Apomorphine increases blood glucose concentrations in Parkinson's disease.
Identifieur interne : 001D28 ( Ncbi/Checkpoint ); précédent : 001D27; suivant : 001D29Apomorphine increases blood glucose concentrations in Parkinson's disease.
Auteurs : F. Tison [France] ; N. Fouillet ; P. HenrySource :
- Clinical neuropharmacology [ 0362-5664 ] ; 1994.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Apomorphine.
- chemical , metabolism : Blood Glucose.
- chemical , therapeutic use : Apomorphine, Levodopa.
- blood : Parkinson Disease.
- drug therapy : Parkinson Disease, Parkinson Disease, Secondary.
- Aged, Humans.
Abstract
Data from studies indicate that blood glucose levels may be influenced by stimulation of central D1 and D2 dopamine receptors. This is modulated by central dopamine receptor status. We studied apomorphine-induced increase in blood glucose levels in Parkinson's disease compared with those in Parkinsonian syndromes unresponsive to dopaminergic drugs. Results indicate that apomorphine-induced blood glucose level increases are significant only in Parkinson's disease. As in the animal, this could possibly be explained by central dopamine receptor status.
PubMed: 8149364
Affiliations:
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pubmed:8149364Le document en format XML
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Tison</name><affiliation wicri:level="3"><nlm:affiliation>Service de Neurologie, Hôpital Pellegrin, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, Hôpital Pellegrin, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Fouillet, N" sort="Fouillet, N" uniqKey="Fouillet N" first="N" last="Fouillet">N. Fouillet</name></author><author><name sortKey="Henry, P" sort="Henry, P" uniqKey="Henry P" first="P" last="Henry">P. Henry</name></author></analytic><series><title level="j">Clinical neuropharmacology</title><idno type="ISSN">0362-5664</idno><imprint><date when="1994" type="published">1994</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Apomorphine (adverse effects)</term><term>Apomorphine (therapeutic use)</term><term>Blood Glucose (metabolism)</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Parkinson Disease (blood)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease, Secondary (drug therapy)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Apomorphine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Blood Glucose</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Apomorphine</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Data from studies indicate that blood glucose levels may be influenced by stimulation of central D1 and D2 dopamine receptors. This is modulated by central dopamine receptor status. We studied apomorphine-induced increase in blood glucose levels in Parkinson's disease compared with those in Parkinsonian syndromes unresponsive to dopaminergic drugs. Results indicate that apomorphine-induced blood glucose level increases are significant only in Parkinson's disease. As in the animal, this could possibly be explained by central dopamine receptor status.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Aquitaine</li><li>Nouvelle-Aquitaine</li></region><settlement><li>Bordeaux</li></settlement></list><tree><noCountry><name sortKey="Fouillet, N" sort="Fouillet, N" uniqKey="Fouillet N" first="N" last="Fouillet">N. Fouillet</name><name sortKey="Henry, P" sort="Henry, P" uniqKey="Henry P" first="P" last="Henry">P. Henry</name></noCountry><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Tison, F" sort="Tison, F" uniqKey="Tison F" first="F" last="Tison">F. 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