Age-induced cognitive disturbances in Parkinson's disease.
Identifieur interne : 000F80 ( Ncbi/Curation ); précédent : 000F79; suivant : 000F81Age-induced cognitive disturbances in Parkinson's disease.
Auteurs : B. Dubois [France] ; B. Pillon ; N. Sternic ; F. Lhermitte ; Yves Agid [France]Source :
- Neurology [ 0028-3878 ] ; 1990.
English descriptors
- KwdEn :
- MESH :
- etiology : Cognition Disorders.
- physiopathology : Cognition Disorders, Parkinson Disease.
- psychology : Aging, Cognition Disorders, Parkinson Disease.
- Adult, Aged, Humans, Neuropsychological Tests.
Abstract
We investigated the influence of age on the occurrence of cognitive disturbances in Parkinson's disease (PD), by evaluating neuropsychological performances in early- and late-onset groups of patients (less than 45 and greater than 65 years, respectively), individually paired for all the variables of parkinsonism and compared with age-matched controls. Cognitive disorders were limited in the early-onset PD group compared with their age-matched controls. Conversely, we found global cognitive changes, including marked frontal lobe dysfunction, in the late-onset group. This specific cognitive impairment in older patients related to a significant interaction between the aging and disease processes. Late onset seemed to compound the subtle cognitive changes associated with the disease for which the early-onset group compensated. This compounding effect of aging may explain, at least partially, the high frequency of dementia in older PD patients.
PubMed: 2296380
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Sternic</name></author><author><name sortKey="Lhermitte, F" sort="Lhermitte, F" uniqKey="Lhermitte F" first="F" last="Lhermitte">F. Lhermitte</name></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1990">1990</date><idno type="RBID">pubmed:2296380</idno><idno type="pmid">2296380</idno><idno type="wicri:Area/PubMed/Corpus">001828</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001828</idno><idno type="wicri:Area/PubMed/Curation">001787</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001787</idno><idno type="wicri:Area/PubMed/Checkpoint">001787</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001787</idno><idno type="wicri:Area/Ncbi/Merge">000F80</idno><idno type="wicri:Area/Ncbi/Curation">000F80</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Age-induced cognitive disturbances in Parkinson's disease.</title><author><name sortKey="Dubois, B" sort="Dubois, B" uniqKey="Dubois B" first="B" last="Dubois">B. Dubois</name><affiliation wicri:level="3"><nlm:affiliation>Clinique de Neurologie et Neuropsychologie, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Clinique de Neurologie et Neuropsychologie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Pillon, B" sort="Pillon, B" uniqKey="Pillon B" first="B" last="Pillon">B. Pillon</name></author><author><name sortKey="Sternic, N" sort="Sternic, N" uniqKey="Sternic N" first="N" last="Sternic">N. Sternic</name></author><author><name sortKey="Lhermitte, F" sort="Lhermitte, F" uniqKey="Lhermitte F" first="F" last="Lhermitte">F. Lhermitte</name></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author></analytic><series><title level="j">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="1990" type="published">1990</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aging (psychology)</term><term>Cognition Disorders (etiology)</term><term>Cognition Disorders (physiopathology)</term><term>Cognition Disorders (psychology)</term><term>Humans</term><term>Neuropsychological Tests</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (psychology)</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cognition Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Aging</term><term>Cognition Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Humans</term><term>Neuropsychological Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated the influence of age on the occurrence of cognitive disturbances in Parkinson's disease (PD), by evaluating neuropsychological performances in early- and late-onset groups of patients (less than 45 and greater than 65 years, respectively), individually paired for all the variables of parkinsonism and compared with age-matched controls. Cognitive disorders were limited in the early-onset PD group compared with their age-matched controls. Conversely, we found global cognitive changes, including marked frontal lobe dysfunction, in the late-onset group. This specific cognitive impairment in older patients related to a significant interaction between the aging and disease processes. Late onset seemed to compound the subtle cognitive changes associated with the disease for which the early-onset group compensated. This compounding effect of aging may explain, at least partially, the high frequency of dementia in older PD patients.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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