Detection and interpretation of shared genetic influences on 42 human traits
Identifieur interne : 001A21 ( Ncbi/Checkpoint ); précédent : 001A20; suivant : 001A22Detection and interpretation of shared genetic influences on 42 human traits
Auteurs : Joseph K. Pickrell [États-Unis] ; Tomaz Berisa [États-Unis] ; Jimmy Z. Liu [États-Unis] ; Laure Segurel [France] ; Joyce Y. Tung [États-Unis] ; David Hinds [États-Unis]Source :
- Nature genetics [ 1061-4036 ] ; 2016.
Abstract
We performed a scan for genetic variants associated with multiple phenotypes by comparing large genome-wide association studies (GWAS) of 42 traits or diseases. We identified 341 loci (at an FDR of 10%) associated with multiple traits. Several loci are associated with a large number of phenotypes; for example, a nonsynonymous variant in the zinc transporter SLC39A8 influences seven of these traits, including risk of schizophrenia (rs13107325: log-odds ratio = 0.15, P = 2 × 10−12) and Parkinson's disease (log-odds ratio = −0.15, P = 1.6 × 10−7), among others. Second, we used these loci to identify traits that share multiple genetic causes in common. For example, variants that increase risk of schizophrenia also tend to increase risk of inflammatory bowel disease. Finally, we developed a method to identify pairs of traits that show evidence of a causal relationship. For example, we show evidence that increased BMI causally increases triglyceride levels.
Url:
DOI: 10.1038/ng.3570
PubMed: 27182965
PubMed Central: 5207801
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000885
- to stream Pmc, to step Curation: 000882
- to stream Pmc, to step Checkpoint: 000096
- to stream PubMed, to step Corpus: 000124
- to stream PubMed, to step Curation: 000124
- to stream PubMed, to step Checkpoint: 000124
- to stream Ncbi, to step Merge: 001A21
- to stream Ncbi, to step Curation: 001A21
Links to Exploration step
PMC:5207801Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Detection and interpretation of shared genetic influences on 42 human traits</title><author><name sortKey="Pickrell, Joseph K" sort="Pickrell, Joseph K" uniqKey="Pickrell J" first="Joseph K." last="Pickrell">Joseph K. Pickrell</name><affiliation wicri:level="2"><nlm:aff id="A1"> New York Genome Center, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> New York Genome Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2"> Department of Biological Sciences, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Biological Sciences, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Berisa, Tomaz" sort="Berisa, Tomaz" uniqKey="Berisa T" first="Tomaz" last="Berisa">Tomaz Berisa</name><affiliation wicri:level="2"><nlm:aff id="A1"> New York Genome Center, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> New York Genome Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Liu, Jimmy Z" sort="Liu, Jimmy Z" uniqKey="Liu J" first="Jimmy Z." last="Liu">Jimmy Z. Liu</name><affiliation wicri:level="2"><nlm:aff id="A1"> New York Genome Center, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> New York Genome Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Segurel, Laure" sort="Segurel, Laure" uniqKey="Segurel L" first="Laure" last="Segurel">Laure Segurel</name><affiliation wicri:level="3"><nlm:aff id="A3"> UMR7206 Eco-anthropologie et ethnobiologie, CNRS-MNHN-Paris 7, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> UMR7206 Eco-anthropologie et ethnobiologie, CNRS-MNHN-Paris 7, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Tung, Joyce Y" sort="Tung, Joyce Y" uniqKey="Tung J" first="Joyce Y." last="Tung">Joyce Y. Tung</name><affiliation wicri:level="2"><nlm:aff id="A4"> 23andMe, Inc., Mountain View, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> 23andMe, Inc., Mountain View, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hinds, David" sort="Hinds, David" uniqKey="Hinds D" first="David" last="Hinds">David Hinds</name><affiliation wicri:level="2"><nlm:aff id="A4"> 23andMe, Inc., Mountain View, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> 23andMe, Inc., Mountain View, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27182965</idno><idno type="pmc">5207801</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207801</idno><idno type="RBID">PMC:5207801</idno><idno type="doi">10.1038/ng.3570</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000885</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000885</idno><idno type="wicri:Area/Pmc/Curation">000882</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000882</idno><idno type="wicri:Area/Pmc/Checkpoint">000096</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000096</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000124</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000124</idno><idno type="wicri:Area/PubMed/Curation">000124</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000124</idno><idno type="wicri:Area/PubMed/Checkpoint">000124</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000124</idno><idno