Influence of chronic bilateral stimulation of the subthalamic nucleus on cognitive function in Parkinson's disease.
Identifieur interne : 000205 ( Ncbi/Curation ); précédent : 000204; suivant : 000206Influence of chronic bilateral stimulation of the subthalamic nucleus on cognitive function in Parkinson's disease.
Auteurs : K. Dujardin [France] ; L. Defebvre ; P. Krystkowiak ; S. Blond ; A. DestéeSource :
- Journal of neurology [ 0340-5354 ] ; 2001.
English descriptors
- KwdEn :
- Cognition Disorders (etiology), Cognition Disorders (therapy), Electric Stimulation Therapy (adverse effects), Electrodes, Female, Humans, Male, Mental Disorders (drug therapy), Middle Aged, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (psychology), Subthalamic Nucleus (physiology), Treatment Outcome.
- MESH :
- adverse effects : Electric Stimulation Therapy.
- complications : Parkinson Disease.
- drug therapy : Mental Disorders.
- etiology : Cognition Disorders.
- physiology : Subthalamic Nucleus.
- psychology : Parkinson Disease.
- therapy : Cognition Disorders.
- Electrodes, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Treatment Outcome.
Abstract
The clinical efficacy of chronic deep brain stimulation in the treatment of parkinsonian patients with severe levodopa-related motor adverse effects has been repeatedly shown. Bilateral subthalamic nucleus (STN) stimulation has been shown to present an advantage over pallidal stimulation as it induces a higher antiakinetic effect and has positive effects on all parkinsonian symptoms. The morbidity of such surgery is usually considered to be very low. However, few studies have extensively examined the effects of chronic STN stimulation on cognitive function.
PubMed: 11518003
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pubmed:11518003Le document en format XML
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<front><div type="abstract" xml:lang="en">The clinical efficacy of chronic deep brain stimulation in the treatment of parkinsonian patients with severe levodopa-related motor adverse effects has been repeatedly shown. Bilateral subthalamic nucleus (STN) stimulation has been shown to present an advantage over pallidal stimulation as it induces a higher antiakinetic effect and has positive effects on all parkinsonian symptoms. The morbidity of such surgery is usually considered to be very low. However, few studies have extensively examined the effects of chronic STN stimulation on cognitive function.</div>
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