Regional characterization of energy metabolism in the brain of normal and MPTP-intoxicated mice using new markers of glucose and phosphate transport
Identifieur interne : 000C57 ( Ncbi/Curation ); précédent : 000C56; suivant : 000C58Regional characterization of energy metabolism in the brain of normal and MPTP-intoxicated mice using new markers of glucose and phosphate transport
Auteurs : Emmanuelle Lagrue [France] ; Hiroyuki Abe [France, Japon] ; Madakasira Lavanya [France, États-Unis] ; Jawida Touhami [France] ; Sylvie Bodard [France] ; Sylvie Chalon [France] ; Jean-Luc Battini [France] ; Marc Sitbon [France] ; Pierre Castelnau [France]Source :
- Journal of Biomedical Science [ 1021-7770 ] ; 2010.
Abstract
The gibbon ape leukemia virus (GALV), the amphotropic murine leukemia virus (AMLV) and the human T-cell leukemia virus (HTLV) are retroviruses that specifically bind nutrient transporters with their envelope glycoproteins (Env) when entering host cells. Here, we used tagged ligands derived from GALV, AMLV, and HTLV Env to monitor the distribution of their cognate receptors, the inorganic phosphate transporters PiT1 and PiT2, and the glucose transporter GLUT1, respectively, in basal conditions and after acute energy deficiency. For this purpose, we monitored changes in the distribution of PiT1, PiT2 and GLUT1 in the cerebellum, the frontal cortex, the corpus callosum, the striatum and the substantia nigra (SN) of C57/BL6 mice after administration of 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridinium (MPTP), a mitochondrial complex I inhibitor which induces neuronal degeneration in the striato-nigral network.
The PiT1 ligand stained oligodendrocytes in the corpus callosum and showed a reticular pattern in the SN. The PiT2 ligand stained particularly the cerebellar Purkinje cells, while GLUT1 labelling was mainly observed throughout the cortex, basal ganglia and cerebellar gray matter. Interestingly, unlike GLUT1 and PiT2 distributions which did not appear to be modified by MPTP intoxication, PiT1 immunostaining seemed to be more extended in the SN. The plausible reasons for this change following acute energy stress are discussed.
These new ligands therefore constitute new metabolic markers which should help to unravel cellular adaptations to a wide variety of normal and pathologic conditions and to determine the role of specific nutrient transporters in tissue homeostasis.
Url:
DOI: 10.1186/1423-0127-17-91
PubMed: 21129221
PubMed Central: 3009624
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PMC:3009624Le document en format XML
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<affiliation wicri:level="3"><nlm:aff id="I4">Institut de Génétique Moléculaire de Montpellier, CNRS UMR 5535, 1919 Route de Mende, Montpellier Cedex 5, F-34293 France</nlm:aff>
<country wicri:rule="zip">France</country>
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<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
<settlement type="city">France</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="I5">Université de Montpellier 1 et 2, Place Eugène Bataillon, Montpellier, 34293 France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Montpellier 1 et 2, Place Eugène Bataillon, Montpellier</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bodard, Sylvie" sort="Bodard, Sylvie" uniqKey="Bodard S" first="Sylvie" last="Bodard">Sylvie Bodard</name>
<affiliation wicri:level="4"><nlm:aff id="I1">UMR Inserm U 930, CNRS FRE 2448, Université François Rabelais de Tours, F-37044 Tours, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>UMR Inserm U 930, CNRS FRE 2448, Université François Rabelais de Tours, F-37044 Tours</wicri:regionArea>
<placeName><region type="region" nuts="2">Centre-Val de Loire</region>
<region type="old region" nuts="2">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
<orgName type="university">Université François-Rabelais de Tours</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="I2">Université François Rabelais de Tours, F-37044 Tours, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université François Rabelais de Tours, F-37044 Tours</wicri:regionArea>
<placeName><region type="region" nuts="2">Centre-Val de Loire</region>
<region type="old region" nuts="2">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
<orgName type="university">Université François-Rabelais de Tours</orgName>
</affiliation>
</author>
<author><name sortKey="Chalon, Sylvie" sort="Chalon, Sylvie" uniqKey="Chalon S" first="Sylvie" last="Chalon">Sylvie Chalon</name>
<affiliation wicri:level="4"><nlm:aff id="I1">UMR Inserm U 930, CNRS FRE 2448, Université François Rabelais de Tours, F-37044 Tours, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>UMR Inserm U 930, CNRS FRE 2448, Université François Rabelais de Tours, F-37044 Tours</wicri:regionArea>
<placeName><region type="region" nuts="2">Centre-Val de Loire</region>
<region type="old region" nuts="2">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
<orgName type="university">Université François-Rabelais de Tours</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="I2">Université François Rabelais de Tours, F-37044 Tours, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université François Rabelais de Tours, F-37044 Tours</wicri:regionArea>
<placeName><region type="region" nuts="2">Centre-Val de Loire</region>
<region type="old region" nuts="2">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
<orgName type="university">Université François-Rabelais de Tours</orgName>
</affiliation>
</author>
<author><name sortKey="Battini, Jean Luc" sort="Battini, Jean Luc" uniqKey="Battini J" first="Jean-Luc" last="Battini">Jean-Luc Battini</name>
<affiliation wicri:level="3"><nlm:aff id="I4">Institut de Génétique Moléculaire de Montpellier, CNRS UMR 5535, 1919 Route de Mende, Montpellier Cedex 5, F-34293 France</nlm:aff>
<country wicri:rule="zip">France</country>
<wicri:regionArea>Institut de Génétique Moléculaire de Montpellier, CNRS UMR 5535, 1919 Route de Mende, Montpellier Cedex 5, F-34293 France</wicri:regionArea>
<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
<settlement type="city">France</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="I5">Université de Montpellier 1 et 2, Place Eugène Bataillon, Montpellier, 34293 France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Montpellier 1 et 2, Place Eugène Bataillon, Montpellier</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sitbon, Marc" sort="Sitbon, Marc" uniqKey="Sitbon M" first="Marc" last="Sitbon">Marc Sitbon</name>
<affiliation wicri:level="3"><nlm:aff id="I4">Institut de Génétique Moléculaire de Montpellier, CNRS UMR 5535, 1919 Route de Mende, Montpellier Cedex 5, F-34293 France</nlm:aff>
<country wicri:rule="zip">France</country>
<wicri:regionArea>Institut de Génétique Moléculaire de Montpellier, CNRS UMR 5535, 1919 Route de Mende, Montpellier Cedex 5, F-34293 France</wicri:regionArea>
<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
<settlement type="city">France</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="I5">Université de Montpellier 1 et 2, Place Eugène Bataillon, Montpellier, 34293 France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Montpellier 1 et 2, Place Eugène Bataillon, Montpellier</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Castelnau, Pierre" sort="Castelnau, Pierre" uniqKey="Castelnau P" first="Pierre" last="Castelnau">Pierre Castelnau</name>
<affiliation wicri:level="4"><nlm:aff id="I1">UMR Inserm U 930, CNRS FRE 2448, Université François Rabelais de Tours, F-37044 Tours, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>UMR Inserm U 930, CNRS FRE 2448, Université François Rabelais de Tours, F-37044 Tours</wicri:regionArea>
<placeName><region type="region" nuts="2">Centre-Val de Loire</region>
<region type="old region" nuts="2">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
<orgName type="university">Université François-Rabelais de Tours</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="I2">Université François Rabelais de Tours, F-37044 Tours, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université François Rabelais de Tours, F-37044 Tours</wicri:regionArea>
<placeName><region type="region" nuts="2">Centre-Val de Loire</region>
<region type="old region" nuts="2">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
<orgName type="university">Université François-Rabelais de Tours</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="I3">Unité de Neuropédiatrie et Centre de compétence Maladies mitochondriales, Pôle Enfant, Hôpital Clocheville, CHRU de Tours, F-37044 Tours, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité de Neuropédiatrie et Centre de compétence Maladies mitochondriales, Pôle Enfant, Hôpital Clocheville, CHRU de Tours, F-37044 Tours</wicri:regionArea>
<placeName><region type="region" nuts="2">Centre-Val de Loire</region>
<region type="old region" nuts="2">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Biomedical Science</title>
<idno type="ISSN">1021-7770</idno>
<idno type="eISSN">1423-0127</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The gibbon ape leukemia virus (GALV), the amphotropic murine leukemia virus (AMLV) and the human T-cell leukemia virus (HTLV) are retroviruses that specifically bind nutrient transporters with their envelope glycoproteins (Env) when entering host cells. Here, we used tagged ligands derived from GALV, AMLV, and HTLV Env to monitor the distribution of their cognate receptors, the inorganic phosphate transporters PiT1 and PiT2, and the glucose transporter GLUT1, respectively, in basal conditions and after acute energy deficiency. For this purpose, we monitored changes in the distribution of PiT1, PiT2 and GLUT1 in the cerebellum, the frontal cortex, the corpus callosum, the striatum and the substantia nigra (SN) of C57/BL6 mice after administration of 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridinium (MPTP), a mitochondrial complex I inhibitor which induces neuronal degeneration in the striato-nigral network.</p>
<p>The PiT1 ligand stained oligodendrocytes in the corpus callosum and showed a reticular pattern in the SN. The PiT2 ligand stained particularly the cerebellar Purkinje cells, while GLUT1 labelling was mainly observed throughout the cortex, basal ganglia and cerebellar gray matter. Interestingly, unlike GLUT1 and PiT2 distributions which did not appear to be modified by MPTP intoxication, PiT1 immunostaining seemed to be more extended in the SN. The plausible reasons for this change following acute energy stress are discussed.</p>
<p>These new ligands therefore constitute new metabolic markers which should help to unravel cellular adaptations to a wide variety of normal and pathologic conditions and to determine the role of specific nutrient transporters in tissue homeostasis.</p>
</div>
</front>
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