno type="ISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Case-Control Studies</term><term>Deep Brain Stimulation (adverse effects)</term><term>Deep Brain Stimulation (methods)</term><term>Facial Expression</term><term>Fear</term><term>Female</term><term>Fluorodeoxyglucose F18</term><term>Frontal Lobe (diagnostic imaging)</term><term>Frontal Lobe (physiology)</term><term>Glucose (metabolism)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (psychology)</term><term>Parkinson Disease (therapy)</term><term>Positron-Emission Tomography</term><term>Recognition (Psychology)</term><term>Statistics, Nonparametric</term><term>Subthalamic Nucleus (diagnostic imaging)</term><term>Subthalamic Nucleus (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glucose</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Fluorodeoxyglucose F18</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Frontal Lobe</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Frontal Lobe</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term><term>Facial Expression</term><term>Fear</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Positron-Emission Tomography</term><term>Recognition (Psychology)</term><term>Statistics, Nonparametric</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Deep brain stimulation (DBS) of the bilateral subthalamic nucleus (STN) in Parkinson's disease is thought to produce adverse events such as emotional disorders, and in a recent study, we found fear recognition to be impaired as a result. These changes have been attributed to disturbance of the STN's limbic territory and would appear to confirm that the negative emotion recognition network passes through the STN. In addition, it is now widely acknowledged that damage to the orbitofrontal cortex (OFC), especially the right side, can result in impaired recognition of facial emotions (RFE). In this context, we hypothesized that this reduced recognition of fear is correlated with modifications in the cerebral glucose metabolism of the right OFC. The objective of the present study was first, to reinforce our previous results by demonstrating reduced fear recognition in our Parkinson's disease patient group following STN DBS and, second, to correlate these emotional performances with glucose metabolism using <sup>18</sup>FDG-PET. The <sup>18</sup>FDG-PET and RFE tasks were both performed by a cohort of 13 Parkinson's disease patients 3 months before and 3 months after surgery for STN DBS. As predicted, we observed a significant reduction in fear recognition following surgery and obtained a positive correlation between these neuropsychological results and changes in glucose metabolism, especially in the right OFC. These results confirm the role of the STN as a key basal ganglia structure in limbic circuits.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><double pmid="18490359"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Subthalamic nucleus stimulation affects orbitofrontal cortex in facial emotion recognition: a pet study</title><author><name sortKey="Le Jeune, F" sort="Le Jeune, F" uniqKey="Le Jeune F" first="F." last="Le Jeune">F. Le Jeune</name><affiliation><nlm:aff id="AFF1">Service de Médecine Nucléaire, Centre Eugène Marquis, rue de la Bataille Flandres Dunkerque, 35042 Rennes,</nlm:aff><wicri:noCountry code="subfield">35042 Rennes</wicri:noCountry></affiliation><affiliation><nlm:aff id="AFF1">Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1,</nlm:aff><wicri:noCountry code="subfield">Université Rennes 1</wicri:noCountry></affiliation></author><author><name sortKey="Peron, J" sort="Peron, J" uniqKey="Peron J" first="J." last="Péron">J. Péron</name><affiliation><nlm:aff id="AFF1">Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1,</nlm:aff><wicri:noCountry code="subfield">Université Rennes 1</wicri:noCountry></affiliation><affiliation><nlm:aff id="AFF1">Clinique neurologique,</nlm:aff></affiliation></author><author><name sortKey="Biseul, I" sort="Biseul, I" uniqKey="Biseul I" first="I." last="Biseul">I. Biseul</name><affiliation><nlm:aff id="AFF1">Clinique neurologique,</nlm:aff></affiliation></author><author><name sortKey="Fournier, S" sort="Fournier, S" uniqKey="Fournier S" first="S." last="Fournier">S. Fournier</name><affiliation><nlm:aff id="AFF1">Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1,</nlm:aff><wicri:noCountry code="subfield">Université Rennes 1</wicri:noCountry></affiliation><affiliation><nlm:aff id="AFF1">Clinique neurologique,</nlm:aff></affiliation></author><author><name sortKey="Sauleau, P" sort="Sauleau, P" uniqKey="Sauleau P" first="P." last="Sauleau">P. Sauleau</name><affiliation><nlm:aff id="AFF1">Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1,</nlm:aff><wicri:noCountry code="subfield">Université Rennes 1</wicri:noCountry></affiliation><affiliation><nlm:aff id="AFF1">Service des Explorations Fonctionnelles,</nlm:aff></affiliation></author><author><name sortKey="Drapier, S" sort="Drapier, S" uniqKey="Drapier S" first="S." last="Drapier">S. Drapier</name><affiliation><nlm:aff id="AFF1">Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1,</nlm:aff><wicri:noCountry code="subfield">Université Rennes 1</wicri:noCountry></affiliation><affiliation><nlm:aff id="AFF1">Clinique neurologique,</nlm:aff></affiliation></author><author><name sortKey="Haegelen, C" sort="Haegelen, C" uniqKey="Haegelen C" first="C." last="Haegelen">C. Haegelen</name><affiliation><nlm:aff id="AFF1">Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1,</nlm:aff><wicri:noCountry code="subfield">Université Rennes 1</wicri:noCountry></affiliation><affiliation><nlm:aff id="AFF1">Service de Neurochirurgie, Hôpital Pontchaillou, CHU de Rennes, rue Henri Le Guilloux, 35033 Rennes,</nlm:aff><wicri:noCountry code="subfield">35033 Rennes</wicri:noCountry></affiliation></author><author><name sortKey="Drapier, D" sort="Drapier, D" uniqKey="Drapier D" first="D." last="Drapier">D. Drapier</name><affiliation><nlm:aff id="AFF1">Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1,</nlm:aff><wicri:noCountry code="subfield">Université Rennes 1</wicri:noCountry></affiliation><affiliation><nlm:aff wicri:cut=" and" id="AFF1">S.H.U. Psychiatrie Adulte, CH Guillaume Régnier, 108 avenue du Général Leclerc, 35703 Rennes</nlm:aff><wicri:noCountry code="subfield">35703 Rennes</wicri:noCountry></affiliation></author><author><name sortKey="Millet, B" sort="Millet, B" uniqKey="Millet B" first="B." last="Millet">B. Millet</name><affiliation><nlm:aff id="AFF1">Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1,</nlm:aff><wicri:noCountry code="subfield">Université Rennes 1</wicri:noCountry></affiliation><affiliation><nlm:aff wicri:cut=" and" id="AFF1">S.H.U. Psychiatrie Adulte, CH Guillaume Régnier, 108 avenue du Général Leclerc, 35703 Rennes</nlm:aff><wicri:noCountry code="subfield">35703 Rennes</wicri:noCountry></affiliation></author><author><name sortKey="Garin, E" sort="Garin, E" uniqKey="Garin E" first="E." last="Garin">E. Garin</name><affiliation><nlm:aff id="AFF1">Service de Médecine Nucléaire, Centre Eugène Marquis, rue de la Bataille Flandres Dunkerque, 35042 Rennes,</nlm:aff><wicri:noCountry code="subfield">35042 Rennes</wicri:noCountry></affiliation></author><author><name sortKey="Herry, J Y" sort="Herry, J Y" uniqKey="Herry J" first="J.-Y." last="Herry">J.-Y. Herry</name><affiliation><nlm:aff id="AFF1">Service de Médecine Nucléaire, Centre Eugène Marquis, rue de la Bataille Flandres Dunkerque, 35042 Rennes,</nlm:aff><wicri:noCountry code="subfield">35042 Rennes</wicri:noCountry></affiliation></author><author><name sortKey="Malbert, C H" sort="Malbert, C H" uniqKey="Malbert C" first="C.-H." last="Malbert">C.-H. Malbert</name><affiliation wicri:level="3"><nlm:aff id="AFF1">UMR SENAH, Ingestive Behaviour Department, 35590 Saint Gilles, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR SENAH, Ingestive Behaviour Department, 35590 Saint Gilles</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Saint Gilles</settlement></placeName></affiliation></author><author><name sortKey="Verin, M" sort="Verin, M" uniqKey="Verin M" first="M." last="Vérin">M. Vérin</name><affiliation><nlm:aff id="AFF1">Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1,</nlm:aff><wicri:noCountry code="subfield">Université Rennes 1</wicri:noCountry></affiliation><affiliation><nlm:aff id="AFF1">Clinique neurologique,</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18490359</idno><idno type="pmc">2408938</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408938</idno><idno type="RBID">PMC:2408938</idno><idno type="doi">10.1093/brain/awn084</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">000388</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000388</idno><idno type="wicri:Area/Pmc/Curation">000385</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000385</idno><idno type="wicri:Area/Pmc/Checkpoint">000836</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000836</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Subthalamic nucleus stimulation affects orbitofrontal cortex in facial emotion recognition: a pet study</title><author><name sortKey="Le Jeune, F" sort="Le Jeune, F" uniqKey="Le Jeune F" first="F." last="Le Jeune">F. Le Jeune</name><affiliation><nlm:aff id="AFF1">Service de Médecine Nucléaire, Centre Eugène Marquis, rue de la Bataille Flandres Dunkerque, 35042 Rennes,</nlm:aff><wicri:noCountry code="subfield">35042 Rennes</wicri:noCountry></affiliation><affiliation><nlm:aff id="AFF1">Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1,</nlm:aff><wicri:noCountry code="subfield">Université Rennes 1</wicri:noCountry></affiliation></author><author><name sortKey="Peron, J" sort="Peron, J" uniqKey="Peron J" first="J." last="Péron">J. Péron</name><affiliation><nlm:aff id="AFF1">Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1,</nlm:aff><wicri:noCountry code="subfield">Université Rennes 1</wicri:noCountry></affiliation><affiliation><nlm:aff id="AFF1">Clinique neurologique,</nlm:aff></affiliation></author><author><name sortKey="Biseul, I" sort="Biseul, I" uniqKey="Biseul I" first="I." last="Biseul">I. Biseul</name><affiliation><nlm:aff id="AFF1">Clinique neurologique,</nlm:aff></affiliation></author><author><name sortKey="Fournier, S" sort="Fournier, S" uniqKey="Fournier S" first="S." last="Fournier">S. Fournier</name><affiliation><nlm:aff id="AFF1">Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1,</nlm:aff><wicri:noCountry code="subfield">Université Rennes 1</wicri:noCountry></affiliation><affiliation><nlm:aff id="AFF1">Clinique neurologique,</nlm:aff></affiliation></author><author><name sortKey="Sauleau, P" sort="Sauleau, P" uniqKey="Sauleau P" first="P." last="Sauleau">P. Sauleau</name><affiliation><nlm:aff id="AFF1">Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1,</nlm:aff><wicri:noCountry code="subfield">Université Rennes 1</wicri:noCountry></affiliation><affiliation><nlm:aff id="AFF1">Service des Explorations Fonctionnelles,</nlm:aff></affiliation></author><author><name sortKey="Drapier, S" sort="Drapier, S" uniqKey="Drapier S" first="S." last="Drapier">S. Drapier</name><affiliation><nlm:aff id="AFF1">Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1,</nlm:aff><wicri:noCountry code="subfield">Université Rennes 1</wicri:noCountry></affiliation><affiliation><nlm:aff id="AFF1">Clinique neurologique,</nlm:aff></affiliation></author><author><name sortKey="Haegelen, C" sort="Haegelen, C" uniqKey="Haegelen C" first="C." last="Haegelen">C. Haegelen</name><affiliation><nlm:aff id="AFF1">Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1,</nlm:aff><wicri:noCountry code="subfield">Université Rennes 1</wicri:noCountry></affiliation><affiliation><nlm:aff id="AFF1">Service de Neurochirurgie, Hôpital Pontchaillou, CHU de Rennes, rue Henri Le Guilloux, 35033 Rennes,</nlm:aff><wicri:noCountry code="subfield">35033 Rennes</wicri:noCountry></affiliation></author><author><name sortKey="Drapier, D" sort="Drapier, D" uniqKey="Drapier D" first="D." last="Drapier">D. Drapier</name><affiliation><nlm:aff id="AFF1">Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1,</nlm:aff><wicri:noCountry code="subfield">Université Rennes 1</wicri:noCountry></affiliation><affiliation><nlm:aff wicri:cut=" and" id="AFF1">S.H.U. Psychiatrie Adulte, CH Guillaume Régnier, 108 avenue du Général Leclerc, 35703 Rennes</nlm:aff><wicri:noCountry code="subfield">35703 Rennes</wicri:noCountry></affiliation></author><author><name sortKey="Millet, B" sort="Millet, B" uniqKey="Millet B" first="B." last="Millet">B. Millet</name><affiliation><nlm:aff id="AFF1">Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1,</nlm:aff><wicri:noCountry code="subfield">Université Rennes 1</wicri:noCountry></affiliation><affiliation><nlm:aff wicri:cut=" and" id="AFF1">S.H.U. Psychiatrie Adulte, CH Guillaume Régnier, 108 avenue du Général Leclerc, 35703 Rennes</nlm:aff><wicri:noCountry code="subfield">35703 Rennes</wicri:noCountry></affiliation></author><author><name sortKey="Garin, E" sort="Garin, E" uniqKey="Garin E" first="E." last="Garin">E. Garin</name><affiliation><nlm:aff id="AFF1">Service de Médecine Nucléaire, Centre Eugène Marquis, rue de la Bataille Flandres Dunkerque, 35042 Rennes,</nlm:aff><wicri:noCountry code="subfield">35042 Rennes</wicri:noCountry></affiliation></author><author><name sortKey="Herry, J Y" sort="Herry, J Y" uniqKey="Herry J" first="J.-Y." last="Herry">J.-Y. Herry</name><affiliation><nlm:aff id="AFF1">Service de Médecine Nucléaire, Centre Eugène Marquis, rue de la Bataille Flandres Dunkerque, 35042 Rennes,</nlm:aff><wicri:noCountry code="subfield">35042 Rennes</wicri:noCountry></affiliation></author><author><name sortKey="Malbert, C H" sort="Malbert, C H" uniqKey="Malbert C" first="C.-H." last="Malbert">C.-H. Malbert</name><affiliation wicri:level="3"><nlm:aff id="AFF1">UMR SENAH, Ingestive Behaviour Department, 35590 Saint Gilles, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR SENAH, Ingestive Behaviour Department, 35590 Saint Gilles</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Saint Gilles</settlement></placeName></affiliation></author><author><name sortKey="Verin, M" sort="Verin, M" uniqKey="Verin M" first="M." last="Vérin">M. Vérin</name><affiliation><nlm:aff id="AFF1">Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1,</nlm:aff><wicri:noCountry code="subfield">Université Rennes 1</wicri:noCountry></affiliation><affiliation><nlm:aff id="AFF1">Clinique neurologique,</nlm:aff></affiliation></author></analytic><series><title level="j">Brain</title><idno type="ISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Deep brain stimulation (DBS) of the bilateral subthalamic nucleus (STN) in Parkinson's disease is thought to produce adverse events such as emotional disorders, and in a recent study, we found fear recognition to be impaired as a result. These changes have been attributed to disturbance of the STN's limbic territory and would appear to confirm that the negative emotion recognition network passes through the STN. In addition, it is now widely acknowledged that damage to the orbitofrontal cortex (OFC), especially the right side, can result in impaired recognition of facial emotions (RFE). In this context, we hypothesized that this reduced recognition of fear is correlated with modifications in the cerebral glucose metabolism of the right OFC. The objective of the present study was first, to reinforce our previous results by demonstrating reduced fear recognition in our Parkinson's disease patient group following STN DBS and, second, to correlate these emotional performances with glucose metabolism using <sup>18</sup>FDG-PET. The <sup>18</sup>FDG-PET and RFE tasks were both performed by a cohort of 13 Parkinson's disease patients 3 months before and 3 months after surgery for STN DBS. As predicted, we observed a significant reduction in fear recognition following surgery and obtained a positive correlation between these neuropsychological results and changes in glucose metabolism, especially in the right OFC. These results confirm the role of the STN as a key basal ganglia structure in limbic circuits.