An effect of dopamine depletion on decision-making: the temporal coupling of deliberation and execution.
Identifieur interne : 000576 ( Ncbi/Merge ); précédent : 000575; suivant : 000577An effect of dopamine depletion on decision-making: the temporal coupling of deliberation and execution.
Auteurs : Mathias Pessiglione [France] ; Virginie Czernecki ; Bernard Pillon ; Bruno Dubois ; Michael Schüpbach ; Yves Agid [France] ; Léon TremblaySource :
- Journal of cognitive neuroscience [ 0898-929X ] ; 2005.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (adverse effects), Antiparkinson Agents (therapeutic use), Basal Ganglia (drug effects), Basal Ganglia (physiology), Data Interpretation, Statistical, Decision Making (physiology), Dihydroxyphenylalanine (metabolism), Dopamine (deficiency), Dopamine (physiology), Dopamine Agents (adverse effects), Dopamine Agents (therapeutic use), Electrodes, Implanted, Female, Humans, Male, Middle Aged, Parkinson Disease (physiopathology), Psychomotor Performance (physiology), Reaction Time (physiology).
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Dopamine Agents.
- chemical , deficiency : Dopamine.
- chemical , metabolism : Dihydroxyphenylalanine.
- chemical , physiology : Dopamine.
- chemical , therapeutic use : Antiparkinson Agents, Dopamine Agents.
- drug effects : Basal Ganglia.
- physiology : Basal Ganglia, Decision Making, Psychomotor Performance, Reaction Time.
- physiopathology : Parkinson Disease.
- Aged, Data Interpretation, Statistical, Electrodes, Implanted, Female, Humans, Male, Middle Aged.
Abstract
When a decision between alternative actions has to be made, the primate brain is able to uncouple motor execution from mental deliberation, providing time for higher cognitive processes such as remembering and reasoning. The mental deliberation leading to the decision and the motor execution applying the decision are likely to involve different neuronal circuits linking the basal ganglia and the frontal cortex. Behavioral and physiological studies in monkeys indicate that dopamine depletion may result in a loss of functional segregation between these circuits, hence, in interference between the deliberation and execution processes. To test this hypothesis in humans, we analyzed the movements of parkinsonian patients in a go/no-go task, contrasting periods of uncertainty with periods of knowledge about the rule to be applied. Two groups of patients were compared to healthy subjects: one group was treated with dopaminergic medication and the other with deep brain stimulation; both groups were also tested without any treatment. In healthy subjects, the movement time was unaffected by uncertainty. In untreated patients, the movement time increased with uncertainty, reflecting interference between deliberation and execution processes. This interference was fully corrected with dopaminergic medication but was unchanged with deep brain stimulation. Moreover, decision-related hesitations were detectable in the movements of dopamine-depleted patients, revealing a temporal coupling of deliberation and execution. We suggest that such coupling may be related to the loss of dopamine-mediated functional segregation between basal ganglia circuits processing different stages of goal-directed behavior.
DOI: 10.1162/089892905775008661
PubMed: 16356326
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sort="Pessiglione, Mathias" uniqKey="Pessiglione M" first="Mathias" last="Pessiglione">Mathias Pessiglione</name><affiliation wicri:level="3"><nlm:affiliation>Hôpital de la Salpêtrière, Paris, France. pessigli@ccr.jussieu.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital de la Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Czernecki, Virginie" sort="Czernecki, Virginie" uniqKey="Czernecki V" first="Virginie" last="Czernecki">Virginie Czernecki</name></author><author><name sortKey="Pillon, Bernard" sort="Pillon, Bernard" uniqKey="Pillon B" first="Bernard" last="Pillon">Bernard Pillon</name></author><author><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name></author><author><name sortKey="Schupbach, 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The mental deliberation leading to the decision and the motor execution applying the decision are likely to involve different neuronal circuits linking the basal ganglia and the frontal cortex. Behavioral and physiological studies in monkeys indicate that dopamine depletion may result in a loss of functional segregation between these circuits, hence, in interference between the deliberation and execution processes. To test this hypothesis in humans, we analyzed the movements of parkinsonian patients in a go/no-go task, contrasting periods of uncertainty with periods of knowledge about the rule to be applied. Two groups of patients were compared to healthy subjects: one group was treated with dopaminergic medication and the other with deep brain stimulation; both groups were also tested without any treatment. In healthy subjects, the movement time was unaffected by uncertainty. In untreated patients, the movement time increased with uncertainty, reflecting interference between deliberation and execution processes. This interference was fully corrected with dopaminergic medication but was unchanged with deep brain stimulation. Moreover, decision-related hesitations were detectable in the movements of dopamine-depleted patients, revealing a temporal coupling of deliberation and execution. We suggest that such coupling may be related to the loss of dopamine-mediated functional segregation between basal ganglia circuits processing different stages of goal-directed behavior.