Executive processes in Parkinson's disease: FDG-PET and network analysis.
Identifieur interne : 000451 ( Ncbi/Merge ); précédent : 000450; suivant : 000452Executive processes in Parkinson's disease: FDG-PET and network analysis.
Auteurs : Catherine Lozza [France] ; Jean-Claude Baron ; David Eidelberg ; Marc J. Mentis ; Maren Carbon ; Rose-Marie MariéSource :
- Human brain mapping [ 1065-9471 ] ; 2004.
English descriptors
- KwdEn :
- Adult, Aged, Brain (diagnostic imaging), Brain (metabolism), Brain (physiopathology), Corpus Striatum (diagnostic imaging), Corpus Striatum (metabolism), Corpus Striatum (physiopathology), Female, Fluorodeoxyglucose F18, Frontal Lobe (diagnostic imaging), Frontal Lobe (metabolism), Frontal Lobe (physiopathology), Humans, Male, Middle Aged, Movement (physiology), Nerve Net (diagnostic imaging), Nerve Net (metabolism), Nerve Net (physiopathology), Neural Networks (Computer), Neural Pathways (diagnostic imaging), Neural Pathways (metabolism), Neural Pathways (physiopathology), Parkinson Disease (diagnostic imaging), Parkinson Disease (metabolism), Parkinson Disease (physiopathology), Tomography, Emission-Computed.
- MESH :
- chemical : Fluorodeoxyglucose F18.
- diagnostic imaging : Brain, Corpus Striatum, Frontal Lobe, Nerve Net, Neural Pathways, Parkinson Disease.
- metabolism : Brain, Corpus Striatum, Frontal Lobe, Nerve Net, Neural Pathways, Parkinson Disease.
- physiology : Movement.
- physiopathology : Brain, Corpus Striatum, Frontal Lobe, Nerve Net, Neural Pathways, Parkinson Disease.
- Adult, Aged, Female, Humans, Male, Middle Aged, Neural Networks (Computer), Tomography, Emission-Computed.
Abstract
It is assumed widely that the clinical expression of Parkinson's Disease (PD), both motor and cognitive, is subtended by topographically distributed brain networks. However, little is known about the functional neuroanatomy of executive dysfunction in PD. Our objective was to validate further in a PD group the use of network analysis to assess the relationship between executive processes and pathological disorganization of frontostriatal networks. We studied 15 patients with idiopathic PD, and 7 age-matched normal controls, using resting [(18)F]fluorodeoxyglucose (FDG) and high-resolution positron emission tomography (PET). We carried out network analysis on regional metabolic data to identify specific covariation patterns associated with motor and executive dysfunction. We detected two independent patterns relating respectively to the two clinical abnormalities. The first pattern (principal component 1) was topographically similar to that described previously in other PD populations. Subject scores for this pattern discriminated patients from controls and correlated significantly with bradykinesia ratings (P = 0.013, r = 0.655) in PD patients. The second pattern (principal component 2) was characterized by relative ventromedial frontal, hippocampal, and striatal hypometabolism, associated with mediodorsal thalamic hypermetabolism. In the PD group, scores from this pattern correlated with scores on the conditional associative learning (CAL; P = 0.01, r = 0.690) and the Brown Peterson paradigm (BPP; P = 0.017, r = -0.651) tests, respectively assessing strategy and planning, and working memory. According to these findings, the networks subserving bradykinesia and executive dysfunction in PD seems to be topographically distinct and to involve different aspects of subcortico-cortical processing.
DOI: 10.1002/hbm.20033
PubMed: 15195290
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001008
- to stream PubMed, to step Curation: 000F67
- to stream PubMed, to step Checkpoint: 000F67
Links to Exploration step
pubmed:15195290Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Executive processes in Parkinson's disease: FDG-PET and network analysis.</title>
<author><name sortKey="Lozza, Catherine" sort="Lozza, Catherine" uniqKey="Lozza C" first="Catherine" last="Lozza">Catherine Lozza</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM U 320, Centre Cyceron, Caen, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U 320, Centre Cyceron, Caen</wicri:regionArea>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Baron, Jean Claude" sort="Baron, Jean Claude" uniqKey="Baron J" first="Jean-Claude" last="Baron">Jean-Claude Baron</name>
</author>
<author><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name>
</author>
<author><name sortKey="Mentis, Marc J" sort="Mentis, Marc J" uniqKey="Mentis M" first="Marc J" last="Mentis">Marc J. Mentis</name>
</author>
<author><name sortKey="Carbon, Maren" sort="Carbon, Maren" uniqKey="Carbon M" first="Maren" last="Carbon">Maren Carbon</name>
</author>
<author><name sortKey="Marie, Rose Marie" sort="Marie, Rose Marie" uniqKey="Marie R" first="Rose-Marie" last="Marié">Rose-Marie Marié</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2004">2004</date>
<idno type="RBID">pubmed:15195290</idno>
<idno type="pmid">15195290</idno>
<idno type="doi">10.1002/hbm.20033</idno>
<idno type="wicri:Area/PubMed/Corpus">001008</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001008</idno>
<idno type="wicri:Area/PubMed/Curation">000F67</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000F67</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000F67</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000F67</idno>
<idno type="wicri:Area/Ncbi/Merge">000451</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Executive processes in Parkinson's disease: FDG-PET and network analysis.</title>
<author><name sortKey="Lozza, Catherine" sort="Lozza, Catherine" uniqKey="Lozza C" first="Catherine" last="Lozza">Catherine Lozza</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM U 320, Centre Cyceron, Caen, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U 320, Centre Cyceron, Caen</wicri:regionArea>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Baron, Jean Claude" sort="Baron, Jean Claude" uniqKey="Baron J" first="Jean-Claude" last="Baron">Jean-Claude Baron</name>
</author>
<author><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name>
</author>
<author><name sortKey="Mentis, Marc J" sort="Mentis, Marc J" uniqKey="Mentis M" first="Marc J" last="Mentis">Marc J. Mentis</name>
</author>
<author><name sortKey="Carbon, Maren" sort="Carbon, Maren" uniqKey="Carbon M" first="Maren" last="Carbon">Maren Carbon</name>
</author>
<author><name sortKey="Marie, Rose Marie" sort="Marie, Rose Marie" uniqKey="Marie R" first="Rose-Marie" last="Marié">Rose-Marie Marié</name>
</author>
</analytic>
<series><title level="j">Human brain mapping</title>
<idno type="ISSN">1065-9471</idno>
<imprint><date when="2004" type="published">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Brain (diagnostic imaging)</term>
<term>Brain (metabolism)</term>
<term>Brain (physiopathology)</term>
<term>Corpus Striatum (diagnostic imaging)</term>
<term>Corpus Striatum (metabolism)</term>
<term>Corpus Striatum (physiopathology)</term>
<term>Female</term>
<term>Fluorodeoxyglucose F18</term>
<term>Frontal Lobe (diagnostic imaging)</term>
<term>Frontal Lobe (metabolism)</term>
<term>Frontal Lobe (physiopathology)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Movement (physiology)</term>
<term>Nerve Net (diagnostic imaging)</term>
<term>Nerve Net (metabolism)</term>
<term>Nerve Net (physiopathology)</term>
<term>Neural Networks (Computer)</term>
<term>Neural Pathways (diagnostic imaging)</term>
<term>Neural Pathways (metabolism)</term>
<term>Neural Pathways (physiopathology)</term>
<term>Parkinson Disease (diagnostic imaging)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Tomography, Emission-Computed</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Fluorodeoxyglucose F18</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Brain</term>
<term>Corpus Striatum</term>
<term>Frontal Lobe</term>
<term>Nerve Net</term>
<term>Neural Pathways</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term>
<term>Corpus Striatum</term>
<term>Frontal Lobe</term>
<term>Nerve Net</term>
<term>Neural Pathways</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Movement</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term>
<term>Corpus Striatum</term>
<term>Frontal Lobe</term>
<term>Nerve Net</term>
<term>Neural Pathways</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neural Networks (Computer)</term>
<term>Tomography, Emission-Computed</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">It is assumed widely that the clinical expression of Parkinson's Disease (PD), both motor and cognitive, is subtended by topographically distributed brain networks. However, little is known about the functional neuroanatomy of executive dysfunction in PD. Our objective was to validate further in a PD group the use of network analysis to assess the relationship between executive processes and pathological disorganization of frontostriatal networks. We studied 15 patients with idiopathic PD, and 7 age-matched normal controls, using resting [(18)F]fluorodeoxyglucose (FDG) and high-resolution positron emission tomography (PET). We carried out network analysis on regional metabolic data to identify specific covariation patterns associated with motor and executive dysfunction. We detected two independent patterns relating respectively to the two clinical abnormalities. The first pattern (principal component 1) was topographically similar to that described previously in other PD populations. Subject scores for this pattern discriminated patients from controls and correlated significantly with bradykinesia ratings (P = 0.013, r = 0.655) in PD patients. The second pattern (principal component 2) was characterized by relative ventromedial frontal, hippocampal, and striatal hypometabolism, associated with mediodorsal thalamic hypermetabolism. In the PD group, scores from this pattern correlated with scores on the conditional associative learning (CAL; P = 0.01, r = 0.690) and the Brown Peterson paradigm (BPP; P = 0.017, r = -0.651) tests, respectively assessing strategy and planning, and working memory. According to these findings, the networks subserving bradykinesia and executive dysfunction in PD seems to be topographically distinct and to involve different aspects of subcortico-cortical processing.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15195290</PMID>
<DateCreated><Year>2004</Year>
<Month>06</Month>
<Day>14</Day>
</DateCreated>
<DateCompleted><Year>2004</Year>
<Month>09</Month>
<Day>08</Day>
</DateCompleted>
<DateRevised><Year>2016</Year>
<Month>11</Month>
<Day>24</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">1065-9471</ISSN>
<JournalIssue CitedMedium="Print"><Volume>22</Volume>
<Issue>3</Issue>
<PubDate><Year>2004</Year>
<Month>Jul</Month>
</PubDate>
</JournalIssue>
<Title>Human brain mapping</Title>
<ISOAbbreviation>Hum Brain Mapp</ISOAbbreviation>
</Journal>
<ArticleTitle>Executive processes in Parkinson's disease: FDG-PET and network analysis.</ArticleTitle>
<Pagination><MedlinePgn>236-45</MedlinePgn>
</Pagination>
