Thalamic stimulation and suppression of parkinsonian tremor. Evidence of a cerebellar deactivation using positron emission tomography.
Identifieur interne : 001D67 ( Ncbi/Checkpoint ); précédent : 001D66; suivant : 001D68Thalamic stimulation and suppression of parkinsonian tremor. Evidence of a cerebellar deactivation using positron emission tomography.
Auteurs : M P Deiber [France] ; P. Pollak ; R. Passingham ; P. Landais ; C. Gervason ; L. Cinotti ; K. Friston ; R. Frackowiak ; F. Mauguière ; A L BenabidSource :
- Brain : a journal of neurology [ 0006-8950 ] ; 1993.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Cerebellum (physiopathology), Cerebrovascular Circulation, Electric Stimulation Therapy, Female, Humans, Male, Middle Aged, Parkinson Disease (diagnostic imaging), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Radionuclide Imaging, Thalamus, Tremor (therapy).
- MESH :
- diagnostic imaging : Parkinson Disease.
- physiopathology : Cerebellum, Parkinson Disease.
- therapy : Parkinson Disease, Tremor.
- Aged, Aged, 80 and over, Cerebrovascular Circulation, Electric Stimulation Therapy, Female, Humans, Male, Middle Aged, Radionuclide Imaging, Thalamus.
Abstract
Parkinsonian tremor can be abolished by chronic high frequency thalamic stimulation of the ventral intermediate nucleus. We have studied six patients with unilateral Parkinson's disease. The patients had an electrode chronically implanted in the ventral intermediate nucleus of the thalamus. We measured changes in cerebral activity by positron emission tomography using an index of regional cerebral blood flow (rCBF). Each patient was scanned in three states: (i) tremor without stimulation (condition A); (ii) tremor with ineffective stimulation (condition B); (iii) tremor abolished by effective stimulation (condition C). The suppression of tremor (C compared with B) was specifically associated with a decrease of rCBF in the cerebellum, whereas the ineffective stimulation (B compared with A) induced a decrease of rCBF in homolateral cerebral cortex. The results give evidence for different contributions from cortex and cerebellum to the generation of parkinsonian tremor and suggest that tremor suppression is mainly associated with a decrease of synaptic activity in the cerebellum.
PubMed: 8453462
Affiliations:
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Passingham</name></author><author><name sortKey="Landais, P" sort="Landais, P" uniqKey="Landais P" first="P" last="Landais">P. Landais</name></author><author><name sortKey="Gervason, C" sort="Gervason, C" uniqKey="Gervason C" first="C" last="Gervason">C. Gervason</name></author><author><name sortKey="Cinotti, L" sort="Cinotti, L" uniqKey="Cinotti L" first="L" last="Cinotti">L. Cinotti</name></author><author><name sortKey="Friston, K" sort="Friston, K" uniqKey="Friston K" first="K" last="Friston">K. Friston</name></author><author><name sortKey="Frackowiak, R" sort="Frackowiak, R" uniqKey="Frackowiak R" first="R" last="Frackowiak">R. Frackowiak</name></author><author><name sortKey="Mauguiere, F" sort="Mauguiere, F" uniqKey="Mauguiere F" first="F" last="Mauguière">F. Mauguière</name></author><author><name sortKey="Benabid, A L" sort="Benabid, A L" uniqKey="Benabid A" first="A L" last="Benabid">A L Benabid</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1993">1993</date><idno type="RBID">pubmed:8453462</idno><idno type="pmid">8453462</idno><idno type="wicri:Area/PubMed/Corpus">001725</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001725</idno><idno type="wicri:Area/PubMed/Curation">001684</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001684</idno><idno type="wicri:Area/PubMed/Checkpoint">001684</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001684</idno><idno type="wicri:Area/Ncbi/Merge">001D67</idno><idno type="wicri:Area/Ncbi/Curation">001D67</idno><idno type="wicri:Area/Ncbi/Checkpoint">001D67</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Thalamic stimulation and suppression of parkinsonian tremor. Evidence of a cerebellar deactivation using positron emission tomography.