Neuroinflammatory processes in Parkinson's disease.
Identifieur interne : 000317 ( Ncbi/Curation ); précédent : 000316; suivant : 000318Neuroinflammatory processes in Parkinson's disease.
Auteurs : Stephane Hunot [France] ; E C HirschSource :
- Annals of neurology [ 0364-5134 ] ; 2003.
English descriptors
- KwdEn :
- Antigens, CD (immunology), Cell Death, Corpus Striatum (enzymology), Corpus Striatum (immunology), Corpus Striatum (pathology), Cyclooxygenase 2, Cytokines (immunology), Dopamine (immunology), Dopamine (metabolism), Humans, Interleukins (immunology), Isoenzymes (metabolism), Major Histocompatibility Complex (immunology), Membrane Proteins, Mesencephalon (pathology), Nerve Degeneration (pathology), Neuroglia (immunology), Neuroglia (metabolism), Nitric Oxide Synthase (metabolism), Parkinson Disease (enzymology), Parkinson Disease (immunology), Parkinson Disease (pathology), Prostaglandin-Endoperoxide Synthases (metabolism).
- MESH :
- chemical , immunology : Antigens, CD, Cytokines, Dopamine, Interleukins.
- enzymology : Corpus Striatum, Parkinson Disease.
- immunology : Corpus Striatum, Major Histocompatibility Complex, Neuroglia, Parkinson Disease.
- chemical , metabolism : Dopamine, Isoenzymes, Neuroglia, Nitric Oxide Synthase, Prostaglandin-Endoperoxide Synthases.
- pathology : Corpus Striatum, Mesencephalon, Nerve Degeneration, Parkinson Disease.
- Cell Death, Cyclooxygenase 2, Humans, Membrane Proteins.
Abstract
Parkinson's disease (PD) is a movement disorder characterized by the progressive degeneration of dopaminergic neurons in the midbrain. To date, its cause remains unknown and the mechanism of nerve cell death uncertain. Apart from the massive loss of dopaminergic neurons, PD brains also show a conspicuous glial reaction together with signs of a neuroinflammatory reaction manifested by elevated cytokine levels and upregulation of inflammatory-associated factors such as cyclooxygenase-2 and inducible nitric oxide synthase. Mounting evidence also suggests a possible deleterious effect of these neuroinflammatory processes in experimental models of the disease. We propose that, in PD, neuroinflammation plays a role in the cascade of events leading to nerve cell death, thus propagating the neurodegenerative process. In this review, we summarize and discuss the latest findings regarding neuroinflammatory aspects in PD.
DOI: 10.1002/ana.10481
PubMed: 12666098
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001130
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :001089
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001089
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000317
Links to Exploration step
pubmed:12666098Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neuroinflammatory processes in Parkinson's disease.</title><author><name sortKey="Hunot, Stephane" sort="Hunot, Stephane" uniqKey="Hunot S" first="Stephane" last="Hunot">Stephane Hunot</name><affiliation wicri:level="3"><nlm:affiliation>INSERM U289, Hôpital de la Salpêtrière, Paris, France. hunot@ccr.jussieu.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U289, Hôpital de la Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E C" last="Hirsch">E C Hirsch</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:12666098</idno><idno type="pmid">12666098</idno><idno type="doi">10.1002/ana.10481</idno><idno type="wicri:Area/PubMed/Corpus">001130</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001130</idno><idno type="wicri:Area/PubMed/Curation">001089</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001089</idno><idno type="wicri:Area/PubMed/Checkpoint">001089</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001089</idno><idno type="wicri:Area/Ncbi/Merge">000317</idno><idno type="wicri:Area/Ncbi/Curation">000317</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Neuroinflammatory processes in Parkinson's disease.</title><author><name sortKey="Hunot, Stephane" sort="Hunot, Stephane" uniqKey="Hunot S" first="Stephane" last="Hunot">Stephane Hunot</name><affiliation wicri:level="3"><nlm:affiliation>INSERM U289, Hôpital de la Salpêtrière, Paris, France. hunot@ccr.jussieu.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U289, Hôpital de la Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E C" last="Hirsch">E C Hirsch</name></author></analytic><series><title level="j">Annals of neurology</title><idno type="ISSN">0364-5134</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antigens, CD (immunology)</term><term>Cell Death</term><term>Corpus Striatum (enzymology)</term><term>Corpus Striatum (immunology)</term><term>Corpus Striatum (pathology)</term><term>Cyclooxygenase 2</term><term>Cytokines (immunology)</term><term>Dopamine (immunology)</term><term>Dopamine (metabolism)</term><term>Humans</term><term>Interleukins (immunology)</term><term>Isoenzymes (metabolism)</term><term>Major Histocompatibility Complex (immunology)</term><term>Membrane Proteins</term><term>Mesencephalon (pathology)</term><term>Nerve Degeneration (pathology)</term><term>Neuroglia (immunology)</term><term>Neuroglia (metabolism)</term><term>Nitric Oxide Synthase (metabolism)</term><term>Parkinson Disease (enzymology)</term><term>Parkinson Disease (immunology)</term><term>Parkinson Disease (pathology)</term><term>Prostaglandin-Endoperoxide Synthases (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, CD</term><term>Cytokines</term><term>Dopamine</term><term>Interleukins</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Corpus Striatum</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Corpus Striatum</term><term>Major Histocompatibility Complex</term><term>Neuroglia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term><term>Isoenzymes</term><term>Neuroglia</term><term>Nitric Oxide Synthase</term><term>Prostaglandin-Endoperoxide Synthases</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Corpus Striatum</term><term>Mesencephalon</term><term>Nerve Degeneration</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Death</term><term>Cyclooxygenase 2</term><term>Humans</term><term>Membrane Proteins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is a movement disorder characterized by the progressive degeneration of dopaminergic neurons in the midbrain. To date, its cause remains unknown and the mechanism of nerve cell death uncertain. Apart from the massive loss of dopaminergic neurons, PD brains also show a conspicuous glial reaction together with signs of a neuroinflammatory reaction manifested by elevated cytokine levels and upregulation of inflammatory-associated factors such as cyclooxygenase-2 and inducible nitric oxide synthase. Mounting evidence also suggests a possible deleterious effect of these neuroinflammatory processes in experimental models of the disease. We propose that, in PD, neuroinflammation plays a role in the cascade of events leading to nerve cell death, thus propagating the neurodegenerative process. In this review, we summarize and discuss the latest findings regarding neuroinflammatory aspects in PD.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000317 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000317 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= pubmed:12666098
|texte= Neuroinflammatory processes in Parkinson's disease.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:12666098" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |