Relationship between arterial blood pressure disturbances and alpha adrenoceptor density.
Identifieur interne : 001D13 ( Ncbi/Curation ); précédent : 001D12; suivant : 001D14Relationship between arterial blood pressure disturbances and alpha adrenoceptor density.
Auteurs : M. Galinier [France] ; J M Senard ; P. Valet ; J P Doazan ; G. Durrieu ; M A Tran ; J L Monstastruc ; J P BounhoureSource :
- Clinical and experimental hypertension (New York, N.Y. : 1993) [ 1064-1963 ] ; 1994.
English descriptors
- KwdEn :
- Aged, Arteries (physiopathology), Binding Sites, Blood Platelets (chemistry), Blood Pressure (physiology), Epinephrine (blood), Female, Heart Rate, Humans, Hypertension (physiopathology), Hypotension, Orthostatic (physiopathology), Male, Middle Aged, Norepinephrine (blood), Parkinson Disease (physiopathology), Platelet Aggregation, Receptors, Adrenergic, alpha (physiology).
- MESH :
- chemical , blood : Epinephrine, Norepinephrine.
- chemistry : Blood Platelets.
- physiology : Blood Pressure, Receptors, Adrenergic, alpha.
- physiopathology : Arteries, Hypertension, Hypotension, Orthostatic, Parkinson Disease.
- Aged, Binding Sites, Female, Heart Rate, Humans, Male, Middle Aged, Platelet Aggregation.
Abstract
To investigate the influence of blood pressure disturbances on human platelet alpha 2-adrenoceptor density, we studied 7 normotensive Parkinsonians with orthostatic hypotension and 23 mild essential hypertensive patients. Plasma catecholamine levels were measured by HPLC and alpha 2-adrenoceptor number and affinity determined by [3H]-yohimbine binding. Alpha-adrenergic reactivity was investigated by blood pressure response to noradrenaline infusion in Parkinsonians and by adrenaline-induced platelet aggregation in hypertensive patients. In Parkinsonians with orthostatic hypotension, in comparison with Parkinsonians without orthostatic hypotension and normotensive control subjects age and sex matched, noradrenaline plasma levels were significantly lower (62 +/- 11, 195 +/- 14 and 219 +/- 13 pg. ml-1 respectively, p < 0.05), platelet alpha 2-adrenoceptor number was significantly higher (313 +/- 52, 168 +/- 9 and 174 +/- 4 fmol.mg-1 protein respectively, p < 0.05) and the noradrenaline dose required for a 25 mm Hg increase of systolic blood pressure significantly lower (0.19 +/- 0.03, 0.86 +/- 0.11 and 0.68 +/- 0.10 microgram.Kg-1 respectively, p < 0.05). In hypertensive patients, in comparison with normotensive control subjects age and sex matched, plasma noradrenaline levels remained unchanged (306 +/- 68 vs 246 +/- 28 pg.ml-1) whereas both platelet alpha 2-adrenoceptor number (137 +/- 15 vs 177 +/- 15 fmol.mg-1 protein, p < 0.05) and velocity of adrenaline-induced platelet aggregation were significantly decreased. These results indicate that platelet alpha 2-adrenoceptor density is related to blood pressure values. In Parkinsonians with orthostatic hypotension, the up-regulation of alpha 2-adrenoceptors was induced by the decrease of endogenous catecholamines. In contrast, in essential hypertension a down-regulation of alpha 2-adrenoceptors was observed in spite of no significant increase of catecholamine levels. These results suggest that only sustained abnormal plasma noradrenaline levels could allow the development of alpha 2-adrenoceptor regulatory mechanisms.
PubMed: 8038761
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Valet</name></author><author><name sortKey="Doazan, J P" sort="Doazan, J P" uniqKey="Doazan J" first="J P" last="Doazan">J P Doazan</name></author><author><name sortKey="Durrieu, G" sort="Durrieu, G" uniqKey="Durrieu G" first="G" last="Durrieu">G. 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Galinier</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, Rangueil Hospital, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Cardiology, Rangueil Hospital, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Senard, J M" sort="Senard, J M" uniqKey="Senard J" first="J M" last="Senard">J M Senard</name></author><author><name sortKey="Valet, P" sort="Valet, P" uniqKey="Valet P" first="P" last="Valet">P. Valet</name></author><author><name sortKey="Doazan, J P" sort="Doazan, J P" uniqKey="Doazan J" first="J P" last="Doazan">J P Doazan</name></author><author><name sortKey="Durrieu, G" sort="Durrieu, G" uniqKey="Durrieu G" first="G" last="Durrieu">G. Durrieu</name></author><author><name sortKey="Tran, M A" sort="Tran, M A" uniqKey="Tran M" first="M A" last="Tran">M A Tran</name></author><author><name sortKey="Monstastruc, J L" sort="Monstastruc, J L" uniqKey="Monstastruc J" first="J L" last="Monstastruc">J L Monstastruc</name></author><author><name sortKey="Bounhoure, J P" sort="Bounhoure, J P" uniqKey="Bounhoure J" first="J P" last="Bounhoure">J P Bounhoure</name></author></analytic><series><title level="j">Clinical and experimental hypertension (New York, N.Y. : 1993)</title><idno type="ISSN">1064-1963</idno><imprint><date when="1994" type="published">1994</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Arteries (physiopathology)</term><term>Binding Sites</term><term>Blood Platelets (chemistry)</term><term>Blood Pressure (physiology)</term><term>Epinephrine (blood)</term><term>Female</term><term>Heart Rate</term><term>Humans</term><term>Hypertension (physiopathology)</term><term>Hypotension, Orthostatic (physiopathology)</term><term>Male</term><term>Middle Aged</term><term>Norepinephrine (blood)</term><term>Parkinson Disease (physiopathology)</term><term>Platelet Aggregation</term><term>Receptors, Adrenergic, alpha (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Epinephrine</term><term>Norepinephrine</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Blood Platelets</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blood Pressure</term><term>Receptors, Adrenergic, alpha</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Arteries</term><term>Hypertension</term><term>Hypotension, Orthostatic</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Binding Sites</term><term>Female</term><term>Heart Rate</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Platelet Aggregation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To investigate the influence of blood pressure disturbances on human platelet alpha 2-adrenoceptor density, we studied 7 normotensive Parkinsonians with orthostatic hypotension and 23 mild essential hypertensive patients. Plasma catecholamine levels were measured by HPLC and alpha 2-adrenoceptor number and affinity determined by [3H]-yohimbine binding. Alpha-adrenergic reactivity was investigated by blood pressure response to noradrenaline infusion in Parkinsonians and by adrenaline-induced platelet aggregation in hypertensive patients. In Parkinsonians with orthostatic hypotension, in comparison with Parkinsonians without orthostatic hypotension and normotensive control subjects age and sex matched, noradrenaline plasma levels were significantly lower (62 +/- 11, 195 +/- 14 and 219 +/- 13 pg. ml-1 respectively, p < 0.05), platelet alpha 2-adrenoceptor number was significantly higher (313 +/- 52, 168 +/- 9 and 174 +/- 4 fmol.mg-1 protein respectively, p < 0.05) and the noradrenaline dose required for a 25 mm Hg increase of systolic blood pressure significantly lower (0.19 +/- 0.03, 0.86 +/- 0.11 and 0.68 +/- 0.10 microgram.Kg-1 respectively, p < 0.05). In hypertensive patients, in comparison with normotensive control subjects age and sex matched, plasma noradrenaline levels remained unchanged (306 +/- 68 vs 246 +/- 28 pg.ml-1) whereas both platelet alpha 2-adrenoceptor number (137 +/- 15 vs 177 +/- 15 fmol.mg-1 protein, p < 0.05) and velocity of adrenaline-induced platelet aggregation were significantly decreased. These results indicate that platelet alpha 2-adrenoceptor density is related to blood pressure values. In Parkinsonians with orthostatic hypotension, the up-regulation of alpha 2-adrenoceptors was induced by the decrease of endogenous catecholamines. In contrast, in essential hypertension a down-regulation of alpha 2-adrenoceptors was observed in spite of no significant increase of catecholamine levels. These results suggest that only sustained abnormal plasma noradrenaline levels could allow the development of alpha 2-adrenoceptor regulatory mechanisms.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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