ParkinsonFranceV1, Ncbi, Merge, bibRecord, 000008

Multicentre European study of thalamic stimulation in parkinsonian and essential tremor

Identifieur interne : 000008 ( Ncbi/Merge ); précédent : 000007; suivant : 000009

Multicentre European study of thalamic stimulation in parkinsonian and essential tremor

Auteurs : P. Limousin ; J. Speelman ; F. Gielen ; M. Janssens ; C. Study

Source :

Journal of Neurology, Neurosurgery, and Psychiatry [ 0022-3050 ] ; 1999.

RBID : PMC:1736277

English descriptors

KwdEn :
- Activities of Daily Living, Aged, Electric Stimulation Therapy, Female, Follow-Up Studies, Functional Laterality, Humans, Male, Middle Aged, Parkinson Disease (physiopathology), Thalamic Nuclei (physiopathology).
MESH :
- physiopathology : Parkinson Disease, Thalamic Nuclei.
- Activities of Daily Living, Aged, Electric Stimulation Therapy, Female, Follow-Up Studies, Functional Laterality, Humans, Male, Middle Aged.

Abstract

OBJECTIVES—Thalamic stimulation has been proposed to treat disabling tremor. The aims of this multicentre study were to evaluate the efficacy and the morbidity of thalamic stimulation in a large number of patients with parkinsonian or essential tremor. METHODS—One hundred and eleven patients were included in the study and 110 were implanted either unilaterally or bilaterally. Patients were evaluated with clinical scales, before and up to 12 months after surgery. RESULTS—Upper and lower limb tremor scores were reduced in both groups. Eighty five per cent of the electrodes satisfied the arbitrary criteria of two point reduction in rest tremor reduction in the parkinsonian tremor group and 89% for postural tremor reduction in the essential tremor group. In the parkinsonian tremor group, limb akinesia and limb rigidity scores were moderately but significantly reduced. Axial scores were unchanged. In the essential tremor group, head tremor was significantly reduced only at 3 months and voice tremor was non-significantly reduced. Activities of daily living were improved in both groups. Changes in medication were moderate. Adverse effects related to the surgery were mild and reversible. CONCLUSIONS—Thalamic stimulation was shown to be an effective and relatively safe treatment for disabling tremor. This procedure initially applied in a very limited number of centres has been successfully used in 13 participating centres.  

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1736277

PubMed: 10084526
PubMed Central: 1736277

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PMC:1736277

Le document en format XML

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<author><name sortKey="Speelman, J" sort="Speelman, J" uniqKey="Speelman J" first="J" last="Speelman">J. Speelman</name>
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<author><name sortKey="Gielen, F" sort="Gielen, F" uniqKey="Gielen F" first="F" last="Gielen">F. Gielen</name>
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<author><name sortKey="Janssens, M" sort="Janssens, M" uniqKey="Janssens M" first="M" last="Janssens">M. Janssens</name>
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<term>Follow-Up Studies</term>
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<term>Male</term>
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<term>Parkinson Disease (physiopathology)</term>
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<front><div type="abstract" xml:lang="en"><p><italic>OBJECTIVES</italic>—Thalamic
stimulation has been proposed to treat disabling tremor. The aims of
this multicentre study were to evaluate the efficacy and the morbidity
of thalamic stimulation in a large number of patients with parkinsonian
or essential tremor. <italic>METHODS</italic>—One hundred
and eleven patients were included in the study and 110 were
implanted either unilaterally or bilaterally. Patients were evaluated
with clinical scales, before and up to 12 months after surgery. <italic>RESULTS</italic>—Upper
and lower limb tremor scores were reduced in both groups. Eighty five
per cent of the electrodes satisfied the arbitrary criteria of two
point reduction in rest tremor reduction in the parkinsonian tremor
group and 89% for postural tremor reduction in the essential tremor
group. In the parkinsonian tremor group, limb akinesia and limb
rigidity scores were moderately but significantly reduced. Axial scores
were unchanged. In the essential tremor group, head tremor was
significantly reduced only at 3 months and voice tremor was
non-significantly reduced. Activities of daily living were improved in
both groups. Changes in medication were moderate. Adverse effects
related to the surgery were mild and reversible. <italic>CONCLUSIONS</italic>—Thalamic
stimulation was shown to be an effective and relatively safe treatment
for disabling tremor. This procedure initially applied in a very
limited number of centres has been successfully used in 13 participating centres.  </p>
</div>
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<front><div type="abstract" xml:lang="en"><p><italic>OBJECTIVES</italic>—Thalamic
stimulation has been proposed to treat disabling tremor. The aims of
this multicentre study were to evaluate the efficacy and the morbidity
of thalamic stimulation in a large number of patients with parkinsonian
or essential tremor. <italic>METHODS</italic>—One hundred
and eleven patients were included in the study and 110 were
implanted either unilaterally or bilaterally. Patients were evaluated
with clinical scales, before and up to 12 months after surgery. <italic>RESULTS</italic>—Upper
and lower limb tremor scores were reduced in both groups. Eighty five
per cent of the electrodes satisfied the arbitrary criteria of two
point reduction in rest tremor reduction in the parkinsonian tremor
group and 89% for postural tremor reduction in the essential tremor
group. In the parkinsonian tremor group, limb akinesia and limb
rigidity scores were moderately but significantly reduced. Axial scores
were unchanged. In the essential tremor group, head tremor was
significantly reduced only at 3 months and voice tremor was
non-significantly reduced. Activities of daily living were improved in
both groups. Changes in medication were moderate. Adverse effects
related to the surgery were mild and reversible. <italic>CONCLUSIONS</italic>—Thalamic
stimulation was shown to be an effective and relatively safe treatment
for disabling tremor. This procedure initially applied in a very
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<front><div type="abstract" xml:lang="en">Thalamic stimulation has been proposed to treat disabling tremor. The aims of this multicentre study were to evaluate the efficacy and the morbidity of thalamic stimulation in a large number of patients with parkinsonian or essential tremor.</div>
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La maladie de Parkinson en France (serveur d'exploration)

Multicentre European study of thalamic stimulation in parkinsonian and essential tremor

Multicentre European study of thalamic stimulation in parkinsonian and essential tremor

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki