ParkinsonFranceV1, Ncbi, Curation, bibRecord, 001601

Molecular Interaction between the Chaperone Hsc70 and the N-terminal Flank of Huntingtin Exon 1 Modulates Aggregation*

Identifieur interne : 001601 ( Ncbi/Curation ); précédent : 001600; suivant : 001602

Molecular Interaction between the Chaperone Hsc70 and the N-terminal Flank of Huntingtin Exon 1 Modulates Aggregation*

Auteurs : Elodie Monsellier [France] ; Virginie Redeker [France] ; Gemma Ruiz-Arlandis [France] ; Luc Bousset [France] ; Ronald Melki [France]

Source :

The Journal of Biological Chemistry [ 0021-9258 ] ; 2014.

RBID : PMC:4317008

Abstract

Background: Hsc70 has an alleviating effect on the toxicity of polyglutamine (polyQ)-containing proteins in vivo.

Results: Hsc70 binds specifically the N-terminal flank of huntingtin exon 1.

Conclusion: Hsc70 interaction with huntingtin exon 1 N-terminal flank affects the conformation of the resulting assemblies.

Significance: We identify the surface interfaces between Hsc70 and huntingtin exon 1, which allows the design of future therapeutic tools.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317008

DOI: 10.1074/jbc.M114.603332
PubMed: 25505179
PubMed Central: 4317008

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PMC:4317008

Le document en format XML

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<author><name sortKey="Monsellier, Elodie" sort="Monsellier, Elodie" uniqKey="Monsellier E" first="Elodie" last="Monsellier">Elodie Monsellier</name>
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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
 Hsc70 has an alleviating effect on the toxicity of polyglutamine (polyQ)-containing proteins <italic>in vivo</italic>
.</p>
<p><bold>Results:</bold>
 Hsc70 binds specifically the N-terminal flank of huntingtin exon 1.</p>
<p><bold>Conclusion:</bold>
 Hsc70 interaction with huntingtin exon 1 N-terminal flank affects the conformation of the resulting assemblies.</p>
<p><bold>Significance:</bold>
 We identify the surface interfaces between Hsc70 and huntingtin exon 1, which allows the design of future therapeutic tools.</p>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Molecular Interaction between the Chaperone Hsc70 and the N-terminal Flank of Huntingtin Exon 1 Modulates Aggregation*

Molecular Interaction between the Chaperone Hsc70 and the N-terminal Flank of Huntingtin Exon 1 Modulates Aggregation*

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki