Spinal Stimulation for Movement Disorders
Identifieur interne : 001455 ( Ncbi/Curation ); précédent : 001454; suivant : 001456Spinal Stimulation for Movement Disorders
Auteurs : Claire Thiriez [France] ; Jean-Marc Gurruchaga [France] ; Colette Goujon [France] ; Gilles Fénelon [France] ; Stéphane Palfi [France]Source :
- Neurotherapeutics [ 1933-7213 ] ; 2014.
Abstract
Epidural spinal cord stimulation (SCS) is currently proposed to treat intractable neuropathic pain. Since the 1970s, isolated cases and small cohorts of patients suffering from dystonia, tremor, painful leg and moving toes (PLMT), or Parkinson’s disease were also treated with SCS in the context of exploratory clinical studies. Despite the safety profile of SCS observed in these various types of movement disorders, the degree of improvement of abnormal movements following SCS has been heterogeneous among patients and across centers in open-label trials, stressing the need for larger, randomized, double-blind studies. This article provides a comprehensive review of both experimental and clinical studies of SCS application in movement disorders.
The online version of this article (doi:10.1007/s13311-014-0291-0) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1007/s13311-014-0291-0
PubMed: 25015323
PubMed Central: 4121450
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Stéphane Palfi<affiliation><nlm:aff id="Aff3">Université Paris Est-Créteil, Faculté de Médecine, 94010 Créteil, Cedex France</nlm:aff>
<wicri:noCountry code="subfield">Cedex France</wicri:noCountry>
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Epidural spinal cord stimulation (SCS) is currently proposed to treat intractable neuropathic pain. Since the 1970s, isolated cases and small cohorts of patients suffering from dystonia, tremor, painful leg and moving toes (PLMT), or Parkinson’s disease were also treated with SCS in the context of exploratory clinical studies. Despite the safety profile of SCS observed in these various types of movement disorders, the degree of improvement of abnormal movements following SCS has been heterogeneous among patients and across centers in open-label trials, stressing the need for larger, randomized, double-blind studies. This article provides a comprehensive review of both experimental and clinical studies of SCS application in movement disorders.</p>
<sec><title>Electronic supplementary material</title>
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