Anesthesia reduces discharge rates in the human pallidum without changing the discharge rate ratio between pallidal segments.
Identifieur interne : 001B34 ( Ncbi/Checkpoint ); précédent : 001B33; suivant : 001B35Anesthesia reduces discharge rates in the human pallidum without changing the discharge rate ratio between pallidal segments.
Auteurs : Anna Castrioto [France] ; Odeya Marmor [Israël] ; Marc Deffains [Israël] ; Dafna Willner [Israël] ; Eduard Linetsky [Israël] ; Hagai Bergman [Israël] ; Zvi Israel [Israël] ; Renana Eitan [Israël] ; David Arkadir [Israël]Source :
- The European journal of neuroscience [ 1460-9568 ] ; 2016.
Abstract
Classical rate models of basal ganglia circuitry associate discharge rate of the globus pallidus external and internal segments (GPe, GPi respectively) solely with dopaminergic state and predict an inverse ratio between the discharge rates of the two pallidal segments. In contrast, the effects of other rate modulators such as general anesthesia (GA) on this ratio have been ignored. To respond to this need, we recorded the neuronal activity in the GPe and GPi in awake and anesthetized human patients with dystonia (57 and 53 trajectories respectively) and in awake patients with Parkinson's disease (PD, 16 trajectories) undergoing deep brain stimulation procedures. This triad enabled us to dissociate pallidal discharge ratio from general discharge modulation. An automatic offline spike detection and isolation quality system was used to select 1560 highly isolated units for analysis. The mean discharge rate in the GPi of awake PD patients was dramatically higher than in awake dystonia patients although the firing rate in the GPe was similar. Firing rates in dystonic patients under anesthesia were lower in both nuclei. Surprisingly, in all three groups, GPe firing rates were correlated with firing rates in the ipsilateral GPi. Thus, the firing rate ratio of ipsilateral GPi/GPe pairs was similar in awake and anesthetized patients with dystonia and significantly higher in PD. We suggest that pallidal activity is modulated by at least two independent processes: dopaminergic state which changes the GPi/GPe firing rate ratio, and anesthesia which modulates firing rates in both pallidal nuclei without changing the ratio between their firing rates.
DOI: 10.1111/ejn.13417
PubMed: 27717186
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discharge rates in the human pallidum without changing the discharge rate ratio between pallidal segments.</title><author><name sortKey="Castrioto, Anna" sort="Castrioto, Anna" uniqKey="Castrioto A" first="Anna" last="Castrioto">Anna Castrioto</name><affiliation wicri:level="3"><nlm:affiliation>Grenoble Institut des Neurosciences (GIN), University of Grenoble Alpes, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Grenoble Institut des Neurosciences (GIN), University of Grenoble Alpes, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Marmor, Odeya" sort="Marmor, Odeya" uniqKey="Marmor O" first="Odeya" last="Marmor">Odeya Marmor</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Neurobiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Medical Neurobiology, Hadassah-Hebrew University Medical Center, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Deffains, Marc" sort="Deffains, Marc" uniqKey="Deffains M" first="Marc" last="Deffains">Marc Deffains</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Neurobiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Medical Neurobiology, Hadassah-Hebrew University Medical Center, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Willner, Dafna" sort="Willner, Dafna" uniqKey="Willner D" first="Dafna" last="Willner">Dafna Willner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Anesthesiology, Hadassah-Hebrew University Medical Center, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Linetsky, Eduard" sort="Linetsky, Eduard" uniqKey="Linetsky E" first="Eduard" last="Linetsky">Eduard Linetsky</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem, 91120, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem, 91120</wicri:regionArea><wicri:noRegion>91120</wicri:noRegion></affiliation></author><author><name sortKey="Bergman, Hagai" sort="Bergman, Hagai" uniqKey="Bergman H" first="Hagai" last="Bergman">Hagai Bergman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Neurobiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Medical Neurobiology, Hadassah-Hebrew University