Optimizing Western Blots for the Detection of Endogenous α-Synuclein in the Enteric Nervous System.
Identifieur interne : 001881 ( Ncbi/Checkpoint ); précédent : 001880; suivant : 001882Optimizing Western Blots for the Detection of Endogenous α-Synuclein in the Enteric Nervous System.
Auteurs : Cécile Preterre [France] ; Anne-Gaëlle Corbillé [France] ; Gaëlle Balloy [France] ; Franck Letournel [France] ; Michel Neunlist [France] ; Pascal Derkinderen [France]Source :
- Journal of Parkinson's disease [ 1877-718X ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : alpha-Synuclein.
- chemical , metabolism : Biomarkers.
- diagnosis : Parkinson Disease.
- innervation : Intestine, Small.
- metabolism : Enteric Nervous System, Intestine, Small.
- methods : Blotting, Western.
- standards : Blotting, Western.
- Animals, Humans, Rats.
Abstract
Alpha-synuclein containing inclusions in neurons, the characteristic pathological lesions of Parkinson's disease (PD), are not limited to the central nervous system, but also affect the enteric nervous system (ENS). This suggests that the ENS offer some potential as a surrogate of central nervous system pathology and that it may represent an original source of biomarkers for PD. However, the usefulness of α-synuclein detection in gastrointestinal biopsies as a biomarker for PD is still unclear, as the different immunohistochemical methods employed to date have led to conflicting results.
DOI: 10.3233/JPD-150670
PubMed: 26599299
Affiliations:
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pubmed:26599299Le document en format XML
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<term>Enteric Nervous System (metabolism)</term>
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<term>Intestine, Small (innervation)</term>
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<front><div type="abstract" xml:lang="en">Alpha-synuclein containing inclusions in neurons, the characteristic pathological lesions of Parkinson's disease (PD), are not limited to the central nervous system, but also affect the enteric nervous system (ENS). This suggests that the ENS offer some potential as a surrogate of central nervous system pathology and that it may represent an original source of biomarkers for PD. However, the usefulness of α-synuclein detection in gastrointestinal biopsies as a biomarker for PD is still unclear, as the different immunohistochemical methods employed to date have led to conflicting results.</div>
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<name sortKey="Balloy, Gaelle" sort="Balloy, Gaelle" uniqKey="Balloy G" first="Gaëlle" last="Balloy">Gaëlle Balloy</name>
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