type="wicri:Area/Ncbi/Merge">001A21</idno><idno type="wicri:Area/Ncbi/Curation">001A21</idno><idno type="wicri:Area/Ncbi/Checkpoint">001A21</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Detection and interpretation of shared genetic influences on 42 human traits</title><author><name sortKey="Pickrell, Joseph K" sort="Pickrell, Joseph K" uniqKey="Pickrell J" first="Joseph K." last="Pickrell">Joseph K. Pickrell</name><affiliation wicri:level="2"><nlm:aff id="A1"> New York Genome Center, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> New York Genome Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2"> Department of Biological Sciences, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Biological Sciences, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Berisa, Tomaz" sort="Berisa, Tomaz" uniqKey="Berisa T" first="Tomaz" last="Berisa">Tomaz Berisa</name><affiliation wicri:level="2"><nlm:aff id="A1"> New York Genome Center, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> New York Genome Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Liu, Jimmy Z" sort="Liu, Jimmy Z" uniqKey="Liu J" first="Jimmy Z." last="Liu">Jimmy Z. Liu</name><affiliation wicri:level="2"><nlm:aff id="A1"> New York Genome Center, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> New York Genome Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Segurel, Laure" sort="Segurel, Laure" uniqKey="Segurel L" first="Laure" last="Segurel">Laure Segurel</name><affiliation wicri:level="3"><nlm:aff id="A3"> UMR7206 Eco-anthropologie et ethnobiologie, CNRS-MNHN-Paris 7, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> UMR7206 Eco-anthropologie et ethnobiologie, CNRS-MNHN-Paris 7, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Tung, Joyce Y" sort="Tung, Joyce Y" uniqKey="Tung J" first="Joyce Y." last="Tung">Joyce Y. Tung</name><affiliation wicri:level="2"><nlm:aff id="A4"> 23andMe, Inc., Mountain View, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> 23andMe, Inc., Mountain View, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hinds, David" sort="Hinds, David" uniqKey="Hinds D" first="David" last="Hinds">David Hinds</name><affiliation wicri:level="2"><nlm:aff id="A4"> 23andMe, Inc., Mountain View, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> 23andMe, Inc., Mountain View, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">We performed a scan for genetic variants associated with multiple phenotypes by comparing large genome-wide association studies (GWAS) of 42 traits or diseases. We identified 341 loci (at an FDR of 10%) associated with multiple traits. Several loci are associated with a large number of phenotypes; for example, a nonsynonymous variant in the zinc transporter SLC39A8 influences seven of these traits, including risk of schizophrenia (rs13107325: log-odds ratio = 0.15, P = 2 × 10<sup>−12</sup>) and Parkinson's disease (log-odds ratio = −0.15, P = 1.6 × 10<sup>−7</sup>), among others. Second, we used these loci to identify traits that share multiple genetic causes in common. For example, variants that increase risk of schizophrenia also tend to increase risk of inflammatory bowel disease. Finally, we developed a method to identify pairs of traits that show evidence of a causal relationship. For example, we show evidence that increased BMI causally increases triglyceride levels.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Stearns, Fw" uniqKey="Stearns F">FW Stearns</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paaby, Ab" uniqKey="Paaby A">AB Paaby</name></author><author><name sortKey="Rockman, Mv" uniqKey="Rockman M">MV Rockman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Solovieff, N" uniqKey="Solovieff N">N Solovieff</name></author><author><name sortKey="Cotsapas, C" uniqKey="Cotsapas C">C Cotsapas</name></author><author><name sortKey="Lee, Ph" uniqKey="Lee P">PH Lee</name></author><author><name sortKey="Purcell, Sm" uniqKey="Purcell S">SM Purcell</name></author><author><name sortKey="Smoller, Jw" uniqKey="Smoller J">JW Smoller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chill N, M" uniqKey="Chill N M">M Chillón</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muller, C" uniqKey="Muller C">C Müller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steinberg, D" uniqKey="Steinberg D">D Steinberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pearl, J" uniqKey="Pearl J">J Pearl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steinberg, D" uniqKey="Steinberg D">D Steinberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Visscher, Pm" uniqKey="Visscher P">PM Visscher</name></author><author><name sortKey="Brown, Ma" uniqKey="Brown M">MA Brown</name></author><author><name sortKey="Mccarthy, Mi" uniqKey="Mccarthy M">MI McCarthy</name></author><author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cotsapas, C" uniqKey="Cotsapas C">C Cotsapas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andreassen, Oa" uniqKey="Andreassen O">OA