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Subthalamic nucleus stimulation affects orbitofrontal cortex in facial emotion recognition: a PET study.</title><author><name sortKey="Le Jeune, F" sort="Le Jeune, F" uniqKey="Le Jeune F" first="F" last="Le Jeune">F. Le Jeune</name><affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Nucléaire, Centre Eugène Marquis, rue de la Bataille Flandres Dunkerque, 35042 Rennes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Médecine Nucléaire, Centre Eugène Marquis, rue de la Bataille Flandres Dunkerque, 35042 Rennes</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Peron, J" sort="Peron, J" uniqKey="Peron J" first="J" last="Péron">J. Péron</name></author><author><name sortKey="Biseul, I" sort="Biseul, I" uniqKey="Biseul I" first="I" last="Biseul">I. Biseul</name></author><author><name sortKey="Fournier, S" sort="Fournier, S" uniqKey="Fournier S" first="S" last="Fournier">S. Fournier</name></author><author><name sortKey="Sauleau, P" sort="Sauleau, P" uniqKey="Sauleau P" first="P" last="Sauleau">P. Sauleau</name></author><author><name sortKey="Drapier, S" sort="Drapier, S" uniqKey="Drapier S" first="S" last="Drapier">S. Drapier</name></author><author><name sortKey="Haegelen, C" sort="Haegelen, C" uniqKey="Haegelen C" first="C" last="Haegelen">C. Haegelen</name></author><author><name sortKey="Drapier, D" sort="Drapier, D" uniqKey="Drapier D" first="D" last="Drapier">D. Drapier</name></author><author><name sortKey="Millet, B" sort="Millet, B" uniqKey="Millet B" first="B" last="Millet">B. Millet</name></author><author><name sortKey="Garin, E" sort="Garin, E" uniqKey="Garin E" first="E" last="Garin">E. Garin</name></author><author><name sortKey="Herry, J Y" sort="Herry, J Y" uniqKey="Herry J" first="J-Y" last="Herry">J-Y Herry</name></author><author><name sortKey="Malbert, C H" sort="Malbert, C H" uniqKey="Malbert C" first="C-H" last="Malbert">C-H Malbert</name></author><author><name sortKey="Verin, M" sort="Verin, M" uniqKey="Verin M" first="M" last="Vérin">M. Vérin</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18490359</idno><idno type="pmid">18490359</idno><idno type="doi">10.1093/brain/awn084</idno><idno type="wicri:Area/PubMed/Corpus">000C88</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C88</idno><idno type="wicri:Area/PubMed/Curation">000C48</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000C48</idno><idno type="wicri:Area/PubMed/Checkpoint">000C48</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000C48</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Subthalamic nucleus stimulation affects orbitofrontal cortex in facial emotion recognition: a PET study.</title><author><name sortKey="Le Jeune, F" sort="Le Jeune, F" uniqKey="Le Jeune F" first="F" last="Le Jeune">F. Le Jeune</name><affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Nucléaire, Centre Eugène Marquis, rue de la Bataille Flandres Dunkerque, 35042 Rennes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Médecine Nucléaire, Centre Eugène Marquis, rue de la Bataille Flandres Dunkerque, 35042 Rennes</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Peron, J" sort="Peron, J" uniqKey="Peron J" first="J" last="Péron">J. Péron</name></author><author><name sortKey="Biseul, I" sort="Biseul, I" uniqKey="Biseul I" first="I" last="Biseul">I. Biseul</name></author><author><name sortKey="Fournier, S" sort="Fournier, S" uniqKey="Fournier S" first="S" last="Fournier">S. Fournier</name></author><author><name sortKey="Sauleau, P" sort="Sauleau, P" uniqKey="Sauleau P" first="P" last="Sauleau">P. Sauleau</name></author><author><name sortKey="Drapier, S" sort="Drapier, S" uniqKey="Drapier S" first="S" last="Drapier">S. Drapier</name></author><author><name sortKey="Haegelen, C" sort="Haegelen, C" uniqKey="Haegelen C" first="C" last="Haegelen">C. Haegelen</name></author><author><name sortKey="Drapier, D" sort="Drapier, D" uniqKey="Drapier D" first="D" last="Drapier">D. Drapier</name></author><author><name sortKey="Millet, B" sort="Millet, B" uniqKey="Millet B" first="B" last="Millet">B. Millet</name></author><author><name sortKey="Garin, E" sort="Garin, E" uniqKey="Garin E" first="E" last="Garin">E. Garin</name></author><author><name sortKey="Herry, J Y" sort="Herry, J Y" uniqKey="Herry J" first="J-Y" last="Herry">J-Y Herry</name></author><author><name sortKey="Malbert, C H" sort="Malbert, C H" uniqKey="Malbert C" first="C-H" last="Malbert">C-H Malbert</name></author><author><name sortKey="Verin, M" sort="Verin, M" uniqKey="Verin M" first="M" last="Vérin">M. Vérin</name></author></analytic><series><title level="j">Brain : a journal of neurology</title><idno type="eISSN">1460-2156</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Case-Control Studies</term><term>Deep Brain Stimulation (adverse effects)</term><term>Deep Brain Stimulation (methods)</term><term>Facial Expression</term><term>Fear</term><term>Female</term><term>Fluorodeoxyglucose F18</term><term>Frontal Lobe (diagnostic imaging)</term><term>Frontal Lobe (physiology)</term><term>Glucose (metabolism)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (psychology)</term><term>Parkinson Disease (therapy)</term><term>Positron-Emission Tomography</term><term>Recognition (Psychology)</term><term>Statistics, Nonparametric</term><term>Subthalamic Nucleus (diagnostic imaging)</term><term>Subthalamic Nucleus (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glucose</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Fluorodeoxyglucose F18</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Frontal Lobe</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Frontal Lobe</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term><term>Facial Expression</term><term>Fear</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Positron-Emission Tomography</term><term>Recognition (Psychology)</term><term>Statistics, Nonparametric</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation (DBS) of the bilateral subthalamic nucleus (STN) in Parkinson's disease is thought to produce adverse events such as emotional disorders, and in a recent study, we found fear recognition to be impaired as a result. These changes have been attributed to disturbance of the STN's limbic territory and would appear to confirm that the negative emotion recognition network passes through the STN. In addition, it is now widely acknowledged that damage to the orbitofrontal cortex (OFC), especially the right side, can result in impaired recognition of facial emotions (RFE). In this context, we hypothesized that this reduced recognition of fear is correlated with modifications in the cerebral glucose metabolism of the right OFC. The objective of the present study was first, to reinforce our previous results by demonstrating reduced fear recognition in our Parkinson's disease patient group following STN DBS and, second, to correlate these emotional performances with glucose metabolism using (18)FDG-PET. The (18)FDG-PET and RFE tasks were both performed by a cohort of 13 Parkinson's disease patients 3 months before and 3 months after surgery for STN DBS. As predicted, we observed a significant reduction in fear recognition following surgery and obtained a positive correlation between these neuropsychological results and changes in glucose metabolism, especially in the right OFC. These results confirm the role of the STN as a key basal ganglia structure in limbic circuits.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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