[Central dopaminergic D1 agonists and treatment of Parkinson disease].
Identifieur interne : 001F32 ( Ncbi/Checkpoint ); précédent : 001F31; suivant : 001F33[Central dopaminergic D1 agonists and treatment of Parkinson disease].
Auteurs : C. Soubrouillard [France] ; C. Lombardo ; O. Rascol ; B. Bruguerolle ; O. BlinSource :
- Therapie [ 0040-5957 ]
English descriptors
- KwdEn :
- Animals, Disease Models, Animal, Dopamine Agonists (pharmacokinetics), Dopamine Agonists (therapeutic use), Humans, Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Rats, Receptors, Dopamine D1 (classification), Receptors, Dopamine D1 (drug effects), Receptors, Dopamine D1 (physiology).
- MESH :
- chemical , classification : Receptors, Dopamine D1.
- chemical , drug effects : Receptors, Dopamine D1.
- chemical , pharmacokinetics : Dopamine Agonists.
- chemical , physiology : Receptors, Dopamine D1.
- chemical , therapeutic use : Dopamine Agonists.
- drug therapy : Parkinson Disease.
- physiopathology : Parkinson Disease.
- Animals, Disease Models, Animal, Humans, Rats.
Abstract
Many theories about dopaminergic function in Parkinson's disease are based upon the effects of the D2 receptor. Standard treatments mostly involve dopaminergic D2 agonists. However, the recent development of dopaminergic D1 agonists should help to clarify the role of the D1 receptor in the treatment of Parkinson's disease. The authors review the physiopathological, behavioural and therapeutic data on D1 agonists administered in animal models and in patients.
PubMed: 9734104
Affiliations:
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pubmed:9734104Le document en format XML
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Soubrouillard</name><affiliation wicri:level="3"><nlm:affiliation>Centre de Pharmacologie Clinique et d'Evaluations Thérapeutiques et Laboratoire de Pharmacologie Médicale et Clinique, CHU Timone, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre de Pharmacologie Clinique et d'Evaluations Thérapeutiques et Laboratoire de Pharmacologie Médicale et Clinique, CHU Timone, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Lombardo, C" sort="Lombardo, C" uniqKey="Lombardo C" first="C" last="Lombardo">C. Lombardo</name></author><author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name></author><author><name sortKey="Bruguerolle, B" sort="Bruguerolle, B" uniqKey="Bruguerolle B" first="B" last="Bruguerolle">B. Bruguerolle</name></author><author><name sortKey="Blin, O" sort="Blin, O" uniqKey="Blin O" first="O" last="Blin">O. Blin</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>1997 Nov-Dec</MedlineDate></PubDate></date><idno type="RBID">pubmed:9734104</idno><idno type="pmid">9734104</idno><idno type="wicri:Area/PubMed/Corpus">001510</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001510</idno><idno type="wicri:Area/PubMed/Curation">001469</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001469</idno><idno type="wicri:Area/PubMed/Checkpoint">001469</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001469</idno><idno type="wicri:Area/Ncbi/Merge">001F32</idno><idno type="wicri:Area/Ncbi/Curation">001F32</idno><idno type="wicri:Area/Ncbi/Checkpoint">001F32</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Central dopaminergic D1 agonists and treatment of Parkinson disease].</title><author><name sortKey="Soubrouillard, C" sort="Soubrouillard, C" uniqKey="Soubrouillard C" first="C" last="Soubrouillard">C. Soubrouillard</name><affiliation wicri:level="3"><nlm:affiliation>Centre de Pharmacologie Clinique et d'Evaluations Thérapeutiques et Laboratoire de Pharmacologie Médicale et Clinique, CHU Timone, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre de Pharmacologie Clinique et d'Evaluations Thérapeutiques et Laboratoire de Pharmacologie Médicale et Clinique, CHU Timone, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Lombardo, C" sort="Lombardo, C" uniqKey="Lombardo C" first="C" last="Lombardo">C. Lombardo</name></author><author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name></author><author><name sortKey="Bruguerolle, B" sort="Bruguerolle, B" uniqKey="Bruguerolle B" first="B" last="Bruguerolle">B. Bruguerolle</name></author><author><name sortKey="Blin, O" sort="Blin, O" uniqKey="Blin O" first="O" last="Blin">O. Blin</name></author></analytic><series><title level="j">Therapie</title><idno type="ISSN">0040-5957</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Dopamine Agonists (pharmacokinetics)</term><term>Dopamine Agonists (therapeutic use)</term><term>Humans</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Rats</term><term>Receptors, Dopamine D1 (classification)</term><term>Receptors, Dopamine D1 (drug effects)</term><term>Receptors, Dopamine D1 (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="classification" xml:lang="en"><term>Receptors, Dopamine D1</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Receptors, Dopamine D1</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Dopamine Agonists</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Receptors, Dopamine D1</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Agonists</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Many theories about dopaminergic function in Parkinson's disease are based upon the effects of the D2 receptor. Standard treatments mostly involve dopaminergic D2 agonists. However, the recent development of dopaminergic D1 agonists should help to clarify the role of the D1 receptor in the treatment of Parkinson's disease. The authors review the physiopathological, behavioural and therapeutic data on D1 agonists administered in animal models and in patients.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Marseille</li></settlement></list><tree><noCountry><name sortKey="Blin, O" sort="Blin, O" uniqKey="Blin O" first="O" last="Blin">O. Blin</name><name sortKey="Bruguerolle, B" sort="Bruguerolle, B" uniqKey="Bruguerolle B" first="B" last="Bruguerolle">B. Bruguerolle</name><name sortKey="Lombardo, C" sort="Lombardo, C" uniqKey="Lombardo C" first="C" last="Lombardo">C. Lombardo</name><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name></noCountry><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Soubrouillard, C" sort="Soubrouillard, C" uniqKey="Soubrouillard C" first="C" last="Soubrouillard">C. Soubrouillard</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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