Effects of varying subthalamic nucleus stimulation on apraxia of lid opening in Parkinson's disease.
Identifieur interne : 000E56 ( Ncbi/Curation ); précédent : 000E55; suivant : 000E57Effects of varying subthalamic nucleus stimulation on apraxia of lid opening in Parkinson's disease.
Auteurs : Giorgio Tommasi [France] ; Paul Krack ; Valérie Fraix ; Pierre PollakSource :
- Journal of neurology [ 1432-1459 ] ; 2012.
English descriptors
- KwdEn :
- Apraxias (etiology), Biophysical Phenomena (physiology), Electric Stimulation Therapy (methods), Eyelids (physiopathology), Female, Functional Laterality, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (therapy), Subthalamic Nucleus (physiology).
- MESH :
- complications : Parkinson Disease.
- etiology : Apraxias.
- methods : Electric Stimulation Therapy.
- physiology : Biophysical Phenomena, Subthalamic Nucleus.
- physiopathology : Eyelids.
- therapy : Parkinson Disease.
- Female, Functional Laterality, Humans, Magnetic Resonance Imaging, Male, Middle Aged.
Abstract
Apraxia of lid opening (ALO) is a non-paralytic inability to open the eyes or sustain lid elevation at will. The exact pathophysiological mechanisms underlying the syndrome are still unknown. ALO has been reported in patients with Parkinson's disease (PD) after subthalamic nucleus (STN) deep brain stimulation (DBS), suggesting a possible involvement of the basal ganglia. We aimed to assess the effects of varying STN stimulation voltage on ALO in PD patients. Seven out of 14 PD patients with bilateral STN stimulation consecutively seen in our centre presented with ALO. We progressively increased voltage on each STN, using either 130 Hz (high-frequency stimulation, HFS) or 2 or 3 Hz (low-frequency stimulation, LFS). In five patients, HFS induced ALO time-locked to stimulation in 7 out of 10 STNs at a voltage higher than that used for chronic stimulation. LFS induced myoclonus in the pretarsal orbicularis oculi muscle (pOOm) with a rhythm synchronous to the frequency. In the other two patients with ALO already present at the time of the study, HFS improved ALO in 3 out of 4 STNs. ALO recurred within minutes of stimulation arrest. Our findings show that STN-DBS can have opposite effects on ALO. On the one hand, ALO is thought to be a corticobulbar side effect due to lateral current spreading from the STN, in which case it is necessary to use voltages below the ALO-inducing threshold. On the other hand, ALO may be considered a form of off-phase focal dystonia possibly improved by increasing the stimulation voltages.
DOI: 10.1007/s00415-012-6447-0
PubMed: 22349870
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000833
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000797
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000797
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000E56
Links to Exploration step
pubmed:22349870Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of varying subthalamic nucleus stimulation on apraxia of lid opening in Parkinson's disease.</title>
<author><name sortKey="Tommasi, Giorgio" sort="Tommasi, Giorgio" uniqKey="Tommasi G" first="Giorgio" last="Tommasi">Giorgio Tommasi</name>
<affiliation wicri:level="3"><nlm:affiliation>Département de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France. giorgio.tommasi@ospedaleuniverona.it</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Département de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name>
</author>
<author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name>
</author>
<author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2012">2012</date>
<idno type="RBID">pubmed:22349870</idno>
<idno type="pmid">22349870</idno>
<idno type="doi">10.1007/s00415-012-6447-0</idno>
<idno type="wicri:Area/PubMed/Corpus">000833</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000833</idno>
<idno type="wicri:Area/PubMed/Curation">000797</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000797</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000797</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000797</idno>
<idno type="wicri:Area/Ncbi/Merge">000E56</idno>
<idno type="wicri:Area/Ncbi/Curation">000E56</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Effects of varying subthalamic nucleus stimulation on apraxia of lid opening in Parkinson's disease.</title>
<author><name sortKey="Tommasi, Giorgio" sort="Tommasi, Giorgio" uniqKey="Tommasi G" first="Giorgio" last="Tommasi">Giorgio Tommasi</name>
<affiliation wicri:level="3"><nlm:affiliation>Département de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France. giorgio.tommasi@ospedaleuniverona.it</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Département de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name>
</author>
<author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name>
</author>
<author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name>
</author>
</analytic>
<series><title level="j">Journal of neurology</title>
<idno type="eISSN">1432-1459</idno>
<imprint><date when="2012" type="published">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Apraxias (etiology)</term>
<term>Biophysical Phenomena (physiology)</term>
<term>Electric Stimulation Therapy (methods)</term>
<term>Eyelids (physiopathology)</term>
<term>Female</term>
<term>Functional Laterality</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (therapy)</term>
<term>Subthalamic Nucleus (physiology)</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Apraxias</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electric Stimulation Therapy</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Biophysical Phenomena</term>
<term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Eyelids</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Female</term>
<term>Functional Laterality</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Apraxia of lid opening (ALO) is a non-paralytic inability to open the eyes or sustain lid elevation at will. The exact pathophysiological mechanisms underlying the syndrome are still unknown. ALO has been reported in patients with Parkinson's disease (PD) after subthalamic nucleus (STN) deep brain stimulation (DBS), suggesting a possible involvement of the basal ganglia. We aimed to assess the effects of varying STN stimulation voltage on ALO in PD patients. Seven out of 14 PD patients with bilateral STN stimulation consecutively seen in our centre presented with ALO. We progressively increased voltage on each STN, using either 130 Hz (high-frequency stimulation, HFS) or 2 or 3 Hz (low-frequency stimulation, LFS). In five patients, HFS induced ALO time-locked to stimulation in 7 out of 10 STNs at a voltage higher than that used for chronic stimulation. LFS induced myoclonus in the pretarsal orbicularis oculi muscle (pOOm) with a rhythm synchronous to the frequency. In the other two patients with ALO already present at the time of the study, HFS improved ALO in 3 out of 4 STNs. ALO recurred within minutes of stimulation arrest. Our findings show that STN-DBS can have opposite effects on ALO. On the one hand, ALO is thought to be a corticobulbar side effect due to lateral current spreading from the STN, in which case it is necessary to use voltages below the ALO-inducing threshold. On the other hand, ALO may be considered a form of off-phase focal dystonia possibly improved by increasing the stimulation voltages.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E56 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000E56 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Ncbi |étape= Curation |type= RBID |clé= pubmed:22349870 |texte= Effects of varying subthalamic nucleus stimulation on apraxia of lid opening in Parkinson's disease. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:22349870" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
This area was generated with Dilib version V0.6.29. |