Manganese, monoamine metabolite levels at birth, and child psychomotor development.
Identifieur interne : 000357 ( Ncbi/Merge ); précédent : 000356; suivant : 000358Manganese, monoamine metabolite levels at birth, and child psychomotor development.
Auteurs : Larissa Takser [France] ; Donna Mergler ; Georgette Hellier ; Josiane Sahuquillo ; Guy HuelSource :
- Neurotoxicology [ 0161-813X ] ; 2003.
English descriptors
- KwdEn :
- Adult, Biogenic Monoamines (blood), Chi-Square Distribution, Child, Child, Preschool, Female, Fetal Blood (drug effects), Fetal Blood (metabolism), Follow-Up Studies, Humans, Infant, Infant, Newborn, Male, Manganese (blood), Manganese (pharmacology), Neuropsychological Tests (statistics & numerical data), Pregnancy, Prenatal Exposure Delayed Effects, Prospective Studies, Psychomotor Disorders (blood), Psychomotor Disorders (chemically induced), Psychomotor Performance (physiology), Regression Analysis, Statistics, Nonparametric.
- MESH :
- chemical , blood : Biogenic Monoamines, Manganese.
- blood : Psychomotor Disorders.
- chemically induced : Psychomotor Disorders.
- drug effects : Fetal Blood.
- metabolism : Fetal Blood.
- chemical , pharmacology : Manganese.
- physiology : Psychomotor Performance.
- statistics & numerical data : Neuropsychological Tests.
- Adult, Chi-Square Distribution, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Male, Pregnancy, Prenatal Exposure Delayed Effects, Prospective Studies, Regression Analysis, Statistics, Nonparametric.
Abstract
Several studies have demonstrated neurobehavioral impairment related to manganese (Mn) exposure in the workplace. Exposure to high doses of manganese is associated with irreversible neurodegenerative disorders resembling idiopathic Parkinson disease. Although there is a risk of Mn accumulation in the foetus during pregnancy, little information exists about developmental effects of environmental low-level exposure in human. For this reason, we conducted a prospective epidemiological study in 247 healthy pregnant women and their babies to determine the long-term effect of in utero Mn levels on child's psychomotor development. Concurrently, we examined the relationship between Mn tissue levels at delivery and foetal plasma monoamine metabolites. Of the newborns, 195 were examined at 9 months, 126 at 3 years and 100 at 6 years. At 9 months, the Brunet-Lézine scales were administered. The McCarthy scales of children's abilities were used at 3 and 6 years. After adjustment for potential confounding co-factors (child's gender, mother's educational level), negative relationships were observed between cord blood Mn levels and several psychomotor sub-scales at age of 3 years: "attention" (partial r=-0.33, P<0.001), "non-verbal memory" (partial r=-0.28, P<0.01), and "hand skills" (partial r=-0.22, P<0.05). No significant relationships were observed between Mn measures at birth and the general psychomotor indices, Brunet-Lézine developmental quotient (DQ) at 9 months or McCarthy general cognitive index (GCI) at 3 and 6 years. Maternal blood Mn levels were negatively associated with foetal plasma HVA and 5-HIAA concentrations (adjusted for labour duration, child's gender, and smoking during pregnancy), but the adjustment for monoamine levels at birth did not change the association between the Mn levels and the psychomotor scores. These results suggest that environmental Mn exposure in utero could affect early psychomotor development.
DOI: 10.1016/S0161-813X(03)00058-5
PubMed: 12900080
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pubmed:12900080Le document en format XML
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Paul-Vaillant Couturier, 94807 Villejuif</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Villejuif</settlement></placeName></affiliation></author><author><name sortKey="Mergler, Donna" sort="Mergler, Donna" uniqKey="Mergler D" first="Donna" last="Mergler">Donna Mergler</name></author><author><name sortKey="Hellier, Georgette" sort="Hellier, Georgette" uniqKey="Hellier G" first="Georgette" last="Hellier">Georgette Hellier</name></author><author><name sortKey="Sahuquillo, Josiane" sort="Sahuquillo, Josiane" uniqKey="Sahuquillo J" first="Josiane" last="Sahuquillo">Josiane Sahuquillo</name></author><author><name sortKey="Huel, Guy" sort="Huel, Guy" uniqKey="Huel G" first="Guy" last="Huel">Guy Huel</name></author></analytic><series><title level="j">Neurotoxicology</title><idno type="ISSN">0161-813X</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Biogenic Monoamines (blood)</term><term>Chi-Square Distribution</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Fetal Blood (drug effects)</term><term>Fetal Blood (metabolism)</term><term>Follow-Up Studies</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Male</term><term>Manganese (blood)</term><term>Manganese (pharmacology)</term><term>Neuropsychological Tests (statistics & numerical data)</term><term>Pregnancy</term><term>Prenatal Exposure Delayed Effects</term><term>Prospective Studies</term><term>Psychomotor Disorders (blood)</term><term>Psychomotor Disorders (chemically induced)</term><term>Psychomotor Performance (physiology)</term><term>Regression Analysis</term><term>Statistics, Nonparametric</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biogenic Monoamines</term><term>Manganese</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Psychomotor Disorders</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Psychomotor Disorders</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Fetal Blood</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Fetal Blood</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Manganese</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Neuropsychological Tests</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Chi-Square Distribution</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Male</term><term>Pregnancy</term><term>Prenatal Exposure Delayed Effects</term><term>Prospective Studies</term><term>Regression Analysis</term><term>Statistics, Nonparametric</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several studies have demonstrated neurobehavioral impairment related to manganese (Mn) exposure in the workplace. Exposure to high doses of manganese is associated with irreversible neurodegenerative disorders resembling idiopathic Parkinson disease. Although there is a risk of Mn accumulation in the foetus during pregnancy, little information exists about developmental effects of environmental low-level exposure in human. For this reason, we conducted a prospective epidemiological study in 247 healthy pregnant women and their babies to determine the long-term effect of in utero Mn levels on child's psychomotor development. Concurrently, we examined the relationship between Mn tissue levels at delivery and foetal plasma monoamine metabolites. Of the newborns, 195 were examined at 9 months, 126 at 3 years and 100 at 6 years. At 9 months, the Brunet-Lézine scales were administered. The McCarthy scales of children's abilities were used at 3 and 6 years. After adjustment for potential confounding co-factors (child's gender, mother's educational level), negative relationships were observed between cord blood Mn levels and several psychomotor sub-scales at age of 3 years: "attention" (partial r=-0.33, P<0.001), "non-verbal memory" (partial r=-0.28, P<0.01), and "hand skills" (partial r=-0.22, P<0.05). No significant relationships were observed between Mn measures at birth and the general psychomotor indices, Brunet-Lézine developmental quotient (DQ) at 9 months or McCarthy general cognitive index (GCI) at 3 and 6 years. Maternal blood Mn levels were negatively associated with foetal plasma HVA and 5-HIAA concentrations (adjusted for labour duration, child's gender, and smoking during pregnancy), but the adjustment for monoamine levels at birth did not change the association between the Mn levels and the psychomotor scores. These results suggest that environmental Mn exposure in utero could affect early psychomotor development.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12900080</PMID><DateCreated><Year>2003</Year><Month>08</Month><Day>05</Day></DateCreated><DateCompleted><Year>2003</Year><Month>10</Month><Day>27</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0161-813X</ISSN><JournalIssue CitedMedium="Print"><Volume>24</Volume><Issue>4-5</Issue><PubDate><Year>2003</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Neurotoxicology</Title><ISOAbbreviation>Neurotoxicology</ISOAbbreviation></Journal><ArticleTitle>Manganese, monoamine metabolite levels at birth, and child psychomotor development.</ArticleTitle><Pagination><MedlinePgn>667-74</MedlinePgn></Pagination><Abstract><AbstractText>Several studies have demonstrated neurobehavioral impairment related to manganese (Mn) exposure in the workplace. Exposure to high doses of manganese is associated with irreversible neurodegenerative disorders resembling idiopathic Parkinson disease. Although there is a risk of Mn accumulation in the foetus during pregnancy, little information exists about developmental effects of environmental low-level exposure in human. For this reason, we conducted a prospective epidemiological study in 247 healthy pregnant women and their babies to determine the long-term effect of in utero Mn levels on child's psychomotor development. Concurrently, we examined the relationship between Mn tissue levels at delivery and foetal plasma monoamine metabolites. Of the newborns, 195 were examined at 9 months, 126 at 3 years and 100 at 6 years. At 9 months, the Brunet-Lézine scales were administered. The McCarthy scales of children's abilities were used at 3 and 6 years. After adjustment for potential confounding co-factors (child's gender, mother's educational level), negative relationships were observed between cord blood Mn levels and several psychomotor sub-scales at age of 3 years: "attention" (partial r=-0.33, P<0.001), "non-verbal memory" (partial r=-0.28, P<0.01), and "hand skills" (partial r=-0.22, P<0.05). No significant relationships were observed between Mn measures at birth and the general psychomotor indices, Brunet-Lézine developmental quotient (DQ) at 9 months or McCarthy general cognitive index (GCI) at 3 and 6 years. Maternal blood Mn levels were negatively associated with foetal plasma HVA and 5-HIAA concentrations (adjusted for labour duration, child's gender, and smoking during pregnancy), but the adjustment for monoamine levels at birth did not change the association between the Mn levels and the psychomotor scores. These results suggest that environmental Mn exposure in utero could affect early psychomotor development.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Takser</LastName><ForeName>Larissa</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institut National de la Santé et de la Recherche Médicale (INSERM-U472), Recherche en Epidemiologie et en Biostatistique, 16 Avenue Paul-Vaillant Couturier, 94807 Villejuif, France. takser@vjf.inserm.fr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mergler</LastName><ForeName>Donna</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Hellier</LastName><ForeName>Georgette</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Sahuquillo</LastName><ForeName>Josiane</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Huel</LastName><ForeName>Guy</ForeName><Initials>G</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Neurotoxicology</MedlineTA><NlmUniqueID>7905589</NlmUniqueID><ISSNLinking>0161-813X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015306">Biogenic Monoamines</NameOfSubstance></Chemical><Chemical><RegistryNumber>42Z2K6ZL8P</RegistryNumber><NameOfSubstance UI="D008345">Manganese</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015306" MajorTopicYN="N">Biogenic Monoamines</DescriptorName><QualifierName UI="Q000097" 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Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011596" MajorTopicYN="N">Psychomotor Disorders</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011597" MajorTopicYN="N">Psychomotor Performance</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012044" MajorTopicYN="N">Regression Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018709" MajorTopicYN="N">Statistics, Nonparametric</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>8</Month><Day>6</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2003</Year><Month>10</Month><Day>28</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2003</Year><Month>8</Month><Day>6</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12900080</ArticleId><ArticleId IdType="pii">S0161-813X(03)00058-5</ArticleId><ArticleId IdType="doi">10.1016/S0161-813X(03)00058-5</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Villejuif</li></settlement></list><tree><noCountry><name sortKey="Hellier, Georgette" sort="Hellier, Georgette" uniqKey="Hellier G" first="Georgette" last="Hellier">Georgette Hellier</name><name sortKey="Huel, Guy" sort="Huel, Guy" uniqKey="Huel G" first="Guy" last="Huel">Guy Huel</name><name sortKey="Mergler, Donna" sort="Mergler, Donna" uniqKey="Mergler D" first="Donna" last="Mergler">Donna Mergler</name><name sortKey="Sahuquillo, Josiane" sort="Sahuquillo, Josiane" uniqKey="Sahuquillo J" first="Josiane" last="Sahuquillo">Josiane Sahuquillo</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Takser, Larissa" sort="Takser, Larissa" uniqKey="Takser L" first="Larissa" last="Takser">Larissa Takser</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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