La maladie de Parkinson en France (serveur d'exploration)

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Piribedil-induced sleep attacks in patients without Parkinson disease: a case series.

Identifieur interne : 000D18 ( Ncbi/Curation ); précédent : 000D17; suivant : 000D19

Piribedil-induced sleep attacks in patients without Parkinson disease: a case series.

Auteurs : Aurore Gouraud [France] ; Anne Millaret ; Jacques Descotes ; Thierry Vial

Source :

RBID : pubmed:21586915

English descriptors

Abstract

Sleep attacks were initially described in 1999 in patients with Parkinson disease (PD) treated by dopamine agonists (DAs). Because the respective role of DAs or PD-induced excessive daytime sleepiness is still unclear, reports of sleep attacks in non-PD patients treated with DA would support the specific role of these drugs. Piribedil, a nonergot dopamine D2/D3 agonist with alpha(2)-noradrenergic properties, is indicated in the treatment of PD as well as in patients with circulatory disorders. After a spontaneous report of sleep attack associated with piribedil use in a non-PD patient, we reviewed other cases from the French pharmacovigilance database.

DOI: 10.1097/WNF.0b013e31821f0d8b
PubMed: 21586915

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Le document en format XML

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<nlm:affiliation>Poison Center and Pharmacovigilance Department, Lyon University Hospitals, Lyon, France. aurore.gouraud@chu-lyon.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Poison Center and Pharmacovigilance Department, Lyon University Hospitals, Lyon</wicri:regionArea>
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<region type="region">Auvergne-Rhône-Alpes</region>
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<term>Aged</term>
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<term>Antiparkinson Agents (adverse effects)</term>
<term>Databases, Factual</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (drug therapy)</term>
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<term>Piribedil (adverse effects)</term>
<term>Sleep Wake Disorders (chemically induced)</term>
<term>Sleep Wake Disorders (physiopathology)</term>
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<term>Antiparkinson Agents</term>
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<div type="abstract" xml:lang="en">Sleep attacks were initially described in 1999 in patients with Parkinson disease (PD) treated by dopamine agonists (DAs). Because the respective role of DAs or PD-induced excessive daytime sleepiness is still unclear, reports of sleep attacks in non-PD patients treated with DA would support the specific role of these drugs. Piribedil, a nonergot dopamine D2/D3 agonist with alpha(2)-noradrenergic properties, is indicated in the treatment of PD as well as in patients with circulatory disorders. After a spontaneous report of sleep attack associated with piribedil use in a non-PD patient, we reviewed other cases from the French pharmacovigilance database.</div>
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