Medical Center, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Israel, Zvi" sort="Israel, Zvi" uniqKey="Israel Z" first="Zvi" last="Israel">Zvi Israel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurosurgery, Center for Functional and Restorative Neurosurgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Neurosurgery, Center for Functional and Restorative Neurosurgery, Hadassah-Hebrew University Medical Center, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Eitan, Renana" sort="Eitan, Renana" uniqKey="Eitan R" first="Renana" last="Eitan">Renana Eitan</name><affiliation wicri:level="1"><nlm:affiliation>Edmond and Lily Safra Centre for Brain Research, The Hebrew University, Jerusalem, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Edmond and Lily Safra Centre for Brain Research, The Hebrew University, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Arkadir, David" sort="Arkadir, David" uniqKey="Arkadir D" first="David" last="Arkadir">David Arkadir</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem, 91120, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem, 91120</wicri:regionArea><wicri:noRegion>91120</wicri:noRegion></affiliation></author></analytic><series><title level="j">The European journal of neuroscience</title><idno type="eISSN">1460-9568</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Classical rate models of basal ganglia circuitry associate discharge rate of the globus pallidus external and internal segments (GPe, GPi respectively) solely with dopaminergic state and predict an inverse ratio between the discharge rates of the two pallidal segments. In contrast, the effects of other rate modulators such as general anesthesia (GA) on this ratio have been ignored. To respond to this need, we recorded the neuronal activity in the GPe and GPi in awake and anesthetized human patients with dystonia (57 and 53 trajectories respectively) and in awake patients with Parkinson's disease (PD, 16 trajectories) undergoing deep brain stimulation procedures. This triad enabled us to dissociate pallidal discharge ratio from general discharge modulation. An automatic offline spike detection and isolation quality system was used to select 1560 highly isolated units for analysis. The mean discharge rate in the GPi of awake PD patients was dramatically higher than in awake dystonia patients although the firing rate in the GPe was similar. Firing rates in dystonic patients under anesthesia were lower in both nuclei. Surprisingly, in all three groups, GPe firing rates were correlated with firing rates in the ipsilateral GPi. Thus, the firing rate ratio of ipsilateral GPi/GPe pairs was similar in awake and anesthetized patients with dystonia and significantly higher in PD. We suggest that pallidal activity is modulated by at least two independent processes: dopaminergic state which changes the GPi/GPe firing rate ratio, and anesthesia which modulates firing rates in both pallidal nuclei without changing the ratio between their firing rates.</div></front></TEI><affiliations><list><country><li>France</li><li>Israël</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Grenoble</li></settlement></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Castrioto, Anna" sort="Castrioto, Anna" uniqKey="Castrioto A" first="Anna" last="Castrioto">Anna Castrioto</name></region></country><country name="Israël"><noRegion><name sortKey="Marmor, Odeya" sort="Marmor, Odeya" uniqKey="Marmor O" first="Odeya" last="Marmor">Odeya Marmor</name></noRegion><name sortKey="Arkadir, David" sort="Arkadir, David" uniqKey="Arkadir D" first="David" last="Arkadir">David Arkadir</name><name sortKey="Bergman, Hagai" sort="Bergman, Hagai" uniqKey="Bergman H" first="Hagai" last="Bergman">Hagai Bergman</name><name sortKey="Deffains, Marc" sort="Deffains, Marc" uniqKey="Deffains M" first="Marc" last="Deffains">Marc Deffains</name><name sortKey="Eitan, Renana" sort="Eitan, Renana" uniqKey="Eitan R" first="Renana" last="Eitan">Renana Eitan</name><name sortKey="Israel, Zvi" sort="Israel, Zvi" uniqKey="Israel Z" first="Zvi" last="Israel">Zvi Israel</name><name sortKey="Linetsky, Eduard" sort="Linetsky, Eduard" uniqKey="Linetsky E" first="Eduard" last="Linetsky">Eduard Linetsky</name><name sortKey="Willner, Dafna" sort="Willner, Dafna" uniqKey="Willner D" first="Dafna" last="Willner">Dafna Willner</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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