<Abstract><AbstractText>It is assumed widely that the clinical expression of Parkinson's Disease (PD), both motor and cognitive, is subtended by topographically distributed brain networks. However, little is known about the functional neuroanatomy of executive dysfunction in PD. Our objective was to validate further in a PD group the use of network analysis to assess the relationship between executive processes and pathological disorganization of frontostriatal networks. We studied 15 patients with idiopathic PD, and 7 age-matched normal controls, using resting [(18)F]fluorodeoxyglucose (FDG) and high-resolution positron emission tomography (PET). We carried out network analysis on regional metabolic data to identify specific covariation patterns associated with motor and executive dysfunction. We detected two independent patterns relating respectively to the two clinical abnormalities. The first pattern (principal component 1) was topographically similar to that described previously in other PD populations. Subject scores for this pattern discriminated patients from controls and correlated significantly with bradykinesia ratings (P = 0.013, r = 0.655) in PD patients. The second pattern (principal component 2) was characterized by relative ventromedial frontal, hippocampal, and striatal hypometabolism, associated with mediodorsal thalamic hypermetabolism. In the PD group, scores from this pattern correlated with scores on the conditional associative learning (CAL; P = 0.01, r = 0.690) and the Brown Peterson paradigm (BPP; P = 0.017, r = -0.651) tests, respectively assessing strategy and planning, and working memory. According to these findings, the networks subserving bradykinesia and executive dysfunction in PD seems to be topographically distinct and to involve different aspects of subcortico-cortical processing.</AbstractText>
<CopyrightInformation>Copyright 2004 Wiley-Liss, Inc.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lozza</LastName>
<ForeName>Catherine</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>INSERM U 320, Centre Cyceron, Caen, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Baron</LastName>
<ForeName>Jean-Claude</ForeName>
<Initials>JC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Eidelberg</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
</Author>
<Author ValidYN="Y"><LastName>Mentis</LastName>
<ForeName>Marc J</ForeName>
<Initials>MJ</Initials>
</Author>
<Author ValidYN="Y"><LastName>Carbon</LastName>
<ForeName>Maren</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Marié</LastName>
<ForeName>Rose-Marie</ForeName>
<Initials>RM</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Hum Brain Mapp</MedlineTA>
<NlmUniqueID>9419065</NlmUniqueID>
<ISSNLinking>1065-9471</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0Z5B2CJX4D</RegistryNumber>
<NameOfSubstance UI="D019788">Fluorodeoxyglucose F18</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003342" MajorTopicYN="N">Corpus Striatum</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019788" MajorTopicYN="N">Fluorodeoxyglucose F18</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005625" MajorTopicYN="N">Frontal Lobe</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009068" MajorTopicYN="N">Movement</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009415" MajorTopicYN="N">Nerve Net</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016571" MajorTopicYN="N">Neural Networks (Computer)</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009434" MajorTopicYN="N">Neural Pathways</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014055" MajorTopicYN="N">Tomography, Emission-Computed</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2004</Year>
<Month>6</Month>
<Day>15</Day>
<Hour>5</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2004</Year>
<Month>9</Month>
<Day>9</Day>
<Hour>5</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2004</Year>
<Month>6</Month>
<Day>15</Day>
<Hour>5</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">15195290</ArticleId>
<ArticleId IdType="doi">10.1002/hbm.20033</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>France</li>
</country>
<region><li>Basse-Normandie</li>
<li>Région Normandie</li>
</region>
<settlement><li>Caen</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Baron, Jean Claude" sort="Baron, Jean Claude" uniqKey="Baron J" first="Jean-Claude" last="Baron">Jean-Claude Baron</name>
<name sortKey="Carbon, Maren" sort="Carbon, Maren" uniqKey="Carbon M" first="Maren" last="Carbon">Maren Carbon</name>
<name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name>
<name sortKey="Marie, Rose Marie" sort="Marie, Rose Marie" uniqKey="Marie R" first="Rose-Marie" last="Marié">Rose-Marie Marié</name>
<name sortKey="Mentis, Marc J" sort="Mentis, Marc J" uniqKey="Mentis M" first="Marc J" last="Mentis">Marc J. Mentis</name>
</noCountry>
<country name="France"><region name="Région Normandie"><name sortKey="Lozza, Catherine" sort="Lozza, Catherine" uniqKey="Lozza C" first="Catherine" last="Lozza">Catherine Lozza</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000451 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000451 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Ncbi |étape= Merge |type= RBID |clé= pubmed:15195290 |texte= Executive processes in Parkinson's disease: FDG-PET and network analysis. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:15195290" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
![]() | This area was generated with Dilib version V0.6.29. | ![]() |