Catecholaminergic systems in the medulla oblongata in parkinsonian syndromes: a quantitative immunohistochemical study in Parkinson's disease, progressive supranuclear palsy, and striatonigral degeneration.
Identifieur interne : 000A58 ( Ncbi/Curation ); précédent : 000A57; suivant : 000A59Catecholaminergic systems in the medulla oblongata in parkinsonian syndromes: a quantitative immunohistochemical study in Parkinson's disease, progressive supranuclear palsy, and striatonigral degeneration.
Auteurs : S. Malessa [France] ; E C Hirsch ; P. Cervera ; C. Duyckaerts ; Yves Agid [France]Source :
- Neurology [ 0028-3878 ] ; 1990.
English descriptors
- KwdEn :
- Aged, Catecholamines (metabolism), Corpus Striatum (physiopathology), Female, Humans, Immunohistochemistry, Male, Medulla Oblongata (metabolism), Medulla Oblongata (pathology), Middle Aged, Nerve Degeneration, Neurons (metabolism), Neurons (pathology), Parkinson Disease (metabolism), Parkinson Disease (pathology), Parkinson Disease, Secondary (etiology), Parkinson Disease, Secondary (metabolism), Parkinson Disease, Secondary (pathology), Substantia Nigra (physiopathology), Supranuclear Palsy, Progressive (complications), Supranuclear Palsy, Progressive (metabolism), Supranuclear Palsy, Progressive (pathology), Tyrosine 3-Monooxygenase (metabolism).
- MESH :
- chemical , metabolism : Catecholamines, Tyrosine 3-Monooxygenase.
- complications : Supranuclear Palsy, Progressive.
- etiology : Parkinson Disease, Secondary.
- metabolism : Medulla Oblongata, Neurons, Parkinson Disease, Parkinson Disease, Secondary, Supranuclear Palsy, Progressive.
- pathology : Medulla Oblongata, Neurons, Parkinson Disease, Parkinson Disease, Secondary, Supranuclear Palsy, Progressive.
- physiopathology : Corpus Striatum, Substantia Nigra.
- Aged, Female, Humans, Immunohistochemistry, Male, Middle Aged, Nerve Degeneration.
Abstract
We investigated tyrosine-hydroxylase (TH)-immunoreactive neurons in the medulla oblongata corresponding to the A1 and A2 cell groups in autopsy tissue of patients with Parkinson's disease (PD) (n = 3), progressive supranuclear palsy (PSP) (n = 3), striatonigral degeneration (SND) (n = 2), and in controls (n = 4). The estimated total number of TH-positive neurons in the A1 and the A2 regions was normal in PD and PSP patients. The sparing of medullary catecholaminergic cells in PD and PSP may be related to their minor degree of melanization and the possibility that intermediate compounds associated with the oxidative catabolism of norepinephrine and epinephrine may be less cytotoxic than those generated by degradation of dopamine. Patients with SND showed a marked loss of TH-immunoreactive cells in the A1 and the A2 groups, which may contribute to the impairment of vasomotor control characteristic of the disease.
PubMed: 1978260
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Duyckaerts</name></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author></analytic><series><title level="j">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="1990" type="published">1990</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Catecholamines (metabolism)</term><term>Corpus Striatum (physiopathology)</term><term>Female</term><term>Humans</term><term>Immunohistochemistry</term><term>Male</term><term>Medulla Oblongata (metabolism)</term><term>Medulla Oblongata (pathology)</term><term>Middle Aged</term><term>Nerve Degeneration</term><term>Neurons (metabolism)</term><term>Neurons (pathology)</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease, Secondary (etiology)</term><term>Parkinson Disease, Secondary (metabolism)</term><term>Parkinson Disease, Secondary (pathology)</term><term>Substantia Nigra (physiopathology)</term><term>Supranuclear Palsy, Progressive (complications)</term><term>Supranuclear Palsy, Progressive (metabolism)</term><term>Supranuclear Palsy, Progressive (pathology)</term><term>Tyrosine 3-Monooxygenase (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Catecholamines</term><term>Tyrosine 3-Monooxygenase</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Medulla Oblongata</term><term>Neurons</term><term>Parkinson Disease</term><term>Parkinson Disease, Secondary</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Medulla Oblongata</term><term>Neurons</term><term>Parkinson Disease</term><term>Parkinson Disease, Secondary</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Corpus Striatum</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Immunohistochemistry</term><term>Male</term><term>Middle Aged</term><term>Nerve Degeneration</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated tyrosine-hydroxylase (TH)-immunoreactive neurons in the medulla oblongata corresponding to the A1 and A2 cell groups in autopsy tissue of patients with Parkinson's disease (PD) (n = 3), progressive supranuclear palsy (PSP) (n = 3), striatonigral degeneration (SND) (n = 2), and in controls (n = 4). The estimated total number of TH-positive neurons in the A1 and the A2 regions was normal in PD and PSP patients. The sparing of medullary catecholaminergic cells in PD and PSP may be related to their minor degree of melanization and the possibility that intermediate compounds associated with the oxidative catabolism of norepinephrine and epinephrine may be less cytotoxic than those generated by degradation of dopamine. Patients with SND showed a marked loss of TH-immunoreactive cells in the A1 and the A2 groups, which may contribute to the impairment of vasomotor control characteristic of the disease.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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