Weight Gain following Pallidal Deep Brain Stimulation: A PET Study
Identifieur interne : 001A06 ( Ncbi/Curation ); précédent : 001A05; suivant : 001A07Weight Gain following Pallidal Deep Brain Stimulation: A PET Study
Auteurs : Paul Sauleau [France] ; Sophie Drapier [France] ; Joan Duprez [France] ; Jean-François Houvenaghel [France] ; Thibaut Dondaine [France] ; Claire Haegelen [France] ; Dominique Drapier [France] ; Pierre Jannin [France] ; Gabriel Robert [France] ; Florence Le Jeune [France] ; Marc Vérin [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- diagnostic imaging : Globus Pallidus.
- metabolism : Globus Pallidus, Parkinson Disease.
- therapy : Parkinson Disease.
- Body Mass Index, Deep Brain Stimulation, Female, Humans, Male, Middle Aged, Positron-Emission Tomography, Weight Gain.
Abstract
The mechanisms behind weight gain following deep brain stimulation (DBS) surgery seem to be multifactorial and suspected depending on the target, either the subthalamic nucleus (STN) or the globus pallidus internus (GPi). Decreased energy expenditure following motor improvement and behavioral and/or metabolic changes are possible explanations. Focusing on GPi target, our objective was to analyze correlations between changes in brain metabolism (measured with PET) and weight gain following GPi-DBS in patients with Parkinson’s disease (PD). Body mass index was calculated and brain activity prospectively measured using 2-deoxy-2[18F]fluoro-D-glucose PET four months before and four months after the start of GPi-DBS in 19 PD patients. Dopaminergic medication was included in the analysis to control for its possible influence on brain metabolism. Body mass index increased significantly by 0.66 ± 1.3 kg/m2 (
Url:
DOI: 10.1371/journal.pone.0153438
PubMed: 27070317
PubMed Central: 4829218
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research unit (EA 4712), University of Rennes 1, Avenue Léon Bernard, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Neurophysiology, Rennes University Hospital, rue Henri Le Guilloux, Rennes, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurophysiology, Rennes University Hospital, rue Henri Le Guilloux, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Drapier, Sophie" sort="Drapier, Sophie" uniqKey="Drapier S" first="Sophie" last="Drapier">Sophie Drapier</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>“Behavior and Basal Ganglia” research unit (EA 4712), University of Rennes 1, Avenue Léon Bernard, Rennes, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>“Behavior and Basal Ganglia” research unit (EA 4712), University of Rennes 1, Avenue Léon Bernard, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Department of Neurology, Rennes University Hospital, rue Henri Le Guilloux, Rennes, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, Rennes University Hospital, rue Henri Le Guilloux, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Duprez, Joan" sort="Duprez, Joan" uniqKey="Duprez J" first="Joan" last="Duprez">Joan Duprez</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>“Behavior and Basal Ganglia” research unit (EA 4712), University of Rennes 1, Avenue Léon Bernard, Rennes, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>“Behavior and Basal Ganglia” research unit (EA 4712), University of Rennes 1, Avenue Léon Bernard, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Houvenaghel, Jean Francois" sort="Houvenaghel, Jean Francois" uniqKey="Houvenaghel J" first="Jean-François" last="Houvenaghel">Jean-François Houvenaghel</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>“Behavior and Basal Ganglia” research unit (EA 4712), University of Rennes 1, Avenue Léon Bernard, Rennes, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>“Behavior and Basal Ganglia” research unit (EA 4712), University of Rennes 1, Avenue Léon Bernard, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Department of Neurology, Rennes University Hospital, rue Henri Le Guilloux, Rennes, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, Rennes University Hospital, rue Henri Le Guilloux, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Dondaine, Thibaut" sort="Dondaine, Thibaut" uniqKey="Dondaine T" first="Thibaut" last="Dondaine">Thibaut Dondaine</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>“Behavior and Basal Ganglia” research unit (EA 4712), University of Rennes 1, Avenue Léon Bernard, Rennes, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>“Behavior and Basal Ganglia” research unit (EA 4712), University of Rennes 1, Avenue Léon Bernard, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Haegelen, Claire" sort="Haegelen, Claire" uniqKey="Haegelen C" first="Claire" last="Haegelen">Claire Haegelen</name><affiliation wicri:level="3"><nlm:aff id="aff004"><addr-line>Department of Neurosurgery, Rennes University Hospital, rue Henri Le Guilloux, Rennes, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurosurgery, Rennes University Hospital, rue Henri Le Guilloux, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff005"><addr-line>“MediCIS” laboratory (UMR 1099 LTSI), INSERM, University of Rennes 1, Avenue Léon Bernard, Rennes, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>“MediCIS” laboratory (UMR 1099 LTSI), INSERM, University of Rennes 1, Avenue Léon Bernard, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Drapier, Dominique" sort="Drapier, Dominique" uniqKey="Drapier D" first="Dominique" last="Drapier">Dominique Drapier</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>“Behavior and Basal Ganglia” research unit (EA 4712), University of Rennes 1, Avenue Léon Bernard, Rennes, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>“Behavior and Basal Ganglia” research unit (EA 4712), University of Rennes 1, Avenue Léon Bernard, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>Department of Psychiatry, Rennes University Hospital, avenue du Général Leclerc, Rennes, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Psychiatry, Rennes University Hospital, avenue du Général Leclerc, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Jannin, Pierre" sort="Jannin, Pierre" uniqKey="Jannin P" first="Pierre" last="Jannin">Pierre Jannin</name><affiliation wicri:level="3"><nlm:aff id="aff004"><addr-line>Department of Neurosurgery, Rennes University Hospital, rue Henri Le Guilloux, Rennes, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurosurgery, Rennes University Hospital, rue Henri Le Guilloux, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Robert, Gabriel" sort="Robert, Gabriel" uniqKey="Robert G" first="Gabriel" last="Robert">Gabriel Robert</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>“Behavior and Basal Ganglia” research unit (EA 4712), University of Rennes 1, Avenue Léon Bernard, Rennes, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>“Behavior and Basal Ganglia” research unit (EA 4712), University of Rennes 1, Avenue Léon Bernard, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>Department of Psychiatry, Rennes University Hospital, avenue du Général Leclerc, Rennes, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Psychiatry, Rennes University Hospital, avenue du Général Leclerc, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Le Jeune, Florence" sort="Le Jeune, Florence" uniqKey="Le Jeune F" first="Florence" last="Le Jeune">Florence Le Jeune</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>“Behavior and Basal Ganglia” research unit (EA 4712), University of Rennes 1, Avenue Léon Bernard, Rennes, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>“Behavior and Basal Ganglia” research unit (EA 4712), University of Rennes 1, Avenue Léon Bernard, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff007"><addr-line>Department of Oncology, Eugene Marquis Center, Avenue de la Bataille Flandres-Dunkerque, Rennes, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Oncology, Eugene Marquis Center, Avenue de la Bataille Flandres-Dunkerque, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Vérin">Marc Vérin</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>“Behavior and Basal Ganglia” research unit (EA 4712), University of Rennes 1, Avenue Léon Bernard, Rennes, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>“Behavior and Basal Ganglia” research unit (EA 4712), University of Rennes 1, Avenue Léon Bernard, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Department of Neurology, Rennes University Hospital, rue Henri Le Guilloux, Rennes, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, Rennes University Hospital, rue Henri Le Guilloux, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Body Mass Index</term><term>Deep Brain Stimulation</term><term>Female</term><term>Globus Pallidus (diagnostic imaging)</term><term>Globus Pallidus (metabolism)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (therapy)</term><term>Positron-Emission Tomography</term><term>Weight Gain</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Globus Pallidus</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Globus Pallidus</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Body Mass Index</term><term>Deep Brain Stimulation</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Positron-Emission Tomography</term><term>Weight Gain</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The mechanisms behind weight gain following deep brain stimulation (DBS) surgery seem to be multifactorial and suspected depending on the target, either the subthalamic nucleus (STN) or the globus pallidus internus (GPi). Decreased energy expenditure following motor improvement and behavioral and/or metabolic changes are possible explanations. Focusing on GPi target, our objective was to analyze correlations between changes in brain metabolism (measured with PET) and weight gain following GPi-DBS in patients with Parkinson’s disease (PD). Body mass index was calculated and brain activity prospectively measured using 2-deoxy-2[18F]fluoro-D-glucose PET four months before and four months after the start of GPi-DBS in 19 PD patients. Dopaminergic medication was included in the analysis to control for its possible influence on brain metabolism. Body mass index increased significantly by 0.66 ± 1.3 kg/m2 (<italic>p</italic> = 0.040). There were correlations between weight gain and changes in brain metabolism in premotor areas, including the left and right superior gyri (Brodmann area, BA 6), left superior gyrus (BA 8), the dorsolateral prefrontal cortex (right middle gyrus, BAs 9 and 46), and the left and right somatosensory association cortices (BA 7). However, we found no correlation between weight gain and metabolic changes in limbic and associative areas. Additionally, there was a trend toward a correlation between reduced dyskinesia and weight gain (<italic>r</italic> = 0.428, <italic>p</italic> = 0.067). These findings suggest that, unlike STN-DBS, motor improvement is the major contributing factor for weight gain following GPi-DBS PD, confirming the motor selectivity of this target.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Aiello, M" uniqKey="Aiello M">M Aiello</name></author><author><name sortKey="Eleopra, R" uniqKey="Eleopra R">R Eleopra</name></author><author><name sortKey="Rumiati, Ri" uniqKey="Rumiati R">RI Rumiati</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kistner, A" uniqKey="Kistner A">A Kistner</name></author><author><name sortKey="Lhommee, E" uniqKey="Lhommee E">E Lhommee</name></author><author><name sortKey="Krack, P" uniqKey="Krack P">P Krack</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barichella, M" uniqKey="Barichella M">M Barichella</name></author><author><name sortKey="Marczewska, Am" uniqKey="Marczewska A">AM 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J" uniqKey="Regis J">J Regis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lhommee, E" uniqKey="Lhommee E">E Lhommee</name></author><author><name sortKey="Klinger, H" uniqKey="Klinger H">H Klinger</name></author><author><name sortKey="Thobois, S" uniqKey="Thobois S">S Thobois</name></author><author><name sortKey="Schmitt, E" uniqKey="Schmitt E">E Schmitt</name></author><author><name sortKey="Ardouin, C" uniqKey="Ardouin C">C Ardouin</name></author><author><name sortKey="Bichon, A" uniqKey="Bichon A">A Bichon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruzicka, F" uniqKey="Ruzicka F">F Ruzicka</name></author><author><name sortKey="Jech, R" uniqKey="Jech R">R Jech</name></author><author><name sortKey="Novakova, L" uniqKey="Novakova L">L Novakova</name></author><author><name sortKey="Urgosik, D" uniqKey="Urgosik D">D Urgosik</name></author><author><name sortKey="Vymazal, J" uniqKey="Vymazal J">J Vymazal</name></author><author><name sortKey="Ruzicka, E" uniqKey="Ruzicka E">E Ruzicka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kelley, Ae" uniqKey="Kelley A">AE Kelley</name></author><author><name sortKey="Baldo, Ba" uniqKey="Baldo B">BA Baldo</name></author><author><name sortKey="Pratt, We" uniqKey="Pratt W">WE Pratt</name></author><author><name sortKey="Will, Mj" uniqKey="Will M">MJ Will</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stratford, Tr" uniqKey="Stratford T">TR Stratford</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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