Age-induced cognitive disturbances in Parkinson's disease.
Identifieur interne : 000F80 ( Ncbi/Curation ); précédent : 000F79; suivant : 000F81Age-induced cognitive disturbances in Parkinson's disease.
Auteurs : B. Dubois [France] ; B. Pillon ; N. Sternic ; F. Lhermitte ; Yves Agid [France]Source :
- Neurology [ 0028-3878 ] ; 1990.
English descriptors
- KwdEn :
- MESH :
- etiology : Cognition Disorders.
- physiopathology : Cognition Disorders, Parkinson Disease.
- psychology : Aging, Cognition Disorders, Parkinson Disease.
- Adult, Aged, Humans, Neuropsychological Tests.
Abstract
We investigated the influence of age on the occurrence of cognitive disturbances in Parkinson's disease (PD), by evaluating neuropsychological performances in early- and late-onset groups of patients (less than 45 and greater than 65 years, respectively), individually paired for all the variables of parkinsonism and compared with age-matched controls. Cognitive disorders were limited in the early-onset PD group compared with their age-matched controls. Conversely, we found global cognitive changes, including marked frontal lobe dysfunction, in the late-onset group. This specific cognitive impairment in older patients related to a significant interaction between the aging and disease processes. Late onset seemed to compound the subtle cognitive changes associated with the disease for which the early-onset group compensated. This compounding effect of aging may explain, at least partially, the high frequency of dementia in older PD patients.
PubMed: 2296380
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pubmed:2296380Le document en format XML
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<front><div type="abstract" xml:lang="en">We investigated the influence of age on the occurrence of cognitive disturbances in Parkinson's disease (PD), by evaluating neuropsychological performances in early- and late-onset groups of patients (less than 45 and greater than 65 years, respectively), individually paired for all the variables of parkinsonism and compared with age-matched controls. Cognitive disorders were limited in the early-onset PD group compared with their age-matched controls. Conversely, we found global cognitive changes, including marked frontal lobe dysfunction, in the late-onset group. This specific cognitive impairment in older patients related to a significant interaction between the aging and disease processes. Late onset seemed to compound the subtle cognitive changes associated with the disease for which the early-onset group compensated. This compounding effect of aging may explain, at least partially, the high frequency of dementia in older PD patients.</div>
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