[Parkinsonian syndrome and post-encephalitic stereotyped involuntary movements responsive to L-dopa].
Identifieur interne : 001E16 ( Ncbi/Checkpoint ); précédent : 001E15; suivant : 001E17[Parkinsonian syndrome and post-encephalitic stereotyped involuntary movements responsive to L-dopa].
Auteurs : F. Picard [France] ; E. Hirsch ; E. Salmon ; C. Marescaux ; M. CollardSource :
- Revue neurologique [ 0035-3787 ] ; 1996.
English descriptors
- KwdEn :
- Adult, Dopamine Agents (therapeutic use), Encephalitis (complications), Encephalitis, Viral (complications), Encephalitis, Viral (physiopathology), Humans, Levodopa (therapeutic use), Male, Movement Disorders (drug therapy), Movement Disorders (etiology), Movement Disorders (physiopathology), Parkinson Disease, Postencephalitic (drug therapy), Parkinson Disease, Postencephalitic (physiopathology), Time Factors.
- MESH :
- chemical , therapeutic use : Dopamine Agents, Levodopa.
- complications : Encephalitis, Encephalitis, Viral.
- drug therapy : Movement Disorders, Parkinson Disease, Postencephalitic.
- etiology : Movement Disorders.
- physiopathology : Encephalitis, Viral, Movement Disorders, Parkinson Disease, Postencephalitic.
- Adult, Humans, Male, Time Factors.
Abstract
In 1954, when he was five years old, a patient suffered from encephalitis with a prolonged lethargic state. Following this episode, he presented a severe parkinsonian syndrome which was associated, after a few years, with an axial dystonia and stereotyped involuntary movements of the upper limbs. These abnormal movements were particular by their coordinated appearance, their rhythmicity and their relative slowness. Treatment with L-dopa suppressed all akinetic, dystonic and dyskinetic symptoms. At age of 40 years, all the akinetic, dystonic and dyskinetic symptoms reappeared after drug withdrawal. Cerebral computed tomography, magnetic resonance imaging and fluorodeoxyglucose positron emission tomography were normal. Fluorodopa positron emission tomography revealed a significant bilateral reduction of tracer accumulation in the posterior part of both putamen, similar to that observed in patients with idiopathic Parkinson's disease. In this patient, pharmacological tests revealed that effectiveness of L-dopa was abolished by administration of a D2 antagonist, and was fully reproduced by a D2 agonist. Clinical signs, pharmacological data and past-medical history strongly suggested a limited lesion of the zona compacta of substantia nigra induced by viral agression. This complex and progressive extrapyramidal syndrome had strong similarities with the lethargic encephalitis of Von Economo and its late symptoms. Other diseases associating akinesia and dyskinesia or dystonic phenomena, like dopa-sensitive dystonia and juvenile Parkinson's disease, are very unlikely. Thus, the persistance of sporadic forms of Von Economo's encephalitis could be discussed.
PubMed: 8763655
Affiliations:
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pubmed:8763655Le document en format XML
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<front><div type="abstract" xml:lang="en">In 1954, when he was five years old, a patient suffered from encephalitis with a prolonged lethargic state. Following this episode, he presented a severe parkinsonian syndrome which was associated, after a few years, with an axial dystonia and stereotyped involuntary movements of the upper limbs. These abnormal movements were particular by their coordinated appearance, their rhythmicity and their relative slowness. Treatment with L-dopa suppressed all akinetic, dystonic and dyskinetic symptoms. At age of 40 years, all the akinetic, dystonic and dyskinetic symptoms reappeared after drug withdrawal. Cerebral computed tomography, magnetic resonance imaging and fluorodeoxyglucose positron emission tomography were normal. Fluorodopa positron emission tomography revealed a significant bilateral reduction of tracer accumulation in the posterior part of both putamen, similar to that observed in patients with idiopathic Parkinson's disease. In this patient, pharmacological tests revealed that effectiveness of L-dopa was abolished by administration of a D2 antagonist, and was fully reproduced by a D2 agonist. Clinical signs, pharmacological data and past-medical history strongly suggested a limited lesion of the zona compacta of substantia nigra induced by viral agression. This complex and progressive extrapyramidal syndrome had strong similarities with the lethargic encephalitis of Von Economo and its late symptoms. Other diseases associating akinesia and dyskinesia or dystonic phenomena, like dopa-sensitive dystonia and juvenile Parkinson's disease, are very unlikely. Thus, the persistance of sporadic forms of Von Economo's encephalitis could be discussed.</div>
</front>
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