ParkinsonFranceV1, Ncbi, Curation, bibRecord, 001575

Parkinsonism-associated Protein DJ-1/Park7 Is a Major Protein Deglycase That Repairs Methylglyoxal- and Glyoxal-glycated Cysteine, Arginine, and Lysine Residues

Identifieur interne : 001575 ( Ncbi/Curation ); précédent : 001574; suivant : 001576

Parkinsonism-associated Protein DJ-1/Park7 Is a Major Protein Deglycase That Repairs Methylglyoxal- and Glyoxal-glycated Cysteine, Arginine, and Lysine Residues

Auteurs : Gilbert Richarme ; Mouadh Mihoub ; Julien Dairou ; Linh Chi Bui ; Thibaut Leger ; Aazdine Lamouri

Source :

The Journal of Biological Chemistry [ 0021-9258 ] ; 2014.

RBID : PMC:4340429

Abstract

Background: Protein glycation is a nonenzymatic covalent reaction between proteins and carbonyl groups resulting in protein denaturation.

Results: DJ-1 is the first protein deglycase that repairs proteins from glycation by glyoxals, which constitutes most glycation damage.

Conclusion: DJ-1 is a novel protein repair enzyme that protects proteins against glycation.

Significance: DJ-1 deglycase activity changes our view on glycation/deglycation and DJ-1-associated Parkinsonism.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340429

DOI: 10.1074/jbc.M114.597815
PubMed: 25416785
PubMed Central: 4340429

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PMC:4340429

Le document en format XML

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<author><name sortKey="Richarme, Gilbert" sort="Richarme, Gilbert" uniqKey="Richarme G" first="Gilbert" last="Richarme">Gilbert Richarme</name>
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<author><name sortKey="Mihoub, Mouadh" sort="Mihoub, Mouadh" uniqKey="Mihoub M" first="Mouadh" last="Mihoub">Mouadh Mihoub</name>
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<author><name sortKey="Dairou, Julien" sort="Dairou, Julien" uniqKey="Dairou J" first="Julien" last="Dairou">Julien Dairou</name>
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<author><name sortKey="Bui, Linh Chi" sort="Bui, Linh Chi" uniqKey="Bui L" first="Linh Chi" last="Bui">Linh Chi Bui</name>
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<author><name sortKey="Leger, Thibaut" sort="Leger, Thibaut" uniqKey="Leger T" first="Thibaut" last="Leger">Thibaut Leger</name>
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<author><name sortKey="Lamouri, Aazdine" sort="Lamouri, Aazdine" uniqKey="Lamouri A" first="Aazdine" last="Lamouri">Aazdine Lamouri</name>
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<author><name sortKey="Mihoub, Mouadh" sort="Mihoub, Mouadh" uniqKey="Mihoub M" first="Mouadh" last="Mihoub">Mouadh Mihoub</name>
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<author><name sortKey="Dairou, Julien" sort="Dairou, Julien" uniqKey="Dairou J" first="Julien" last="Dairou">Julien Dairou</name>
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<author><name sortKey="Bui, Linh Chi" sort="Bui, Linh Chi" uniqKey="Bui L" first="Linh Chi" last="Bui">Linh Chi Bui</name>
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<author><name sortKey="Lamouri, Aazdine" sort="Lamouri, Aazdine" uniqKey="Lamouri A" first="Aazdine" last="Lamouri">Aazdine Lamouri</name>
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<series><title level="j">The Journal of Biological Chemistry</title>
<idno type="ISSN">0021-9258</idno>
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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
 Protein glycation is a nonenzymatic covalent reaction between proteins and carbonyl groups resulting in protein denaturation.</p>
<p><bold>Results:</bold>
 DJ-1 is the first protein deglycase that repairs proteins from glycation by glyoxals, which constitutes most glycation damage.</p>
<p><bold>Conclusion:</bold>
 DJ-1 is a novel protein repair enzyme that protects proteins against glycation.</p>
<p><bold>Significance:</bold>
 DJ-1 deglycase activity changes our view on glycation/deglycation and DJ-1-associated Parkinsonism.</p>
</div>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Parkinsonism-associated Protein DJ-1/Park7 Is a Major Protein Deglycase That Repairs Methylglyoxal- and Glyoxal-glycated Cysteine, Arginine, and Lysine Residues

Parkinsonism-associated Protein DJ-1/Park7 Is a Major Protein Deglycase That Repairs Methylglyoxal- and Glyoxal-glycated Cysteine, Arginine, and Lysine Residues

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki