ParkinsonFranceV1, Ncbi, Curation, bibRecord, 001574

Identification of Lethal Mutations in Yeast Threonyl-tRNA Synthetase Revealing Critical Residues in Its Human Homolog*

Identifieur interne : 001574 ( Ncbi/Curation ); précédent : 001573; suivant : 001575

Identification of Lethal Mutations in Yeast Threonyl-tRNA Synthetase Revealing Critical Residues in Its Human Homolog*

Auteurs : Zhi-Rong Ruan ; Zhi-Peng Fang ; Qing Ye ; Hui-Yan Lei ; Gilbert Eriani [France] ; Xiao-Long Zhou ; En-Duo Wang

Source :

The Journal of Biological Chemistry [ 0021-9258 ] ; 2014.

RBID : PMC:4340410

Abstract

Background: Eukaryotic ThrRSs exhibit four structural domains similar to bacterial ThrRSs and evolve a eukaryote-specific N-terminal extension domain.

Results: Essential roles of 12 crucial residues in aminoacylation and editing reactions were revealed.

Conclusion: The identified critical residues affected activities of ThrRS in various manners.

Significance: We elucidated the synthetic and editing functions of selected residues and confirmed the functional consistency between yeast and human ThrRSs.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340410

DOI: 10.1074/jbc.M114.599886
PubMed: 25416776
PubMed Central: 4340410

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PMC:4340410

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
 Eukaryotic ThrRSs exhibit four structural domains similar to bacterial ThrRSs and evolve a eukaryote-specific N-terminal extension domain.</p>
<p><bold>Results:</bold>
 Essential roles of 12 crucial residues in aminoacylation and editing reactions were revealed.</p>
<p><bold>Conclusion:</bold>
 The identified critical residues affected activities of ThrRS in various manners.</p>
<p><bold>Significance:</bold>
 We elucidated the synthetic and editing functions of selected residues and confirmed the functional consistency between yeast and human ThrRSs.</p>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Identification of Lethal Mutations in Yeast Threonyl-tRNA Synthetase Revealing Critical Residues in Its Human Homolog*

Identification of Lethal Mutations in Yeast Threonyl-tRNA Synthetase Revealing Critical Residues in Its Human Homolog*

Source :

Abstract

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