Identification of Lethal Mutations in Yeast Threonyl-tRNA Synthetase Revealing Critical Residues in Its Human Homolog*
Identifieur interne : 001574 ( Ncbi/Curation ); précédent : 001573; suivant : 001575Identification of Lethal Mutations in Yeast Threonyl-tRNA Synthetase Revealing Critical Residues in Its Human Homolog*
Auteurs : Zhi-Rong Ruan ; Zhi-Peng Fang ; Qing Ye ; Hui-Yan Lei ; Gilbert Eriani [France] ; Xiao-Long Zhou ; En-Duo WangSource :
- The Journal of Biological Chemistry [ 0021-9258 ] ; 2014.
Abstract
Url:
DOI: 10.1074/jbc.M114.599886
PubMed: 25416776
PubMed Central: 4340410
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Identification of Lethal Mutations in Yeast Threonyl-tRNA Synthetase Revealing Critical Residues in Its Human Homolog<xref ref-type="fn" rid="FN1">*</xref>
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<author><name sortKey="Ruan, Zhi Rong" sort="Ruan, Zhi Rong" uniqKey="Ruan Z" first="Zhi-Rong" last="Ruan">Zhi-Rong Ruan</name>
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<author><name sortKey="Ye, Qing" sort="Ye, Qing" uniqKey="Ye Q" first="Qing" last="Ye">Qing Ye</name>
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<author><name sortKey="Zhou, Xiao Long" sort="Zhou, Xiao Long" uniqKey="Zhou X" first="Xiao-Long" last="Zhou">Xiao-Long Zhou</name>
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<author><name sortKey="Wang, En Duo" sort="Wang, En Duo" uniqKey="Wang E" first="En-Duo" last="Wang">En-Duo Wang</name>
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<series><title level="j">The Journal of Biological Chemistry</title>
<idno type="ISSN">0021-9258</idno>
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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
Eukaryotic ThrRSs exhibit four structural domains similar to bacterial ThrRSs and evolve a eukaryote-specific N-terminal extension domain.</p>
<p><bold>Results:</bold>
Essential roles of 12 crucial residues in aminoacylation and editing reactions were revealed.</p>
<p><bold>Conclusion:</bold>
The identified critical residues affected activities of ThrRS in various manners.</p>
<p><bold>Significance:</bold>
We elucidated the synthetic and editing functions of selected residues and confirmed the functional consistency between yeast and human ThrRSs.</p>
</div>
</front>
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