Role of Basal Ganglia Circuits in Resisting Interference by Distracters: A swLORETA Study
Identifieur interne : 000E85 ( Ncbi/Curation ); précédent : 000E84; suivant : 000E86Role of Basal Ganglia Circuits in Resisting Interference by Distracters: A swLORETA Study
Auteurs : Perrine Bocquillon [France] ; Jean-Louis Bourriez [France] ; Ernesto Palmero-Soler [Allemagne] ; Alain Destée [France] ; Luc Defebvre [France] ; Philippe Derambure [France] ; Kathy Dujardin [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- physiology : Event-Related Potentials, P300.
- physiopathology : Basal Ganglia, Parkinson Disease.
- Aged, Behavior, Case-Control Studies, Electroencephalography, Female, Humans, Male, Middle Aged, Reaction Time, Software, Tomography, X-Ray Computed.
Abstract
The selection of task-relevant information requires both the focalization of attention on the task and resistance to interference from irrelevant stimuli. Both mechanisms rely on a dorsal frontoparietal network, while focalization additionally involves a ventral frontoparietal network. The role of subcortical structures in attention is less clear, despite the fact that the striatum interacts significantly with the frontal cortex via frontostriatal loops. One means of investigating the basal ganglia's contributions to attention is to examine the features of P300 components (i.e. amplitude, latency, and generators) in patients with basal ganglia damage (such as in Parkinson's disease (PD), in which attention is often impaired). Three-stimulus oddball paradigms can be used to study distracter-elicited and target-elicited P300 subcomponents.
In order to compare distracter- and target-elicited P300 components, high-density (128-channel) electroencephalograms were recorded during a three-stimulus visual oddball paradigm in 15 patients with early PD and 15 matched healthy controls. For each subject, the P300 sources were localized using standardized weighted low-resolution electromagnetic tomography (swLORETA). Comparative analyses (one-sample and two-sample t-tests) were performed using SPM5® software. The swLORETA analyses showed that PD patients displayed fewer dorsolateral prefrontal (DLPF) distracter-P300 generators but no significant differences in target-elicited P300 sources; this suggests dysfunction of the DLPF cortex when the executive frontostriatal loop is disrupted by basal ganglia damage.
Our results suggest that the cortical attention frontoparietal networks (mainly the dorsal one) are modulated by the basal ganglia. Disruption of this network in PD impairs resistance to distracters, which results in attention disorders.
Url:
DOI: 10.1371/journal.pone.0034239
PubMed: 22470542
PubMed Central: 3314607
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Neurosciences Fonctionnelles et Pathologies, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Lab. Neurosciences Fonctionnelles et Pathologies, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Clinical Neurophysiology Department, Lille University Medical Center, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Clinical Neurophysiology Department, Lille University Medical Center, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Bourriez, Jean Louis" sort="Bourriez, Jean Louis" uniqKey="Bourriez J" first="Jean-Louis" last="Bourriez">Jean-Louis Bourriez</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Lab. Neurosciences Fonctionnelles et Pathologies, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Lab. Neurosciences Fonctionnelles et Pathologies, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Clinical Neurophysiology Department, Lille University Medical Center, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Clinical Neurophysiology Department, Lille University Medical Center, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Palmero Soler, Ernesto" sort="Palmero Soler, Ernesto" uniqKey="Palmero Soler E" first="Ernesto" last="Palmero-Soler">Ernesto Palmero-Soler</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Eemagine Medical Imaging Solutions GmbH, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Eemagine Medical Imaging Solutions GmbH, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>University of Lille Nord de France, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University of Lille Nord de France, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>Neurology and Movement Disorders Department, Lille University Medical Center, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Neurology and Movement Disorders Department, Lille University Medical Center, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author><author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>University of Lille Nord de France, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University of Lille Nord de France, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Lab. Neurosciences Fonctionnelles et Pathologies, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Lab. 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Neurosciences Fonctionnelles et Pathologies, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Lab. Neurosciences Fonctionnelles et Pathologies, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Clinical Neurophysiology Department, Lille University Medical Center, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Clinical Neurophysiology Department, Lille University Medical Center, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>University of Lille Nord de France, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University of Lille Nord de France, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Lab. Neurosciences Fonctionnelles et Pathologies, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Lab. Neurosciences Fonctionnelles et Pathologies, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>Neurology and Movement Disorders Department, Lille University Medical Center, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Neurology and Movement Disorders Department, Lille University Medical Center, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Basal Ganglia (physiopathology)</term><term>Behavior</term><term>Case-Control Studies</term><term>Electroencephalography</term><term>Event-Related Potentials, P300 (physiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (physiopathology)</term><term>Reaction Time</term><term>Software</term><term>Tomography, X-Ray Computed</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Event-Related Potentials, P300</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Behavior</term><term>Case-Control Studies</term><term>Electroencephalography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Reaction Time</term><term>Software</term><term>Tomography, X-Ray Computed</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The selection of task-relevant information requires both the focalization of attention on the task and resistance to interference from irrelevant stimuli. Both mechanisms rely on a dorsal frontoparietal network, while focalization additionally involves a ventral frontoparietal network. The role of subcortical structures in attention is less clear, despite the fact that the striatum interacts significantly with the frontal cortex via frontostriatal loops. One means of investigating the basal ganglia's contributions to attention is to examine the features of P300 components (i.e. amplitude, latency, and generators) in patients with basal ganglia damage (such as in Parkinson's disease (PD), in which attention is often impaired). Three-stimulus oddball paradigms can be used to study distracter-elicited and target-elicited P300 subcomponents.</p></sec><sec><title>Methodology/Principal Findings</title><p>In order to compare distracter- and target-elicited P300 components, high-density (128-channel) electroencephalograms were recorded during a three-stimulus visual oddball paradigm in 15 patients with early PD and 15 matched healthy controls. For each subject, the P300 sources were localized using standardized weighted low-resolution electromagnetic tomography (swLORETA). Comparative analyses (one-sample and two-sample t-tests) were performed using SPM5® software. The swLORETA analyses showed that PD patients displayed fewer dorsolateral prefrontal (DLPF) distracter-P300 generators but no significant differences in target-elicited P300 sources; this suggests dysfunction of the DLPF cortex when the executive frontostriatal loop is disrupted by basal ganglia damage.</p></sec><sec><title>Conclusions/Significance</title><p>Our results suggest that the cortical attention frontoparietal networks (mainly the dorsal one) are modulated by the basal ganglia. 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Leimpeter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Lau, Lm" uniqKey="De Lau L">LM de Lau</name></author><author><name sortKey="Giesbergen, Pc" uniqKey="Giesbergen P">PC Giesbergen</name></author><author><name sortKey="De Rijk, Mc" uniqKey="De Rijk M">MC de Rijk</name></author><author><name sortKey="Hofman, A" uniqKey="Hofman A">A Hofman</name></author><author><name sortKey="Koudstaal, Pj" uniqKey="Koudstaal P">PJ Koudstaal</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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