Piribedil-induced sleep attacks in patients without Parkinson disease: a case series.
Identifieur interne : 000D18 ( Ncbi/Curation ); précédent : 000D17; suivant : 000D19Piribedil-induced sleep attacks in patients without Parkinson disease: a case series.
Auteurs : Aurore Gouraud [France] ; Anne Millaret ; Jacques Descotes ; Thierry VialSource :
- Clinical neuropharmacology [ 1537-162X ]
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Antiparkinson Agents (adverse effects), Databases, Factual, Female, Humans, Male, Middle Aged, Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Piribedil (adverse effects), Sleep Wake Disorders (chemically induced), Sleep Wake Disorders (physiopathology).
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Piribedil.
- chemically induced : Sleep Wake Disorders.
- drug therapy : Parkinson Disease.
- physiopathology : Parkinson Disease, Sleep Wake Disorders.
- Aged, Aged, 80 and over, Databases, Factual, Female, Humans, Male, Middle Aged.
Abstract
Sleep attacks were initially described in 1999 in patients with Parkinson disease (PD) treated by dopamine agonists (DAs). Because the respective role of DAs or PD-induced excessive daytime sleepiness is still unclear, reports of sleep attacks in non-PD patients treated with DA would support the specific role of these drugs. Piribedil, a nonergot dopamine D2/D3 agonist with alpha(2)-noradrenergic properties, is indicated in the treatment of PD as well as in patients with circulatory disorders. After a spontaneous report of sleep attack associated with piribedil use in a non-PD patient, we reviewed other cases from the French pharmacovigilance database.
DOI: 10.1097/WNF.0b013e31821f0d8b
PubMed: 21586915
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pubmed:21586915Le document en format XML
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<front><div type="abstract" xml:lang="en">Sleep attacks were initially described in 1999 in patients with Parkinson disease (PD) treated by dopamine agonists (DAs). Because the respective role of DAs or PD-induced excessive daytime sleepiness is still unclear, reports of sleep attacks in non-PD patients treated with DA would support the specific role of these drugs. Piribedil, a nonergot dopamine D2/D3 agonist with alpha(2)-noradrenergic properties, is indicated in the treatment of PD as well as in patients with circulatory disorders. After a spontaneous report of sleep attack associated with piribedil use in a non-PD patient, we reviewed other cases from the French pharmacovigilance database.</div>
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