Andreassen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andreassen, Oa" uniqKey="Andreassen O">OA Andreassen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elliott, Ks" uniqKey="Elliott K">KS Elliott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sivakumaran, S" uniqKey="Sivakumaran S">S Sivakumaran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stefansson, H" uniqKey="Stefansson H">H Stefansson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Styrkarsdottir, U" uniqKey="Styrkarsdottir U">U Styrkarsdottir</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Estrada, K" uniqKey="Estrada K">K Estrada</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moltke, I" uniqKey="Moltke I">I Moltke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pendergrass, Sa" uniqKey="Pendergrass S">SA Pendergrass</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Katan, Mb" uniqKey="Katan M">MB Katan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davey Smith, G" uniqKey="Davey Smith G">G Davey Smith</name></author><author><name sortKey="Ebrahim, S" uniqKey="Ebrahim S">S Ebrahim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davey Smith, G" uniqKey="Davey Smith G">G Davey Smith</name></author><author><name sortKey="Hemani, G" uniqKey="Hemani G">G Hemani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Voight, Bf" uniqKey="Voight B">BF Voight</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lim, Et" uniqKey="Lim E">ET Lim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Panoutsopoulou, K" uniqKey="Panoutsopoulou K">K Panoutsopoulou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holmes, Mv" uniqKey="Holmes M">MV Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Silva, Nmg" uniqKey="De Silva N">NMG De Silva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Granell, R" uniqKey="Granell R">R Granell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pichler, I" uniqKey="Pichler I">I Pichler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parkes, M" uniqKey="Parkes M">M Parkes</name></author><author><name sortKey="Cortes, A" uniqKey="Cortes A">A Cortes</name></author><author><name sortKey="Van Heel, Da" uniqKey="Van Heel D">DA van Heel</name></author><author><name sortKey="Brown, Ma" uniqKey="Brown M">MA Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fortune, Md" uniqKey="Fortune M">MD Fortune</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Denny, Jc" uniqKey="Denny J">JC Denny</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abecasis, G" uniqKey="Abecasis G">G Abecasis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pasaniuc, B" uniqKey="Pasaniuc B">B Pasaniuc</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pickrell, Jk" uniqKey="Pickrell J">JK Pickrell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giambartolomei, C" uniqKey="Giambartolomei C">C Giambartolomei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bulik Sullivan, B" uniqKey="Bulik Sullivan B">B Bulik-Sullivan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name></author><author><name sortKey="Lee, Sh" uniqKey="Lee S">SH Lee</name></author><author><name sortKey="Goddard, Me" uniqKey="Goddard M">ME Goddard</name></author><author><name sortKey="Visscher, Pm" uniqKey="Visscher P">PM Visscher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loh, P R" uniqKey="Loh P">P-R Loh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Flint, J" uniqKey="Flint J">J Flint</name></author><author><name sortKey="Mackay, Tfc" uniqKey="Mackay T">TFC Mackay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perry, Jrb" uniqKey="Perry J">JRB Perry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Richard Miceli, C" uniqKey="Richard Miceli C">C Richard-Miceli</name></author><author><name sortKey="Criswell, La" uniqKey="Criswell L">LA Criswell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schunkert, H" uniqKey="Schunkert H">H Schunkert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wessel, J" uniqKey="Wessel J">J Wessel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Franchini, M" uniqKey="Franchini M">M Franchini</name></author><author><name sortKey="Lippi, G" uniqKey="Lippi G">G Lippi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kominato, Y" uniqKey="Kominato Y">Y Kominato</name></author><author><name sortKey="Tsuchiya, T" uniqKey="Tsuchiya T">T Tsuchiya</name></author><author><name sortKey="Hata, N" uniqKey="Hata N">N Hata</name></author><author><name sortKey="Takizawa, H" uniqKey="Takizawa H">H Takizawa</name></author><author><name sortKey="Yamamoto, F" uniqKey="Yamamoto F">F Yamamoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smemo, S" uniqKey="Smemo S">S Smemo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Claussnitzer, M" uniqKey="Claussnitzer M">M Claussnitzer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jeck, Wr" uniqKey="Jeck W">WR Jeck</name></author><author><name sortKey="Siebold, Ap" uniqKey="Siebold A">AP Siebold</name></author><author><name sortKey="Sharpless, Ne" uniqKey="Sharpless N">NE Sharpless</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elks, Ce" uniqKey="Elks C">CE Elks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, R" uniqKey="Li R">R Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Richards, Jb" uniqKey="Richards J">JB Richards</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamilton, Jb" uniqKey="Hamilton J">JB Hamilton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eaton, Ww" uniqKey="Eaton W">WW Eaton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eaton, W" uniqKey="Eaton W">W Eaton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Benros, Me" uniqKey="Benros M">ME Benros</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Shai, I" uniqKey="Shai I">I Shai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wurtz, P" uniqKey="Wurtz P">P Würtz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Freathy, Rm" uniqKey="Freathy R">RM Freathy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rivkees, Sa" uniqKey="Rivkees S">SA Rivkees</name></author><author><name sortKey="Bode, Hh" uniqKey="Bode H">HH Bode</name></author><author><name sortKey="Crawford, Jd" uniqKey="Crawford J">JD Crawford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Sh" uniqKey="Lee S">SH Lee</name></author><author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name></author><author><name sortKey="Goddard, Me" uniqKey="Goddard M">ME Goddard</name></author><author><name sortKey="Visscher, Pm" uniqKey="Visscher P">PM Visscher</name></author><author><name sortKey="Wray, Nr" uniqKey="Wray N">NR Wray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Visscher, Pm" uniqKey="Visscher P">PM Visscher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ueland, Pm" uniqKey="Ueland P">PM Ueland</name></author><author><name sortKey="Hustad, S" uniqKey="Hustad S">S Hustad</name></author><author><name sortKey="Schneede, J" uniqKey="Schneede J">J Schneede</name></author><author><name sortKey="Refsum, H" uniqKey="Refsum H">H Refsum</name></author><author><name sortKey="Vollset, Se" uniqKey="Vollset S">SE Vollset</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, G" uniqKey="Zhang G">G Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gianola, D" uniqKey="Gianola D">D Gianola</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wood, Ar" uniqKey="Wood A">AR Wood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Locke, Ae" uniqKey="Locke A">AE Locke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Evans, Dm" uniqKey="Evans D">DM Evans</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lambert, Jc" uniqKey="Lambert J">JC Lambert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Okbay, A" uniqKey="Okbay A">A Okbay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shungin, D" uniqKey="Shungin D">D Shungin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jostins, L" uniqKey="Jostins L">L Jostins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Okada, Y" uniqKey="Okada Y">Y Okada</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morris, Ap" uniqKey="Morris A">AP Morris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manning, Ak" uniqKey="Manning A">AK Manning</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teslovich, Tm" uniqKey="Teslovich T">TM Teslovich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Harst, P" uniqKey="Van Der Harst P">P van der Harst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gieger, C" uniqKey="Gieger C">C Gieger</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li><li>États-Unis</li></country><region><li>Californie</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>New York</li><li>Paris</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Pickrell, Joseph K" sort="Pickrell, Joseph K" uniqKey="Pickrell J" first="Joseph K." last="Pickrell">Joseph K. Pickrell</name></region><name sortKey="Berisa, Tomaz" sort="Berisa, Tomaz" uniqKey="Berisa T" first="Tomaz" last="Berisa">Tomaz Berisa</name><name sortKey="Hinds, David" sort="Hinds, David" uniqKey="Hinds D" first="David" last="Hinds">David Hinds</name><name sortKey="Liu, Jimmy Z" sort="Liu, Jimmy Z" uniqKey="Liu J" first="Jimmy Z." last="Liu">Jimmy Z. Liu</name><name sortKey="Pickrell, Joseph K" sort="Pickrell, Joseph K" uniqKey="Pickrell J" first="Joseph K." last="Pickrell">Joseph K. Pickrell</name><name sortKey="Tung, Joyce Y" sort="Tung, Joyce Y" uniqKey="Tung J" first="Joyce Y." last="Tung">Joyce Y. Tung</name></country><country name="France"><region name="Île-de-France"><name sortKey="Segurel, Laure" sort="Segurel, Laure" uniqKey="Segurel L" first="Laure" last="Segurel">Laure Segurel</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A21 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 001A21 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Ncbi
|étape= Checkpoint
|type= RBID
|clé= PMC:5207801
|texte= Detection and interpretation of shared genetic influences on 42 human traits
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:27182965" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |