Blood pressure and plasma catecholamines in never-treated parkinsonian patients: effect of a selective D1 agonist (CY 208-243).
Identifieur interne : 001023 ( Ncbi/Curation ); précédent : 001022; suivant : 001024Blood pressure and plasma catecholamines in never-treated parkinsonian patients: effect of a selective D1 agonist (CY 208-243).
Auteurs : G. Durrieu [France] ; J M Senard ; O. Rascol ; M A Tran ; X. Lataste ; A. Rascol ; J L MontastrucSource :
- Neurology [ 0028-3878 ] ; 1990.
English descriptors
- KwdEn :
- Antiparkinson Agents (therapeutic use), Atropine, Blood Pressure (drug effects), Epinephrine (blood), Female, Heart Rate (drug effects), Humans, Indoles (therapeutic use), Male, Middle Aged, Norepinephrine (blood), Parkinson Disease (blood), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Phenanthridines (therapeutic use), Posture, Reference Values.
- MESH :
- chemical , blood : Epinephrine, Norepinephrine.
- chemical , therapeutic use : Antiparkinson Agents, Indoles, Phenanthridines.
- chemical : Atropine.
- blood : Parkinson Disease.
- drug effects : Blood Pressure, Heart Rate.
- drug therapy : Parkinson Disease.
- physiopathology : Parkinson Disease.
- Female, Humans, Male, Middle Aged, Posture, Reference Values.
Abstract
We found blood pressure (BP), heart rate (HR), plasma norepinephrine (NE), and epinephrine (E) levels in the lying and the standing positions to be similar in never-treated parkinsonian patients (stages 1 and 2) and age-matched controls. CY 208-243, a new centrally active D1 agonist, significantly decreased BP, HR, and NE (but not E) values in the lying position; it elicited orthostatic hypotension and blunted the rise in NE elicited by standing up. These results indicate that the early stages of Parkinson's disease are not accompanied by major changes in autonomic cardiovascular function and suggest the involvement of central D1-receptors in the control of sympathetic tone.
PubMed: 2320249
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pubmed:2320249Le document en format XML
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Durrieu</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de Pharmacologie Médicale et Clinique (INSERM U317), Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Pharmacologie Médicale et Clinique (INSERM U317), Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Senard, J M" sort="Senard, J M" uniqKey="Senard J" first="J M" last="Senard">J M Senard</name></author><author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name></author><author><name sortKey="Tran, M A" sort="Tran, M A" uniqKey="Tran M" first="M A" last="Tran">M A Tran</name></author><author><name sortKey="Lataste, X" sort="Lataste, X" uniqKey="Lataste X" first="X" last="Lataste">X. 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Rascol</name></author><author><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J L" last="Montastruc">J L Montastruc</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1990">1990</date><idno type="RBID">pubmed:2320249</idno><idno type="pmid">2320249</idno><idno type="wicri:Area/PubMed/Corpus">001823</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001823</idno><idno type="wicri:Area/PubMed/Curation">001782</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001782</idno><idno type="wicri:Area/PubMed/Checkpoint">001782</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001782</idno><idno type="wicri:Area/Ncbi/Merge">001023</idno><idno type="wicri:Area/Ncbi/Curation">001023</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Blood pressure and plasma catecholamines in never-treated parkinsonian patients: effect of a selective D1 agonist (CY 208-243).</title><author><name sortKey="Durrieu, G" sort="Durrieu, G" uniqKey="Durrieu G" first="G" last="Durrieu">G. Durrieu</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de Pharmacologie Médicale et Clinique (INSERM U317), Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Pharmacologie Médicale et Clinique (INSERM U317), Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Senard, J M" sort="Senard, J M" uniqKey="Senard J" first="J M" last="Senard">J M Senard</name></author><author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name></author><author><name sortKey="Tran, M A" sort="Tran, M A" uniqKey="Tran M" first="M A" last="Tran">M A Tran</name></author><author><name sortKey="Lataste, X" sort="Lataste, X" uniqKey="Lataste X" first="X" last="Lataste">X. 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Rascol</name></author><author><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J L" last="Montastruc">J L Montastruc</name></author></analytic><series><title level="j">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="1990" type="published">1990</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiparkinson Agents (therapeutic use)</term><term>Atropine</term><term>Blood Pressure (drug effects)</term><term>Epinephrine (blood)</term><term>Female</term><term>Heart Rate (drug effects)</term><term>Humans</term><term>Indoles (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Norepinephrine (blood)</term><term>Parkinson Disease (blood)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Phenanthridines (therapeutic use)</term><term>Posture</term><term>Reference Values</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Epinephrine</term><term>Norepinephrine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Indoles</term><term>Phenanthridines</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Atropine</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Blood Pressure</term><term>Heart Rate</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Posture</term><term>Reference Values</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We found blood pressure (BP), heart rate (HR), plasma norepinephrine (NE), and epinephrine (E) levels in the lying and the standing positions to be similar in never-treated parkinsonian patients (stages 1 and 2) and age-matched controls. CY 208-243, a new centrally active D1 agonist, significantly decreased BP, HR, and NE (but not E) values in the lying position; it elicited orthostatic hypotension and blunted the rise in NE elicited by standing up. These results indicate that the early stages of Parkinson's disease are not accompanied by major changes in autonomic cardiovascular function and suggest the involvement of central D1-receptors in the control of sympathetic tone.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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