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16356326</PMID><DateCreated><Year>2005</Year><Month>12</Month><Day>16</Day></DateCreated><DateCompleted><Year>2006</Year><Month>03</Month><Day>15</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0898-929X</ISSN><JournalIssue CitedMedium="Print"><Volume>17</Volume><Issue>12</Issue><PubDate><Year>2005</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Journal of cognitive neuroscience</Title><ISOAbbreviation>J Cogn Neurosci</ISOAbbreviation></Journal><ArticleTitle>An effect of dopamine depletion on decision-making: the temporal coupling of deliberation and execution.</ArticleTitle><Pagination><MedlinePgn>1886-96</MedlinePgn></Pagination><Abstract><AbstractText>When a decision between alternative actions has to be made, the primate brain is able to uncouple motor execution from mental deliberation, providing time for higher cognitive processes such as remembering and reasoning. The mental deliberation leading to the decision and the motor execution applying the decision are likely to involve different neuronal circuits linking the basal ganglia and the frontal cortex. Behavioral and physiological studies in monkeys indicate that dopamine depletion may result in a loss of functional segregation between these circuits, hence, in interference between the deliberation and execution processes. To test this hypothesis in humans, we analyzed the movements of parkinsonian patients in a go/no-go task, contrasting periods of uncertainty with periods of knowledge about the rule to be applied. Two groups of patients were compared to healthy subjects: one group was treated with dopaminergic medication and the other with deep brain stimulation; both groups were also tested without any treatment. In healthy subjects, the movement time was unaffected by uncertainty. In untreated patients, the movement time increased with uncertainty, reflecting interference between deliberation and execution processes. This interference was fully corrected with dopaminergic medication but was unchanged with deep brain stimulation. Moreover, decision-related hesitations were detectable in the movements of dopamine-depleted patients, revealing a temporal coupling of deliberation and execution. We suggest that such coupling may be related to the loss of dopamine-mediated functional segregation between basal ganglia circuits processing different stages of goal-directed behavior.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pessiglione</LastName><ForeName>Mathias</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Hôpital de la Salpêtrière, Paris, France. pessigli@ccr.jussieu.fr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Czernecki</LastName><ForeName>Virginie</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Pillon</LastName><ForeName>Bernard</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Dubois</LastName><ForeName>Bruno</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Schüpbach</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Agid</LastName><ForeName>Yves</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Tremblay</LastName><ForeName>Léon</ForeName><Initials>L</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Cogn Neurosci</MedlineTA><NlmUniqueID>8910747</NlmUniqueID><ISSNLinking>0898-929X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015259">Dopamine Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>63-84-3</RegistryNumber><NameOfSubstance 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Implanted</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011597" MajorTopicYN="N">Psychomotor Performance</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011930" MajorTopicYN="N">Reaction Time</DescriptorName><QualifierName UI="Q000502" 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uniqKey="Czernecki V" first="Virginie" last="Czernecki">Virginie Czernecki</name><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name><name sortKey="Pillon, Bernard" sort="Pillon, Bernard" uniqKey="Pillon B" first="Bernard" last="Pillon">Bernard Pillon</name><name sortKey="Schupbach, Michael" sort="Schupbach, Michael" uniqKey="Schupbach M" first="Michael" last="Schüpbach">Michael Schüpbach</name><name sortKey="Tremblay, Leon" sort="Tremblay, Leon" uniqKey="Tremblay L" first="Léon" last="Tremblay">Léon Tremblay</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Pessiglione, Mathias" sort="Pessiglione, Mathias" uniqKey="Pessiglione M" first="Mathias" last="Pessiglione">Mathias Pessiglione</name></region><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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