Functional reinnervation from remaining DA terminals induced by GDNF lentivirus in a rat model of early Parkinson's disease.
Identifieur interne : 000541 ( Ncbi/Curation ); précédent : 000540; suivant : 000542Functional reinnervation from remaining DA terminals induced by GDNF lentivirus in a rat model of early Parkinson's disease.
Auteurs : Mara Brizard [France] ; Carole Carcenac ; Alexis-Pierre Bemelmans ; Claude Feuerstein ; Jacques Mallet ; Marc SavastaSource :
- Neurobiology of disease [ 0969-9961 ] ; 2006.
English descriptors
- KwdEn :
- Animals, Corpus Striatum (physiopathology), Disease Models, Animal, Dopamine (physiology), Genetic Therapy (methods), Glial Cell Line-Derived Neurotrophic Factor (genetics), Lentivirus (genetics), Male, Movement, Nerve Degeneration (physiopathology), Nerve Degeneration (therapy), Nerve Regeneration, Oxidopamine (toxicity), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Presynaptic Terminals (physiology), Rats, Rats, Sprague-Dawley, Recovery of Function, Sympatholytics (toxicity).
- MESH :
- chemical , genetics : Glial Cell Line-Derived Neurotrophic Factor.
- chemical , physiology : Dopamine.
- genetics : Lentivirus.
- methods : Genetic Therapy.
- physiology : Presynaptic Terminals.
- physiopathology : Corpus Striatum, Nerve Degeneration, Parkinson Disease.
- therapy : Nerve Degeneration, Parkinson Disease.
- chemical , toxicity : Oxidopamine, Sympatholytics.
- Animals, Disease Models, Animal, Male, Movement, Nerve Regeneration, Rats, Rats, Sprague-Dawley, Recovery of Function.
Abstract
Glial cell-line derived neurotrophic factor (GDNF) is a good candidate agent for restoring functional reinnervation and/or neuroprotection of dopamine (DA) nigrostriatal system and thus for the treatment of Parkinson's disease (PD). Viral delivery is currently the most likely in vivo strategy for delivery of the therapeutic protein into the brain for treatment of neurological diseases. However, one of the important unresolved issues for this strategy is the threshold number of DA nigral neurons and/or of striatal DA terminals necessary for optimal benefit from GDNF therapy. In this study, we examined the intrastriatal neurotrophic effects of long-term GDNF delivery using a lentiviral vector in a new rat model of early PD. Lenti-GDNF was injected into the striatum 4 weeks after partial substantia nigra pars compacta 6-hydroxydopamine-induced lesion. Striatal denervation was evaluated by assessing tyrosine hydroxylase-positive DA fiber density and corroborated by testing motor deficit by means of a staircase test. GDNF treatment restored complete striatal DA innervation in the previously denervated area and this was associated with significant behavioral improvements.
DOI: 10.1016/j.nbd.2005.06.015
PubMed: 16084732
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Neurotransmission-Unité Mixte de Recherche, bâtiment CERVI, 83 boulevard de l'Hôpital, 75013 PARIS, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Génétique Moléculaire des Processus Neurodégénératifs et de la Neurotransmission-Unité Mixte de Recherche, bâtiment CERVI, 83 boulevard de l'Hôpital, 75013 PARIS</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">PARIS</settlement></placeName></affiliation></author><author><name sortKey="Carcenac, Carole" sort="Carcenac, Carole" uniqKey="Carcenac C" first="Carole" last="Carcenac">Carole Carcenac</name></author><author><name sortKey="Bemelmans, Alexis Pierre" sort="Bemelmans, Alexis Pierre" uniqKey="Bemelmans A" first="Alexis-Pierre" last="Bemelmans">Alexis-Pierre Bemelmans</name></author><author><name sortKey="Feuerstein, Claude" sort="Feuerstein, Claude" uniqKey="Feuerstein C" first="Claude" last="Feuerstein">Claude Feuerstein</name></author><author><name sortKey="Mallet, Jacques" sort="Mallet, Jacques" uniqKey="Mallet J" first="Jacques" last="Mallet">Jacques Mallet</name></author><author><name sortKey="Savasta, Marc" sort="Savasta, Marc" uniqKey="Savasta M" first="Marc" last="Savasta">Marc Savasta</name></author></analytic><series><title level="j">Neurobiology of disease</title><idno type="ISSN">0969-9961</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Corpus Striatum (physiopathology)</term><term>Disease Models, Animal</term><term>Dopamine (physiology)</term><term>Genetic Therapy (methods)</term><term>Glial Cell Line-Derived Neurotrophic Factor (genetics)</term><term>Lentivirus (genetics)</term><term>Male</term><term>Movement</term><term>Nerve Degeneration (physiopathology)</term><term>Nerve Degeneration (therapy)</term><term>Nerve 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Degeneration</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Nerve Degeneration</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Oxidopamine</term><term>Sympatholytics</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Male</term><term>Movement</term><term>Nerve Regeneration</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Recovery of Function</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Glial cell-line derived neurotrophic factor (GDNF) is a good candidate agent for restoring functional reinnervation and/or neuroprotection of dopamine (DA) nigrostriatal system and thus for the treatment of Parkinson's disease (PD). Viral delivery is currently the most likely in vivo strategy for delivery of the therapeutic protein into the brain for treatment of neurological diseases. However, one of the important unresolved issues for this strategy is the threshold number of DA nigral neurons and/or of striatal DA terminals necessary for optimal benefit from GDNF therapy. In this study, we examined the intrastriatal neurotrophic effects of long-term GDNF delivery using a lentiviral vector in a new rat model of early PD. Lenti-GDNF was injected into the striatum 4 weeks after partial substantia nigra pars compacta 6-hydroxydopamine-induced lesion. Striatal denervation was evaluated by assessing tyrosine hydroxylase-positive DA fiber density and corroborated by testing motor deficit by means of a staircase test. GDNF treatment restored complete striatal DA innervation in the previously denervated area and this was associated with significant behavioral improvements.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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