The impact on Parkinson's disease of electrical parameter settings in STN stimulation.
Identifieur interne : 000276 ( Ncbi/Merge ); précédent : 000275; suivant : 000277The impact on Parkinson's disease of electrical parameter settings in STN stimulation.
Auteurs : E. Moro [France] ; R J A. Esselink ; J. Xie ; M. Hommel ; A L Benabid ; P. PollakSource :
- Neurology [ 0028-3878 ] ; 2002.
English descriptors
- KwdEn :
- MESH :
- methods : Electric Stimulation Therapy.
- standards : Electric Stimulation Therapy.
- therapy : Parkinson Disease, Tremor.
- Adult, Calibration, Double-Blind Method, Humans, Middle Aged, Movement.
Abstract
The main advantage of deep brain stimulation (DBS) in the treatment of PD is that the electrical settings can be adjusted to optimize benefits and minimize adverse effects. The main objective of this study was to discover how varying these electrical parameters impacted on parkinsonian motor signs.
PubMed: 12221161
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The impact on Parkinson's disease of electrical parameter settings in STN stimulation.</title><author><name sortKey="Moro, E" sort="Moro, E" uniqKey="Moro E" first="E" last="Moro">E. Moro</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical and Biological Neurosciences and INSERM U318, Joseph Fourier University, CHU de Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical and Biological Neurosciences and INSERM U318, Joseph Fourier University, CHU de Grenoble</wicri:regionArea><wicri:noRegion>CHU de Grenoble</wicri:noRegion><wicri:noRegion>CHU de Grenoble</wicri:noRegion></affiliation></author><author><name sortKey="Esselink, R J A" sort="Esselink, R J A" uniqKey="Esselink R" first="R J A" last="Esselink">R J A. Esselink</name></author><author><name sortKey="Xie, J" sort="Xie, J" uniqKey="Xie J" first="J" last="Xie">J. Xie</name></author><author><name sortKey="Hommel, M" sort="Hommel, M" uniqKey="Hommel M" first="M" last="Hommel">M. Hommel</name></author><author><name sortKey="Benabid, A L" sort="Benabid, A L" uniqKey="Benabid A" first="A L" last="Benabid">A L Benabid</name></author><author><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P" last="Pollak">P. Pollak</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2002">2002</date><idno type="RBID">pubmed:12221161</idno><idno type="pmid">12221161</idno><idno type="wicri:Area/PubMed/Corpus">001168</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001168</idno><idno type="wicri:Area/PubMed/Curation">001127</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001127</idno><idno type="wicri:Area/PubMed/Checkpoint">001127</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001127</idno><idno type="wicri:Area/Ncbi/Merge">000276</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The impact on Parkinson's disease of electrical parameter settings in STN stimulation.</title><author><name sortKey="Moro, E" sort="Moro, E" uniqKey="Moro E" first="E" last="Moro">E. Moro</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical and Biological Neurosciences and INSERM U318, Joseph Fourier University, CHU de Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical and Biological Neurosciences and INSERM U318, Joseph Fourier University, CHU de Grenoble</wicri:regionArea><wicri:noRegion>CHU de Grenoble</wicri:noRegion><wicri:noRegion>CHU de Grenoble</wicri:noRegion></affiliation></author><author><name sortKey="Esselink, R J A" sort="Esselink, R J A" uniqKey="Esselink R" first="R J A" last="Esselink">R J A. Esselink</name></author><author><name sortKey="Xie, J" sort="Xie, J" uniqKey="Xie J" first="J" last="Xie">J. Xie</name></author><author><name sortKey="Hommel, M" sort="Hommel, M" uniqKey="Hommel M" first="M" last="Hommel">M. Hommel</name></author><author><name sortKey="Benabid, A L" sort="Benabid, A L" uniqKey="Benabid A" first="A L" last="Benabid">A L Benabid</name></author><author><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P" last="Pollak">P. Pollak</name></author></analytic><series><title level="j">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2002" type="published">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Calibration</term><term>Double-Blind Method</term><term>Electric Stimulation Therapy (methods)</term><term>Electric Stimulation Therapy (standards)</term><term>Humans</term><term>Middle Aged</term><term>Movement</term><term>Parkinson Disease (therapy)</term><term>Tremor (therapy)</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electric Stimulation Therapy</term></keywords><keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Electric Stimulation Therapy</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term><term>Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Calibration</term><term>Double-Blind Method</term><term>Humans</term><term>Middle Aged</term><term>Movement</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The main advantage of deep brain stimulation (DBS) in the treatment of PD is that the electrical settings can be adjusted to optimize benefits and minimize adverse effects. The main objective of this study was to discover how varying these electrical parameters impacted on parkinsonian motor signs.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12221161</PMID><DateCreated><Year>2002</Year><Month>09</Month><Day>10</Day></DateCreated><DateCompleted><Year>2002</Year><Month>10</Month><Day>04</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0028-3878</ISSN><JournalIssue CitedMedium="Print"><Volume>59</Volume><Issue>5</Issue><PubDate><Year>2002</Year><Month>Sep</Month><Day>10</Day></PubDate></JournalIssue><Title>Neurology</Title><ISOAbbreviation>Neurology</ISOAbbreviation></Journal><ArticleTitle>The impact on Parkinson's disease of electrical parameter settings in STN stimulation.</ArticleTitle><Pagination><MedlinePgn>706-13</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The main advantage of deep brain stimulation (DBS) in the treatment of PD is that the electrical settings can be adjusted to optimize benefits and minimize adverse effects. The main objective of this study was to discover how varying these electrical parameters impacted on parkinsonian motor signs.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Twelve patients with PD with chronic bilateral subthalamic nucleus (STN) stimulation were selected. The authors evaluated the effects of a variation in the voltages, frequencies, and pulse widths on tremor, bradykinesia, and rigidity using two different paradigms: one in which the total electrical energy delivered was held constant, and one in which this was varied. Up to 26 parameter conditions were tested under double blind randomized conditions.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Voltages >or=3 V and frequencies >or=130 Hz led to the greatest improvement in all three parkinsonian signs. A rate of 5 Hz significantly worsened akinesia. The combination of the highest voltage with the narrowest pulse width was most effective.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This study confirms that the most beneficial effects induced by STN stimulation are obtained at high frequencies and that voltage is the most critical factor to obtain adequate alteration in STN activity. The mechanisms by which STN DBS improves parkinsonism remain speculative.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Moro</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Clinical and Biological Neurosciences and INSERM U318, Joseph Fourier University, CHU de Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Esselink</LastName><ForeName>R J A</ForeName><Initials>RJ</Initials></Author><Author ValidYN="Y"><LastName>Xie</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Hommel</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Benabid</LastName><ForeName>A L</ForeName><Initials>AL</Initials></Author><Author ValidYN="Y"><LastName>Pollak</LastName><ForeName>P</ForeName><Initials>P</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neurology</MedlineTA><NlmUniqueID>0401060</NlmUniqueID><ISSNLinking>0028-3878</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002138" MajorTopicYN="N">Calibration</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004599" MajorTopicYN="N">Electric Stimulation Therapy</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName><QualifierName UI="Q000592" MajorTopicYN="N">standards</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009068" MajorTopicYN="N">Movement</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014202" MajorTopicYN="N">Tremor</DescriptorName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2002</Year><Month>9</Month><Day>11</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2002</Year><Month>10</Month><Day>9</Day><Hour>4</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2002</Year><Month>9</Month><Day>11</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12221161</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Benabid, A L" sort="Benabid, A L" uniqKey="Benabid A" first="A L" last="Benabid">A L Benabid</name><name sortKey="Esselink, R J A" sort="Esselink, R J A" uniqKey="Esselink R" first="R J A" last="Esselink">R J A. Esselink</name><name sortKey="Hommel, M" sort="Hommel, M" uniqKey="Hommel M" first="M" last="Hommel">M. Hommel</name><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P" last="Pollak">P. Pollak</name><name sortKey="Xie, J" sort="Xie, J" uniqKey="Xie J" first="J" last="Xie">J. Xie</name></noCountry><country name="France"><noRegion><name sortKey="Moro, E" sort="Moro, E" uniqKey="Moro E" first="E" last="Moro">E. Moro</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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