</title><author><name sortKey="Deiber, M P" sort="Deiber, M P" uniqKey="Deiber M" first="M P" last="Deiber">M P Deiber</name><affiliation wicri:level="3"><nlm:affiliation>CERMEP PET Unit, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CERMEP PET Unit, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P" last="Pollak">P. Pollak</name></author><author><name sortKey="Passingham, R" sort="Passingham, R" uniqKey="Passingham R" first="R" last="Passingham">R. Passingham</name></author><author><name sortKey="Landais, P" sort="Landais, P" uniqKey="Landais P" first="P" last="Landais">P. Landais</name></author><author><name sortKey="Gervason, C" sort="Gervason, C" uniqKey="Gervason C" first="C" last="Gervason">C. Gervason</name></author><author><name sortKey="Cinotti, L" sort="Cinotti, L" uniqKey="Cinotti L" first="L" last="Cinotti">L. Cinotti</name></author><author><name sortKey="Friston, K" sort="Friston, K" uniqKey="Friston K" first="K" last="Friston">K. Friston</name></author><author><name sortKey="Frackowiak, R" sort="Frackowiak, R" uniqKey="Frackowiak R" first="R" last="Frackowiak">R. Frackowiak</name></author><author><name sortKey="Mauguiere, F" sort="Mauguiere, F" uniqKey="Mauguiere F" first="F" last="Mauguière">F. Mauguière</name></author><author><name sortKey="Benabid, A L" sort="Benabid, A L" uniqKey="Benabid A" first="A L" last="Benabid">A L Benabid</name></author></analytic><series><title level="j">Brain : a journal of neurology</title><idno type="ISSN">0006-8950</idno><imprint><date when="1993" type="published">1993</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cerebellum (physiopathology)</term><term>Cerebrovascular Circulation</term><term>Electric Stimulation Therapy</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (diagnostic imaging)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Radionuclide Imaging</term><term>Thalamus</term><term>Tremor (therapy)</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebellum</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term><term>Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cerebrovascular Circulation</term><term>Electric Stimulation Therapy</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Radionuclide Imaging</term><term>Thalamus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinsonian tremor can be abolished by chronic high frequency thalamic stimulation of the ventral intermediate nucleus. We have studied six patients with unilateral Parkinson's disease. The patients had an electrode chronically implanted in the ventral intermediate nucleus of the thalamus. We measured changes in cerebral activity by positron emission tomography using an index of regional cerebral blood flow (rCBF). Each patient was scanned in three states: (i) tremor without stimulation (condition A); (ii) tremor with ineffective stimulation (condition B); (iii) tremor abolished by effective stimulation (condition C). The suppression of tremor (C compared with B) was specifically associated with a decrease of rCBF in the cerebellum, whereas the ineffective stimulation (B compared with A) induced a decrease of rCBF in homolateral cerebral cortex. The results give evidence for different contributions from cortex and cerebellum to the generation of parkinsonian tremor and suggest that tremor suppression is mainly associated with a decrease of synaptic activity in the cerebellum.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Lyon</li></settlement></list><tree><noCountry><name sortKey="Benabid, A L" sort="Benabid, A L" uniqKey="Benabid A" first="A L" last="Benabid">A L Benabid</name><name sortKey="Cinotti, L" sort="Cinotti, L" uniqKey="Cinotti L" first="L" last="Cinotti">L. Cinotti</name><name sortKey="Frackowiak, R" sort="Frackowiak, R" uniqKey="Frackowiak R" first="R" last="Frackowiak">R. Frackowiak</name><name sortKey="Friston, K" sort="Friston, K" uniqKey="Friston K" first="K" last="Friston">K. Friston</name><name sortKey="Gervason, C" sort="Gervason, C" uniqKey="Gervason C" first="C" last="Gervason">C. Gervason</name><name sortKey="Landais, P" sort="Landais, P" uniqKey="Landais P" first="P" last="Landais">P. Landais</name><name sortKey="Mauguiere, F" sort="Mauguiere, F" uniqKey="Mauguiere F" first="F" last="Mauguière">F. Mauguière</name><name sortKey="Passingham, R" sort="Passingham, R" uniqKey="Passingham R" first="R" last="Passingham">R. Passingham</name><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P" last="Pollak">P. Pollak</name></noCountry><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Deiber, M P" sort="Deiber, M P" uniqKey="Deiber M" first="M P" last="Deiber">M P Deiber</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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