High frequency stimulation of the internal Globus Pallidus (GPi) simultaneously improves parkinsonian symptoms and reduces the firing frequency of GPi neurons in the MPTP-treated monkey.
Identifieur interne : 001E32 ( Ncbi/Curation ); précédent : 001E31; suivant : 001E33High frequency stimulation of the internal Globus Pallidus (GPi) simultaneously improves parkinsonian symptoms and reduces the firing frequency of GPi neurons in the MPTP-treated monkey.
Auteurs : T. Boraud [France] ; E. Bezard ; B. Bioulac ; C. GrossSource :
- Neuroscience letters [ 0304-3940 ] ; 1996.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- physiology : Neurons.
- physiopathology : Globus Pallidus, Parkinson Disease.
- Animals, Disease Models, Animal, Macaca mulatta.
Abstract
The firing pattern of the neurons of the internal Globus Pallidus (GPi) is greatly disturbed in Parkinson's disease. Surgical lesion or high frequency stimulation (HFS) of the GPi reduces parkinsonian rigidity and akinesia. We evaluated in this study the effects of HFS of the GPi on the firing pattern of its neurons. Extracellular recordings were carried out under three types of experimental conditions in rhesus monkeys, normal state, after MPTP treatment and during HFS of the GPi. After intracarotidian MPTP injection, the firing rate of GPi cells increased significantly. During HFS, MPTP-induced parkinsonian motor symptoms clearly improved correlatively with a significant decrease in the firing rate of GPi cells in the stimulated area. HFS restored a firing frequency similar to that in normal animals and, unexpectedly, did not completely block neuronal activity.
PubMed: 8880743
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001569
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :001528
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001528
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :001E32
Links to Exploration step
pubmed:8880743Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">High frequency stimulation of the internal Globus Pallidus (GPi) simultaneously improves parkinsonian symptoms and reduces the firing frequency of GPi neurons in the MPTP-treated monkey.</title>
<author><name sortKey="Boraud, T" sort="Boraud, T" uniqKey="Boraud T" first="T" last="Boraud">T. Boraud</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratoire de Neurophysiologie, CNRS UMR 5543, Université de Bordeaux II, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Neurophysiologie, CNRS UMR 5543, Université de Bordeaux II</wicri:regionArea>
<wicri:noRegion>Université de Bordeaux II</wicri:noRegion>
<wicri:noRegion>Université de Bordeaux II</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bezard, E" sort="Bezard, E" uniqKey="Bezard E" first="E" last="Bezard">E. Bezard</name>
</author>
<author><name sortKey="Bioulac, B" sort="Bioulac, B" uniqKey="Bioulac B" first="B" last="Bioulac">B. Bioulac</name>
</author>
<author><name sortKey="Gross, C" sort="Gross, C" uniqKey="Gross C" first="C" last="Gross">C. Gross</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="1996">1996</date>
<idno type="RBID">pubmed:8880743</idno>
<idno type="pmid">8880743</idno>
<idno type="wicri:Area/PubMed/Corpus">001569</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001569</idno>
<idno type="wicri:Area/PubMed/Curation">001528</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001528</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001528</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001528</idno>
<idno type="wicri:Area/Ncbi/Merge">001E32</idno>
<idno type="wicri:Area/Ncbi/Curation">001E32</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">High frequency stimulation of the internal Globus Pallidus (GPi) simultaneously improves parkinsonian symptoms and reduces the firing frequency of GPi neurons in the MPTP-treated monkey.</title>
<author><name sortKey="Boraud, T" sort="Boraud, T" uniqKey="Boraud T" first="T" last="Boraud">T. Boraud</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratoire de Neurophysiologie, CNRS UMR 5543, Université de Bordeaux II, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Neurophysiologie, CNRS UMR 5543, Université de Bordeaux II</wicri:regionArea>
<wicri:noRegion>Université de Bordeaux II</wicri:noRegion>
<wicri:noRegion>Université de Bordeaux II</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bezard, E" sort="Bezard, E" uniqKey="Bezard E" first="E" last="Bezard">E. Bezard</name>
</author>
<author><name sortKey="Bioulac, B" sort="Bioulac, B" uniqKey="Bioulac B" first="B" last="Bioulac">B. Bioulac</name>
</author>
<author><name sortKey="Gross, C" sort="Gross, C" uniqKey="Gross C" first="C" last="Gross">C. Gross</name>
</author>
</analytic>
<series><title level="j">Neuroscience letters</title>
<idno type="ISSN">0304-3940</idno>
<imprint><date when="1996" type="published">1996</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (pharmacology)</term>
<term>Animals</term>
<term>Disease Models, Animal</term>
<term>Globus Pallidus (physiopathology)</term>
<term>Macaca mulatta</term>
<term>Neurons (physiology)</term>
<term>Parkinson Disease (physiopathology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Neurons</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Globus Pallidus</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Disease Models, Animal</term>
<term>Macaca mulatta</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The firing pattern of the neurons of the internal Globus Pallidus (GPi) is greatly disturbed in Parkinson's disease. Surgical lesion or high frequency stimulation (HFS) of the GPi reduces parkinsonian rigidity and akinesia. We evaluated in this study the effects of HFS of the GPi on the firing pattern of its neurons. Extracellular recordings were carried out under three types of experimental conditions in rhesus monkeys, normal state, after MPTP treatment and during HFS of the GPi. After intracarotidian MPTP injection, the firing rate of GPi cells increased significantly. During HFS, MPTP-induced parkinsonian motor symptoms clearly improved correlatively with a significant decrease in the firing rate of GPi cells in the stimulated area. HFS restored a firing frequency similar to that in normal animals and, unexpectedly, did not completely block neuronal activity.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E32 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 001E32 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Ncbi |étape= Curation |type= RBID |clé= pubmed:8880743 |texte= High frequency stimulation of the internal Globus Pallidus (GPi) simultaneously improves parkinsonian symptoms and reduces the firing frequency of GPi neurons in the MPTP-treated monkey. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:8880743" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
![]() | This area was generated with Dilib version V0.6.29. | ![]() |