Improvement of memory guided saccades in parkinsonian patients by high frequency subthalamic nucleus stimulation
Identifieur interne : 000087 ( Ncbi/Merge ); précédent : 000086; suivant : 000088Improvement of memory guided saccades in parkinsonian patients by high frequency subthalamic nucleus stimulation
Auteurs : S. Rivaud-Pechoux ; A. Vermersch ; B. Gaymard ; C. Ploner ; B. Bejjani ; P. Damier ; S. Demeret ; Yves Agid [France] ; C. Pierrot-Deseillig.Source :
- Journal of Neurology, Neurosurgery, and Psychiatry [ 0022-3050 ] ; 2000.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Levodopa.
- physiology : Memory, Reaction Time, Saccades.
- physiopathology : Parkinson Disease, Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Electric Stimulation Therapy, Humans, Middle Aged.
Abstract
Recent studies in the monkey suggest that the subthalamic nucleus (STN) is involved in control of eye movement, yet its functional significance in humans is unknown. Saccadic eye movements were studied in eight parkinsonian patients treated by bilateral electrical stimulation of the STN. STN stimulation improved the accuracy of memory guided saccades but not of reflexive visually guided saccades and had no effect on the antisaccade task. This study shows that, by contrast with levodopa, STN stimulation improves memory guided saccade deficits, and illustrates for the first time in humans the role of the STN in the control of purposive saccades.
Url:
DOI: 10.1136/jnnp.68.3.381
PubMed: 10675227
PubMed Central: 1736813
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PMC:1736813Le document en format XML
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high frequency subthalamic nucleus stimulation</title><author><name sortKey="Rivaud Pechoux, S" sort="Rivaud Pechoux, S" uniqKey="Rivaud Pechoux S" first="S." last="Rivaud-Pechoux">S. Rivaud-Pechoux</name></author><author><name sortKey="Vermersch, A" sort="Vermersch, A" uniqKey="Vermersch A" first="A." last="Vermersch">A. Vermersch</name></author><author><name sortKey="Gaymard, B" sort="Gaymard, B" uniqKey="Gaymard B" first="B." last="Gaymard">B. Gaymard</name></author><author><name sortKey="Ploner, C" sort="Ploner, C" uniqKey="Ploner C" first="C." last="Ploner">C. Ploner</name></author><author><name sortKey="Bejjani, B" sort="Bejjani, B" uniqKey="Bejjani B" first="B." last="Bejjani">B. Bejjani</name></author><author><name sortKey="Damier, P" sort="Damier, P" uniqKey="Damier P" first="P." last="Damier">P. Damier</name></author><author><name sortKey="Demeret, S" sort="Demeret, S" uniqKey="Demeret S" first="S." last="Demeret">S. Demeret</name></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author><author><name sortKey="Pierrot Deseillig, C" sort="Pierrot Deseillig, C" uniqKey="Pierrot Deseillig C" first="C." last="Pierrot-Deseillig.">C. Pierrot-Deseillig.</name></author></analytic><series><title level="j">Journal of Neurology, Neurosurgery, and Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><date when="2000">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Electric Stimulation Therapy</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Memory (physiology)</term><term>Middle Aged</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Reaction Time (physiology)</term><term>Saccades (physiology)</term><term>Subthalamic Nucleus (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Memory</term><term>Reaction Time</term><term>Saccades</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Electric Stimulation Therapy</term><term>Humans</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Recent studies in the monkey suggest that the subthalamic
nucleus (STN) is involved in control of eye movement, yet its
functional significance in humans is unknown. Saccadic eye movements
were studied in eight parkinsonian patients treated by bilateral
electrical stimulation of the STN. STN stimulation improved the
accuracy of memory guided saccades but not of reflexive visually guided saccades and had no effect on the antisaccade task. This study shows
that, by contrast with levodopa, STN stimulation improves memory guided
saccade deficits, and illustrates for the first time in humans the role
of the STN in the control of purposive saccades.
</p></div></front></TEI><double pmid="10675227"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Improvement of memory guided saccades in parkinsonian patients by
high frequency subthalamic nucleus stimulation</title><author><name sortKey="Rivaud Pechoux, S" sort="Rivaud Pechoux, S" uniqKey="Rivaud Pechoux S" first="S." last="Rivaud-Pechoux">S. Rivaud-Pechoux</name></author><author><name sortKey="Vermersch, A" sort="Vermersch, A" uniqKey="Vermersch A" first="A." last="Vermersch">A. Vermersch</name></author><author><name sortKey="Gaymard, B" sort="Gaymard, B" uniqKey="Gaymard B" first="B." last="Gaymard">B. Gaymard</name></author><author><name sortKey="Ploner, C" sort="Ploner, C" uniqKey="Ploner C" first="C." last="Ploner">C. Ploner</name></author><author><name sortKey="Bejjani, B" sort="Bejjani, B" uniqKey="Bejjani B" first="B." last="Bejjani">B. Bejjani</name></author><author><name sortKey="Damier, P" sort="Damier, P" uniqKey="Damier P" first="P." last="Damier">P. Damier</name></author><author><name sortKey="Demeret, S" sort="Demeret, S" uniqKey="Demeret S" first="S." last="Demeret">S. Demeret</name></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author><author><name sortKey="Pierrot Deseillig, C" sort="Pierrot Deseillig, C" uniqKey="Pierrot Deseillig C" first="C." last="Pierrot-Deseillig.">C. Pierrot-Deseillig.</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">10675227</idno><idno type="pmc">1736813</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1736813</idno><idno type="RBID">PMC:1736813</idno><idno type="doi">10.1136/jnnp.68.3.381</idno><date when="2000">2000</date><idno type="wicri:Area/Pmc/Corpus">000330</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000330</idno><idno type="wicri:Area/Pmc/Curation">000328</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000328</idno><idno type="wicri:Area/Pmc/Checkpoint">000938</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000938</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Improvement of memory guided saccades in parkinsonian patients by
high frequency subthalamic nucleus stimulation</title><author><name sortKey="Rivaud Pechoux, S" sort="Rivaud Pechoux, S" uniqKey="Rivaud Pechoux S" first="S." last="Rivaud-Pechoux">S. Rivaud-Pechoux</name></author><author><name sortKey="Vermersch, A" sort="Vermersch, A" uniqKey="Vermersch A" first="A." last="Vermersch">A. Vermersch</name></author><author><name sortKey="Gaymard, B" sort="Gaymard, B" uniqKey="Gaymard B" first="B." last="Gaymard">B. Gaymard</name></author><author><name sortKey="Ploner, C" sort="Ploner, C" uniqKey="Ploner C" first="C." last="Ploner">C. Ploner</name></author><author><name sortKey="Bejjani, B" sort="Bejjani, B" uniqKey="Bejjani B" first="B." last="Bejjani">B. Bejjani</name></author><author><name sortKey="Damier, P" sort="Damier, P" uniqKey="Damier P" first="P." last="Damier">P. Damier</name></author><author><name sortKey="Demeret, S" sort="Demeret, S" uniqKey="Demeret S" first="S." last="Demeret">S. Demeret</name></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author><author><name sortKey="Pierrot Deseillig, C" sort="Pierrot Deseillig, C" uniqKey="Pierrot Deseillig C" first="C." last="Pierrot-Deseillig.">C. Pierrot-Deseillig.</name></author></analytic><series><title level="j">Journal of Neurology, Neurosurgery, and Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><date when="2000">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Recent studies in the monkey suggest that the subthalamic
nucleus (STN) is involved in control of eye movement, yet its
functional significance in humans is unknown. Saccadic eye movements
were studied in eight parkinsonian patients treated by bilateral
electrical stimulation of the STN. STN stimulation improved the
accuracy of memory guided saccades but not of reflexive visually guided saccades and had no effect on the antisaccade task. This study shows
that, by contrast with levodopa, STN stimulation improves memory guided
saccade deficits, and illustrates for the first time in humans the role
of the STN in the control of purposive saccades.
</p></div></front></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Improvement of memory guided saccades in parkinsonian patients by high frequency subthalamic nucleus stimulation.</title><author><name sortKey="Rivaud Pechoux, S" sort="Rivaud Pechoux, S" uniqKey="Rivaud Pechoux S" first="S" last="Rivaud-Péchoux">S. Rivaud-Péchoux</name><affiliation wicri:level="3"><nlm:affiliation>INSERM U289, Hôpital de la Salpêtrière, 47 bd de l'Hôpital, 75651 Paris Cedex 13, France. rivaud@ccr.jussieu.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U289, Hôpital de la Salpêtrière, 47 bd de l'Hôpital, 75651 Paris Cedex 13</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Vermersch, A I" sort="Vermersch, A I" uniqKey="Vermersch A" first="A I" last="Vermersch">A I Vermersch</name></author><author><name sortKey="Gaymard, B" sort="Gaymard, B" uniqKey="Gaymard B" first="B" last="Gaymard">B. Gaymard</name></author><author><name sortKey="Ploner, C J" sort="Ploner, C J" uniqKey="Ploner C" first="C J" last="Ploner">C J Ploner</name></author><author><name sortKey="Bejjani, B P" sort="Bejjani, B P" uniqKey="Bejjani B" first="B P" last="Bejjani">B P Bejjani</name></author><author><name sortKey="Damier, P" sort="Damier, P" uniqKey="Damier P" first="P" last="Damier">P. Damier</name></author><author><name sortKey="Demeret, S" sort="Demeret, S" uniqKey="Demeret S" first="S" last="Demeret">S. Demeret</name></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author><author><name sortKey="Pierrot Deseilligny, C" sort="Pierrot Deseilligny, C" uniqKey="Pierrot Deseilligny C" first="C" last="Pierrot-Deseilligny">C. Pierrot-Deseilligny</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2000">2000</date><idno type="RBID">pubmed:10675227</idno><idno type="pmid">10675227</idno><idno type="wicri:Area/PubMed/Corpus">001342</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001342</idno><idno type="wicri:Area/PubMed/Curation">001301</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001301</idno><idno type="wicri:Area/PubMed/Checkpoint">001301</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001301</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Improvement of memory guided saccades in parkinsonian patients by high frequency subthalamic nucleus stimulation.</title><author><name sortKey="Rivaud Pechoux, S" sort="Rivaud Pechoux, S" uniqKey="Rivaud Pechoux S" first="S" last="Rivaud-Péchoux">S. Rivaud-Péchoux</name><affiliation wicri:level="3"><nlm:affiliation>INSERM U289, Hôpital de la Salpêtrière, 47 bd de l'Hôpital, 75651 Paris Cedex 13, France. rivaud@ccr.jussieu.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U289, Hôpital de la Salpêtrière, 47 bd de l'Hôpital, 75651 Paris Cedex 13</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Vermersch, A I" sort="Vermersch, A I" uniqKey="Vermersch A" first="A I" last="Vermersch">A I Vermersch</name></author><author><name sortKey="Gaymard, B" sort="Gaymard, B" uniqKey="Gaymard B" first="B" last="Gaymard">B. Gaymard</name></author><author><name sortKey="Ploner, C J" sort="Ploner, C J" uniqKey="Ploner C" first="C J" last="Ploner">C J Ploner</name></author><author><name sortKey="Bejjani, B P" sort="Bejjani, B P" uniqKey="Bejjani B" first="B P" last="Bejjani">B P Bejjani</name></author><author><name sortKey="Damier, P" sort="Damier, P" uniqKey="Damier P" first="P" last="Damier">P. Damier</name></author><author><name sortKey="Demeret, S" sort="Demeret, S" uniqKey="Demeret S" first="S" last="Demeret">S. Demeret</name></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author><author><name sortKey="Pierrot Deseilligny, C" sort="Pierrot Deseilligny, C" uniqKey="Pierrot Deseilligny C" first="C" last="Pierrot-Deseilligny">C. Pierrot-Deseilligny</name></author></analytic><series><title level="j">Journal of neurology, neurosurgery, and psychiatry</title><idno type="ISSN">0022-3050</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Electric Stimulation Therapy</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Memory (physiology)</term><term>Middle Aged</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Reaction Time (physiology)</term><term>Saccades (physiology)</term><term>Subthalamic Nucleus (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Memory</term><term>Reaction Time</term><term>Saccades</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Electric Stimulation Therapy</term><term>Humans</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent studies in the monkey suggest that the subthalamic nucleus (STN) is involved in control of eye movement, yet its functional significance in humans is unknown. Saccadic eye movements were studied in eight parkinsonian patients treated by bilateral electrical stimulation of the STN. STN stimulation improved the accuracy of memory guided saccades but not of reflexive visually guided saccades and had no effect on the antisaccade task. This study shows that, by contrast with levodopa, STN stimulation improves memory guided saccade deficits, and illustrates for the first time in humans the role of the STN in the control of purposive saccades.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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