Nicotine protects rat brain mitochondria against experimental injuries.
Identifieur interne : 000318 ( Ncbi/Merge ); précédent : 000317; suivant : 000319Nicotine protects rat brain mitochondria against experimental injuries.
Auteurs : A. Cormier [France] ; C. Morin ; R. Zini ; J-P Tillement ; G. LagrueSource :
- Neuropharmacology [ 0028-3908 ] ; 2003.
English descriptors
- KwdEn :
- Animals, Brain (drug effects), Brain (metabolism), Cell Hypoxia (drug effects), Cell Hypoxia (physiology), Dose-Response Relationship, Drug, Male, Mitochondria (drug effects), Mitochondria (metabolism), Nicotine (administration & dosage), Oxygen Consumption (drug effects), Oxygen Consumption (physiology), Rats, Rats, Wistar.
- MESH :
- chemical , administration & dosage : Nicotine.
- drug effects : Brain, Cell Hypoxia, Mitochondria, Oxygen Consumption.
- metabolism : Brain, Mitochondria.
- physiology : Cell Hypoxia, Oxygen Consumption.
- Animals, Dose-Response Relationship, Drug, Male, Rats, Rats, Wistar.
Abstract
Epidemiological studies have reported that cigarette smoking may protect from neurodegenerative diseases such as Parkinson's disease. These protective effects are thought to be mediated by nicotine. Recent data showed that nicotine significantly decreases respiratory control ratio (RCR) and superoxide anion generation of brain mitochondria. Thus, we investigated nicotine effects on rat brain in two experimental models: first, an in vitro anoxia/reoxygenation experiment and secondly, an in vivo rotenone-induced Parkinson-like syndrome. Anoxia/reoxygenation impaired mitochondrial respiration by 43.68% whereas in the presence of nicotine, it was less impaired, by 31.1% at 10(-7) M. In rats chronically administered rotenone (3 mg/kg/day), we observed profound mitochondrial damage: the RCR decreased by 50.36% and the superoxide anion generation and the membrane anisotropy increased by 56.03 and 13.43%, respectively. All of these indications of mitochondrial damage were limited by chronic administration of nicotine. Nicotine developed mitochondrial effects in vivo and in vitro at very low concentration. All these results were in accordance with epidemiological studies, which report a protective effect of nicotine in neurodegenerative diseases. Thus, we propose that one effect of nicotine is to preserve mitochondrial functions of the rat central nervous system.
PubMed: 12668050
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001113
- to stream PubMed, to step Curation: 001072
- to stream PubMed, to step Checkpoint: 001072
Links to Exploration step
pubmed:12668050Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nicotine protects rat brain mitochondria against experimental injuries.</title><author><name sortKey="Cormier, A" sort="Cormier, A" uniqKey="Cormier A" first="A" last="Cormier">A. Cormier</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de Pharmacologie, Department de Pharmacologie, Faculté de Médecine de Paris XII, 8 rue de General Sarrail, F94010 Creteil, France. a.cormier@univ-paris12.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Pharmacologie, Department de Pharmacologie, Faculté de Médecine de Paris XII, 8 rue de General Sarrail, F94010 Creteil</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Creteil</settlement></placeName></affiliation></author><author><name sortKey="Morin, C" sort="Morin, C" uniqKey="Morin C" first="C" last="Morin">C. Morin</name></author><author><name sortKey="Zini, R" sort="Zini, R" uniqKey="Zini R" first="R" last="Zini">R. Zini</name></author><author><name sortKey="Tillement, J P" sort="Tillement, J P" uniqKey="Tillement J" first="J-P" last="Tillement">J-P Tillement</name></author><author><name sortKey="Lagrue, G" sort="Lagrue, G" uniqKey="Lagrue G" first="G" last="Lagrue">G. Lagrue</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:12668050</idno><idno type="pmid">12668050</idno><idno type="wicri:Area/PubMed/Corpus">001113</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001113</idno><idno type="wicri:Area/PubMed/Curation">001072</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001072</idno><idno type="wicri:Area/PubMed/Checkpoint">001072</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001072</idno><idno type="wicri:Area/Ncbi/Merge">000318</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Nicotine protects rat brain mitochondria against experimental injuries.</title><author><name sortKey="Cormier, A" sort="Cormier, A" uniqKey="Cormier A" first="A" last="Cormier">A. Cormier</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de Pharmacologie, Department de Pharmacologie, Faculté de Médecine de Paris XII, 8 rue de General Sarrail, F94010 Creteil, France. a.cormier@univ-paris12.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Pharmacologie, Department de Pharmacologie, Faculté de Médecine de Paris XII, 8 rue de General Sarrail, F94010 Creteil</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Creteil</settlement></placeName></affiliation></author><author><name sortKey="Morin, C" sort="Morin, C" uniqKey="Morin C" first="C" last="Morin">C. Morin</name></author><author><name sortKey="Zini, R" sort="Zini, R" uniqKey="Zini R" first="R" last="Zini">R. Zini</name></author><author><name sortKey="Tillement, J P" sort="Tillement, J P" uniqKey="Tillement J" first="J-P" last="Tillement">J-P Tillement</name></author><author><name sortKey="Lagrue, G" sort="Lagrue, G" uniqKey="Lagrue G" first="G" last="Lagrue">G. Lagrue</name></author></analytic><series><title level="j">Neuropharmacology</title><idno type="ISSN">0028-3908</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Brain (drug effects)</term><term>Brain (metabolism)</term><term>Cell Hypoxia (drug effects)</term><term>Cell Hypoxia (physiology)</term><term>Dose-Response Relationship, Drug</term><term>Male</term><term>Mitochondria (drug effects)</term><term>Mitochondria (metabolism)</term><term>Nicotine (administration & dosage)</term><term>Oxygen Consumption (drug effects)</term><term>Oxygen Consumption (physiology)</term><term>Rats</term><term>Rats, Wistar</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Nicotine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Brain</term><term>Cell Hypoxia</term><term>Mitochondria</term><term>Oxygen Consumption</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term><term>Mitochondria</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cell Hypoxia</term><term>Oxygen Consumption</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dose-Response Relationship, Drug</term><term>Male</term><term>Rats</term><term>Rats, Wistar</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Epidemiological studies have reported that cigarette smoking may protect from neurodegenerative diseases such as Parkinson's disease. These protective effects are thought to be mediated by nicotine. Recent data showed that nicotine significantly decreases respiratory control ratio (RCR) and superoxide anion generation of brain mitochondria. Thus, we investigated nicotine effects on rat brain in two experimental models: first, an in vitro anoxia/reoxygenation experiment and secondly, an in vivo rotenone-induced Parkinson-like syndrome. Anoxia/reoxygenation impaired mitochondrial respiration by 43.68% whereas in the presence of nicotine, it was less impaired, by 31.1% at 10(-7) M. In rats chronically administered rotenone (3 mg/kg/day), we observed profound mitochondrial damage: the RCR decreased by 50.36% and the superoxide anion generation and the membrane anisotropy increased by 56.03 and 13.43%, respectively. All of these indications of mitochondrial damage were limited by chronic administration of nicotine. Nicotine developed mitochondrial effects in vivo and in vitro at very low concentration. All these results were in accordance with epidemiological studies, which report a protective effect of nicotine in neurodegenerative diseases. Thus, we propose that one effect of nicotine is to preserve mitochondrial functions of the rat central nervous system.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12668050</PMID><DateCreated><Year>2003</Year><Month>04</Month><Day>01</Day></DateCreated><DateCompleted><Year>2003</Year><Month>06</Month><Day>23</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0028-3908</ISSN><JournalIssue CitedMedium="Print"><Volume>44</Volume><Issue>5</Issue><PubDate><Year>2003</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Neuropharmacology</Title><ISOAbbreviation>Neuropharmacology</ISOAbbreviation></Journal><ArticleTitle>Nicotine protects rat brain mitochondria against experimental injuries.</ArticleTitle><Pagination><MedlinePgn>642-52</MedlinePgn></Pagination><Abstract><AbstractText>Epidemiological studies have reported that cigarette smoking may protect from neurodegenerative diseases such as Parkinson's disease. These protective effects are thought to be mediated by nicotine. Recent data showed that nicotine significantly decreases respiratory control ratio (RCR) and superoxide anion generation of brain mitochondria. Thus, we investigated nicotine effects on rat brain in two experimental models: first, an in vitro anoxia/reoxygenation experiment and secondly, an in vivo rotenone-induced Parkinson-like syndrome. Anoxia/reoxygenation impaired mitochondrial respiration by 43.68% whereas in the presence of nicotine, it was less impaired, by 31.1% at 10(-7) M. In rats chronically administered rotenone (3 mg/kg/day), we observed profound mitochondrial damage: the RCR decreased by 50.36% and the superoxide anion generation and the membrane anisotropy increased by 56.03 and 13.43%, respectively. All of these indications of mitochondrial damage were limited by chronic administration of nicotine. Nicotine developed mitochondrial effects in vivo and in vitro at very low concentration. All these results were in accordance with epidemiological studies, which report a protective effect of nicotine in neurodegenerative diseases. Thus, we propose that one effect of nicotine is to preserve mitochondrial functions of the rat central nervous system.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cormier</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Laboratoire de Pharmacologie, Department de Pharmacologie, Faculté de Médecine de Paris XII, 8 rue de General Sarrail, F94010 Creteil, France. a.cormier@univ-paris12.fr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morin</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Zini</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Tillement</LastName><ForeName>J-P</ForeName><Initials>JP</Initials></Author><Author ValidYN="Y"><LastName>Lagrue</LastName><ForeName>G</ForeName><Initials>G</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Neuropharmacology</MedlineTA><NlmUniqueID>0236217</NlmUniqueID><ISSNLinking>0028-3908</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>6M3C89ZY6R</RegistryNumber><NameOfSubstance UI="D009538">Nicotine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015687" MajorTopicYN="N">Cell Hypoxia</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008928" MajorTopicYN="N">Mitochondria</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009538" MajorTopicYN="N">Nicotine</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010101" MajorTopicYN="N">Oxygen Consumption</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017208" MajorTopicYN="N">Rats, Wistar</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>4</Month><Day>2</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2003</Year><Month>6</Month><Day>24</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2003</Year><Month>4</Month><Day>2</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12668050</ArticleId><ArticleId IdType="pii">S0028390803000418</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Creteil</li></settlement></list><tree><noCountry><name sortKey="Lagrue, G" sort="Lagrue, G" uniqKey="Lagrue G" first="G" last="Lagrue">G. Lagrue</name><name sortKey="Morin, C" sort="Morin, C" uniqKey="Morin C" first="C" last="Morin">C. Morin</name><name sortKey="Tillement, J P" sort="Tillement, J P" uniqKey="Tillement J" first="J-P" last="Tillement">J-P Tillement</name><name sortKey="Zini, R" sort="Zini, R" uniqKey="Zini R" first="R" last="Zini">R. Zini</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Cormier, A" sort="Cormier, A" uniqKey="Cormier A" first="A" last="Cormier">A. Cormier</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000318 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000318 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= pubmed:12668050
|texte= Nicotine protects rat brain mitochondria against experimental injuries.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:12668050" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |