Contribution of cholesterol and oxysterols to the pathophysiology of Parkinson's disease.
Identifieur interne : 001B52 ( Ncbi/Checkpoint ); précédent : 001B51; suivant : 001B53Contribution of cholesterol and oxysterols to the pathophysiology of Parkinson's disease.
Auteurs : Margaux Doria [France] ; Lucie Maugest [France] ; Thibault Moreau [France] ; Gérard Lizard [France] ; Anne Vejux [France]Source :
- Free radical biology & medicine [ 1873-4596 ] ; 2016.
Abstract
Neurodegenerative diseases are a major public health issue worldwide. Some countries, including France, have engaged in research into the causes of Parkinson's disease, Alzheimer's disease, and multiple sclerosis and the management of these patients. It should lead to a better understanding of the mechanisms leading to these diseases including the possible involvement of lipids in their pathogenesis. Parkinson's disease is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra and the accumulation of α-synuclein (Lewy bodies). Several in vivo studies have shown a relationship between the lipid profile [cholesterol, oxidized cholesterol products (oxysterols) formed either enzymatically or by auto-oxidation], the use of drugs regulating cholesterol levels, and the development of Parkinson's disease. Several oxysterols are present in the brain and could play a role in the development of this disease, particularly in the accumulation of α-synuclein, and through various side effects, such as oxidation, inflammation, and cell death. Consequently, in Parkinson's disease, some oxysterols could contribute to the pathophysiology of the disease and constitute potential biomarkers or therapeutic targets.
DOI: 10.1016/j.freeradbiomed.2016.10.008
PubMed: 27836779
Affiliations:
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Department of Neurology, University Hospital/University of Bourgogne Franche-Comté, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Team 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' EA 7270, Université de Bourgogne Franche-Comté, INSERM, Dijon, France; Department of Neurology, University Hospital/University of Bourgogne Franche-Comté, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Moreau, Thibault" sort="Moreau, Thibault" uniqKey="Moreau T" first="Thibault" last="Moreau">Thibault Moreau</name><affiliation wicri:level="3"><nlm:affiliation>Team 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' EA 7270, Université de Bourgogne Franche-Comté, INSERM, Dijon, France; Department of Neurology, University Hospital/University of Bourgogne Franche-Comté, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Team 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' EA 7270, Université de Bourgogne Franche-Comté, INSERM, Dijon, France; 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Electronic address: anne.vejux@u-bourgogne.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Team 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' EA 7270, Université de Bourgogne Franche-Comté, INSERM, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author></analytic><series><title level="j">Free radical biology & medicine</title><idno type="eISSN">1873-4596</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Neurodegenerative diseases are a major public health issue worldwide. Some countries, including France, have engaged in research into the causes of Parkinson's disease, Alzheimer's disease, and multiple sclerosis and the management of these patients. It should lead to a better understanding of the mechanisms leading to these diseases including the possible involvement of lipids in their pathogenesis. Parkinson's disease is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra and the accumulation of α-synuclein (Lewy bodies). Several in vivo studies have shown a relationship between the lipid profile [cholesterol, oxidized cholesterol products (oxysterols) formed either enzymatically or by auto-oxidation], the use of drugs regulating cholesterol levels, and the development of Parkinson's disease. Several oxysterols are present in the brain and could play a role in the development of this disease, particularly in the accumulation of α-synuclein, and through various side effects, such as oxidation, inflammation, and cell death. Consequently, in Parkinson's disease, some oxysterols could contribute to the pathophysiology of the disease and constitute potential biomarkers or therapeutic targets.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Bourgogne</li><li>Bourgogne-Franche-Comté</li></region><settlement><li>Dijon</li></settlement></list><tree><country name="France"><region name="Bourgogne-Franche-Comté"><name sortKey="Doria, Margaux" sort="Doria, Margaux" uniqKey="Doria M" first="Margaux" last="Doria">Margaux Doria</name></region><name sortKey="Lizard, Gerard" sort="Lizard, Gerard" uniqKey="Lizard G" first="Gérard" last="Lizard">Gérard Lizard</name><name sortKey="Maugest, Lucie" sort="Maugest, Lucie" uniqKey="Maugest L" first="Lucie" last="Maugest">Lucie Maugest</name><name sortKey="Moreau, Thibault" sort="Moreau, Thibault" uniqKey="Moreau T" first="Thibault" last="Moreau">Thibault Moreau</name><name sortKey="Vejux, Anne" sort="Vejux, Anne" uniqKey="Vejux A" first="Anne" last="Vejux">Anne Vejux</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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