Bilateral subthalamic nucleus stimulation in advanced Parkinson's disease: three years follow-up.
Identifieur interne : 000728 ( Ncbi/Merge ); précédent : 000727; suivant : 000729Bilateral subthalamic nucleus stimulation in advanced Parkinson's disease: three years follow-up.
Auteurs : Jing Gan [France] ; Jing Xie-Brustolin ; Patrick Mertens ; Gustavo Polo ; Hélène Klinger ; Hélène Mollion ; Isabelle Benatru ; Emmanuel Henry ; Emmanuel Broussolle ; Stéphane ThoboisSource :
- Journal of neurology [ 0340-5354 ] ; 2007.
English descriptors
- KwdEn :
- Adult, Aged, Antiparkinson Agents (therapeutic use), Deep Brain Stimulation (methods), Female, Follow-Up Studies, Functional Laterality, Geriatric Assessment, Humans, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (drug therapy), Parkinson Disease (pathology), Parkinson Disease (surgery), Severity of Illness Index, Stereotaxic Techniques, Subthalamic Nucleus (surgery).
- MESH :
- chemical , therapeutic use : Antiparkinson Agents.
- drug therapy : Parkinson Disease.
- methods : Deep Brain Stimulation.
- pathology : Parkinson Disease.
- surgery : Parkinson Disease, Subthalamic Nucleus.
- Adult, Aged, Female, Follow-Up Studies, Functional Laterality, Geriatric Assessment, Humans, Male, Middle Aged, Neuropsychological Tests, Severity of Illness Index, Stereotaxic Techniques.
Abstract
To assess the long-term efficacy and safety of chronic bilateral stimulation of the subthalamic nucleus (STN) in patients with advanced Parkinson's disease (PD).
DOI: 10.1007/s00415-006-0297-6
PubMed: 17508144
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- to stream PubMed, to step Corpus: 000E15
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pubmed:17508144Le document en format XML
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<author><name sortKey="Xie Brustolin, Jing" sort="Xie Brustolin, Jing" uniqKey="Xie Brustolin J" first="Jing" last="Xie-Brustolin">Jing Xie-Brustolin</name>
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<author><name sortKey="Klinger, Helene" sort="Klinger, Helene" uniqKey="Klinger H" first="Hélène" last="Klinger">Hélène Klinger</name>
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<author><name sortKey="Mollion, Helene" sort="Mollion, Helene" uniqKey="Mollion H" first="Hélène" last="Mollion">Hélène Mollion</name>
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<author><name sortKey="Benatru, Isabelle" sort="Benatru, Isabelle" uniqKey="Benatru I" first="Isabelle" last="Benatru">Isabelle Benatru</name>
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<author><name sortKey="Henry, Emmanuel" sort="Henry, Emmanuel" uniqKey="Henry E" first="Emmanuel" last="Henry">Emmanuel Henry</name>
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<author><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name>
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<author><name sortKey="Mollion, Helene" sort="Mollion, Helene" uniqKey="Mollion H" first="Hélène" last="Mollion">Hélène Mollion</name>
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<author><name sortKey="Henry, Emmanuel" sort="Henry, Emmanuel" uniqKey="Henry E" first="Emmanuel" last="Henry">Emmanuel Henry</name>
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<term>Deep Brain Stimulation (methods)</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Functional Laterality</term>
<term>Geriatric Assessment</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (surgery)</term>
<term>Severity of Illness Index</term>
<term>Stereotaxic Techniques</term>
<term>Subthalamic Nucleus (surgery)</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term>
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<term>Subthalamic Nucleus</term>
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<term>Aged</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Functional Laterality</term>
<term>Geriatric Assessment</term>
<term>Humans</term>
<term>Male</term>
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<front><div type="abstract" xml:lang="en">To assess the long-term efficacy and safety of chronic bilateral stimulation of the subthalamic nucleus (STN) in patients with advanced Parkinson's disease (PD).</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17508144</PMID>
<DateCreated><Year>2007</Year>
<Month>05</Month>
<Day>17</Day>
</DateCreated>
<DateCompleted><Year>2007</Year>
<Month>07</Month>
<Day>10</Day>
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<Month>05</Month>
<Day>17</Day>
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<JournalIssue CitedMedium="Print"><Volume>254</Volume>
<Issue>1</Issue>
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<Month>Jan</Month>
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<Title>Journal of neurology</Title>
<ISOAbbreviation>J. Neurol.</ISOAbbreviation>
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<ArticleTitle>Bilateral subthalamic nucleus stimulation in advanced Parkinson's disease: three years follow-up.</ArticleTitle>
<Pagination><MedlinePgn>99-106</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To assess the long-term efficacy and safety of chronic bilateral stimulation of the subthalamic nucleus (STN) in patients with advanced Parkinson's disease (PD).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">36 consecutive patients with idiopathic Parkinson's disease treated with bilateral stimulation of the STN were studied. Parkinsonian status was assessed preoperatively and at 1 and 3 years postoperatively using the Unified Parkinson's Disease Rating Scale (UPDRS) and neuropsychological evaluation in on and off-medication / on and off stimulation conditions.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">At 3 years follow-up, STN stimulation reduced the UPDRS motor score by 54.2 % compared to baseline in the off-medication conditions. Tremor, rigidity, bradykinesia, postural stability, and gait improved by 72.2 %, 62.4 %, 56.8 %, 40.5 % and 45.3 %, respectively. UPDRS part II scores were reduced by 41.4 %. The overall dopaminergic drugs dose was reduced by 48.6 % after surgery and four patients were no longer taking antiparkinsonian medication at three years. However, axial dopa-unresponsive signs worsened in some patients. The most frequent transient adverse event consisted in mood disorders in 23 patients.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our data demonstrate that: 1) bilateral STN stimulation is relatively safe, improves the motor symptoms and drug-related motor complications of PD, and reduces the daily dosage of medication; 2) this benefit is sustained over time despite the occurrence of axial doparesistant signs in some patients.</AbstractText>
</Abstract>
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