Iron metabolism and Parkinson's disease.
Identifieur interne : 001F19 ( Ncbi/Checkpoint ); précédent : 001F18; suivant : 001F20Iron metabolism and Parkinson's disease.
Auteurs : E C Hirsch [France] ; B A FaucheuxSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1998.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Hydroxyl Radical, Iron, Lactoferrin, Reactive Oxygen Species, Transferrin.
- chemical , physiology : Dopamine.
- pathology : Neurons, Parkinson Disease, Substantia Nigra.
- physiology : Cell Death.
- chemical : Free Radicals, Humans.
Abstract
There are at least three major reasons for thinking that iron participates in the mechanism of nerve cell death in Parkinson's disease (PD): (1) Iron catalyzes the formation of highly toxic hydroxyl radicals through the Fenton reaction. (2) Evidence suggests that oxidative stress participates in the mechanism of nerve cell death in PD. (3) Increased iron concentrations have been observed in the substantia nigra of patients with PD. In this review, we report data suggesting that the vulnerable neurons in PD are particularly sensitive to oxidative stress that may be induced by iron and then discuss the mechanisms by which iron levels may be increased in dopaminergic neurons in PD.
PubMed: 9613717
Affiliations:
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pubmed:9613717Le document en format XML
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<term>Humans</term>
<term>Hydroxyl Radical (metabolism)</term>
<term>Iron (metabolism)</term>
<term>Lactoferrin (metabolism)</term>
<term>Neurons (pathology)</term>
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<front><div type="abstract" xml:lang="en">There are at least three major reasons for thinking that iron participates in the mechanism of nerve cell death in Parkinson's disease (PD): (1) Iron catalyzes the formation of highly toxic hydroxyl radicals through the Fenton reaction. (2) Evidence suggests that oxidative stress participates in the mechanism of nerve cell death in PD. (3) Increased iron concentrations have been observed in the substantia nigra of patients with PD. In this review, we report data suggesting that the vulnerable neurons in PD are particularly sensitive to oxidative stress that may be induced by iron and then discuss the mechanisms by which iron levels may be increased in dopaminergic neurons in PD.</div>
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