Delayed response tasks in basal ganglia lesions in man: further evidence for a striato-frontal cooperation in behavioural adaptation.
Identifieur interne : 001E18 ( Ncbi/Curation ); précédent : 001E17; suivant : 001E19Delayed response tasks in basal ganglia lesions in man: further evidence for a striato-frontal cooperation in behavioural adaptation.
Auteurs : A. Partiot [France] ; M. Vérin ; B. Pillon ; C. Teixeira-Ferreira ; Yves Agid [France] ; B. DuboisSource :
- Neuropsychologia [ 0028-3932 ] ; 1996.
English descriptors
- KwdEn :
- Adaptation, Psychological (physiology), Basal Ganglia Diseases (physiopathology), Basal Ganglia Diseases (psychology), Frontal Lobe (physiopathology), Humans, Middle Aged, Neostriatum (physiopathology), Neuropsychological Tests, Parkinson Disease (physiopathology), Parkinson Disease (psychology), Psychomotor Performance (physiology), Reaction Time (physiology), Supranuclear Palsy, Progressive (physiopathology), Supranuclear Palsy, Progressive (psychology), Wechsler Scales.
- MESH :
- physiology : Adaptation, Psychological, Psychomotor Performance, Reaction Time.
- physiopathology : Basal Ganglia Diseases, Frontal Lobe, Neostriatum, Parkinson Disease, Supranuclear Palsy, Progressive.
- psychology : Basal Ganglia Diseases, Parkinson Disease, Supranuclear Palsy, Progressive.
- Humans, Middle Aged, Neuropsychological Tests, Wechsler Scales.
Abstract
To determine the respective contribution of the subcortical structures and the prefrontal cortex in behavioural adaptation, we applied the delayed response paradigm, considered as a functional marker of the dorsolateral region of the prefrontal cortex, to patients with striatal dysfunction: Parkinson's disease (n = 27), progressive supranuclear palsy (n = 20); to patients with prefrontal lesions (n = 10) and to normal control subjects (n = 24). The performance of each group was compared in four experiments: a delayed response task in which the correct answer was previously indicated by an explicit cue (externally guided task); delayed alternation and non-alternation tasks coupled with a delayed reversal task in which the patient had to discover the rule by himself in the absence of explicit cues (internally driven tasks). All groups of patients showed a short-term spatial representational memory deficit in the externally guided situation. Patients with striatal dysfunction showed difficulties in re-engaging attention on a new programme and in maintaining it. However, they did not express the spontaneous tendency to alternate nor the severe difficulties in disengaging from a previous pattern of response demonstrated by patients with prefrontal lesions. These results validate the concept of a striato-frontal functional system in humans and suggest the existence of two different levels of behavioural organization: elaboration of new programmes of behaviour in association with inhibition of previously established ones, that might be under frontal lobe control: maintenance of the new programme until the action has been accomplished and automatization for a routine utilization, that might be under control of the striatum.
PubMed: 8783222
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Vérin</name></author><author><name sortKey="Pillon, B" sort="Pillon, B" uniqKey="Pillon B" first="B" last="Pillon">B. Pillon</name></author><author><name sortKey="Teixeira Ferreira, C" sort="Teixeira Ferreira, C" uniqKey="Teixeira Ferreira C" first="C" last="Teixeira-Ferreira">C. Teixeira-Ferreira</name></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author><author><name sortKey="Dubois, B" sort="Dubois, B" uniqKey="Dubois B" first="B" last="Dubois">B. 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Partiot</name><affiliation wicri:level="3"><nlm:affiliation>INSERM U 289, Centre de Neuropsychologie, Hôpital de la Salpètrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U 289, Centre de Neuropsychologie, Hôpital de la Salpètrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Verin, M" sort="Verin, M" uniqKey="Verin M" first="M" last="Vérin">M. Vérin</name></author><author><name sortKey="Pillon, B" sort="Pillon, B" uniqKey="Pillon B" first="B" last="Pillon">B. Pillon</name></author><author><name sortKey="Teixeira Ferreira, C" sort="Teixeira Ferreira, C" uniqKey="Teixeira Ferreira C" first="C" last="Teixeira-Ferreira">C. Teixeira-Ferreira</name></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author><author><name sortKey="Dubois, B" sort="Dubois, B" uniqKey="Dubois B" first="B" last="Dubois">B. Dubois</name></author></analytic><series><title level="j">Neuropsychologia</title><idno type="ISSN">0028-3932</idno><imprint><date when="1996" type="published">1996</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation, Psychological (physiology)</term><term>Basal Ganglia Diseases (physiopathology)</term><term>Basal Ganglia Diseases (psychology)</term><term>Frontal Lobe (physiopathology)</term><term>Humans</term><term>Middle Aged</term><term>Neostriatum (physiopathology)</term><term>Neuropsychological Tests</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (psychology)</term><term>Psychomotor Performance (physiology)</term><term>Reaction Time (physiology)</term><term>Supranuclear Palsy, Progressive (physiopathology)</term><term>Supranuclear Palsy, Progressive (psychology)</term><term>Wechsler Scales</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Adaptation, Psychological</term><term>Psychomotor Performance</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia Diseases</term><term>Frontal Lobe</term><term>Neostriatum</term><term>Parkinson Disease</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Basal Ganglia Diseases</term><term>Parkinson Disease</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Wechsler Scales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To determine the respective contribution of the subcortical structures and the prefrontal cortex in behavioural adaptation, we applied the delayed response paradigm, considered as a functional marker of the dorsolateral region of the prefrontal cortex, to patients with striatal dysfunction: Parkinson's disease (n = 27), progressive supranuclear palsy (n = 20); to patients with prefrontal lesions (n = 10) and to normal control subjects (n = 24). The performance of each group was compared in four experiments: a delayed response task in which the correct answer was previously indicated by an explicit cue (externally guided task); delayed alternation and non-alternation tasks coupled with a delayed reversal task in which the patient had to discover the rule by himself in the absence of explicit cues (internally driven tasks). All groups of patients showed a short-term spatial representational memory deficit in the externally guided situation. Patients with striatal dysfunction showed difficulties in re-engaging attention on a new programme and in maintaining it. However, they did not express the spontaneous tendency to alternate nor the severe difficulties in disengaging from a previous pattern of response demonstrated by patients with prefrontal lesions. These results validate the concept of a striato-frontal functional system in humans and suggest the existence of two different levels of behavioural organization: elaboration of new programmes of behaviour in association with inhibition of previously established ones, that might be under frontal lobe control: maintenance of the new programme until the action has been accomplished and automatization for a routine utilization, that might be under control of the striatum.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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