CSF IgA NMDAR antibodies are potential biomarkers for teratomas in anti-NMDAR encephalitis
Identifieur interne : 001873 ( Ncbi/Checkpoint ); précédent : 001872; suivant : 001874CSF IgA NMDAR antibodies are potential biomarkers for teratomas in anti-NMDAR encephalitis
Auteurs : Virginie Desestret ; Aude Chefdeville ; Aurélien Viaccoz ; Chloe Bost ; François Ducray ; Géraldine Picard ; Veronique Rogemond ; Marie-Oceane Chaffois ; Charlotte Blanc ; Claire Bardel ; Isabelle Treilleux ; Olivier Pascual ; Jean-Christophe Antoine ; Jean-Yves Delattre ; Jerome HonnoratSource :
- Neurology® Neuroimmunology & Neuroinflammation [ 2332-7812 ] ; 2015.
Abstract
To evaluate the presence of immunoglobulin A (IgA) subtype of anti-NMDA receptor (NMDAR) antibodies (IgA-NMDAR-Abs) in the CSF of patients with immunoglobulin G (IgG)-NMDAR-Ab encephalitis and to describe the potential association with a specific clinical pattern.
The retrospective analysis for the presence of IgA-NMDAR-Abs in 94 CSF samples from patients with anti-NMDAR encephalitis diagnosed between October 2007 and February 2014 was conducted at the French Reference Centre on Paraneoplastic Neurological Syndrome. This observational study compared 39 patients with both IgA- and IgG-NMDAR-Abs to 55 patients with only IgG-NMDAR-Abs.
In the retrospective cohort, 41% of the patients with NMDAR-Ab encephalitis had both CSF IgG- and IgA-NMDAR-Abs. Approximately half of the IgA-NMDAR-Ab-positive patients (18/38, 49%) definitively possessed associated tumors, primarily ovarian teratomas (17/18, 94%), compared with only 5% (3/55) of the patients in the IgA-NMDAR-Ab-negative group (
These results suggest that in patients with IgG-NMDAR-Ab encephalitis, CSF IgA-NMDAR-Abs could be used as a biological marker for the presence of an ovarian teratoma.
Url:
DOI: 10.1212/NXI.0000000000000166
PubMed: 26568967
PubMed Central: 4630685
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">CSF IgA NMDAR antibodies are potential biomarkers for teratomas in anti-NMDAR encephalitis</title><author><name sortKey="Desestret, Virginie" sort="Desestret, Virginie" uniqKey="Desestret V" first="Virginie" last="Desestret">Virginie Desestret</name></author><author><name sortKey="Chefdeville, Aude" sort="Chefdeville, Aude" uniqKey="Chefdeville A" first="Aude" last="Chefdeville">Aude Chefdeville</name></author><author><name sortKey="Viaccoz, Aurelien" sort="Viaccoz, Aurelien" uniqKey="Viaccoz A" first="Aurélien" last="Viaccoz">Aurélien Viaccoz</name></author><author><name sortKey="Bost, Chloe" sort="Bost, Chloe" uniqKey="Bost C" first="Chloe" last="Bost">Chloe Bost</name></author><author><name sortKey="Ducray, Francois" sort="Ducray, Francois" uniqKey="Ducray F" first="François" last="Ducray">François Ducray</name></author><author><name sortKey="Picard, Geraldine" sort="Picard, Geraldine" uniqKey="Picard G" first="Géraldine" last="Picard">Géraldine Picard</name></author><author><name sortKey="Rogemond, Veronique" sort="Rogemond, Veronique" uniqKey="Rogemond V" first="Veronique" last="Rogemond">Veronique Rogemond</name></author><author><name sortKey="Chaffois, Marie Oceane" sort="Chaffois, Marie Oceane" uniqKey="Chaffois M" first="Marie-Oceane" last="Chaffois">Marie-Oceane Chaffois</name></author><author><name sortKey="Blanc, Charlotte" sort="Blanc, Charlotte" uniqKey="Blanc C" first="Charlotte" last="Blanc">Charlotte Blanc</name></author><author><name sortKey="Bardel, Claire" sort="Bardel, Claire" uniqKey="Bardel C" first="Claire" last="Bardel">Claire Bardel</name></author><author><name sortKey="Treilleux, Isabelle" sort="Treilleux, Isabelle" uniqKey="Treilleux I" first="Isabelle" last="Treilleux">Isabelle Treilleux</name></author><author><name sortKey="Pascual, Olivier" sort="Pascual, Olivier" uniqKey="Pascual O" first="Olivier" last="Pascual">Olivier Pascual</name></author><author><name sortKey="Antoine, Jean Christophe" sort="Antoine, Jean Christophe" uniqKey="Antoine J" first="Jean-Christophe" last="Antoine">Jean-Christophe Antoine</name></author><author><name sortKey="Delattre, Jean Yves" sort="Delattre, Jean Yves" uniqKey="Delattre J" first="Jean-Yves" last="Delattre">Jean-Yves Delattre</name></author><author><name sortKey="Honnorat, Jerome" sort="Honnorat, Jerome" uniqKey="Honnorat J" first="Jerome" last="Honnorat">Jerome Honnorat</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26568967</idno><idno type="pmc">4630685</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630685</idno><idno type="RBID">PMC:4630685</idno><idno type="doi">10.1212/NXI.0000000000000166</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000070</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000070</idno><idno type="wicri:Area/Pmc/Curation">000070</idno><idno 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last="Viaccoz">Aurélien Viaccoz</name></author><author><name sortKey="Bost, Chloe" sort="Bost, Chloe" uniqKey="Bost C" first="Chloe" last="Bost">Chloe Bost</name></author><author><name sortKey="Ducray, Francois" sort="Ducray, Francois" uniqKey="Ducray F" first="François" last="Ducray">François Ducray</name></author><author><name sortKey="Picard, Geraldine" sort="Picard, Geraldine" uniqKey="Picard G" first="Géraldine" last="Picard">Géraldine Picard</name></author><author><name sortKey="Rogemond, Veronique" sort="Rogemond, Veronique" uniqKey="Rogemond V" first="Veronique" last="Rogemond">Veronique Rogemond</name></author><author><name sortKey="Chaffois, Marie Oceane" sort="Chaffois, Marie Oceane" uniqKey="Chaffois M" first="Marie-Oceane" last="Chaffois">Marie-Oceane Chaffois</name></author><author><name sortKey="Blanc, Charlotte" sort="Blanc, Charlotte" uniqKey="Blanc C" first="Charlotte" last="Blanc">Charlotte Blanc</name></author><author><name sortKey="Bardel, Claire" sort="Bardel, Claire" uniqKey="Bardel C" first="Claire" last="Bardel">Claire Bardel</name></author><author><name sortKey="Treilleux, Isabelle" sort="Treilleux, Isabelle" uniqKey="Treilleux I" first="Isabelle" last="Treilleux">Isabelle Treilleux</name></author><author><name sortKey="Pascual, Olivier" sort="Pascual, Olivier" uniqKey="Pascual O" first="Olivier" last="Pascual">Olivier Pascual</name></author><author><name sortKey="Antoine, Jean Christophe" sort="Antoine, Jean Christophe" uniqKey="Antoine J" first="Jean-Christophe" last="Antoine">Jean-Christophe Antoine</name></author><author><name sortKey="Delattre, Jean Yves" sort="Delattre, Jean Yves" uniqKey="Delattre J" first="Jean-Yves" last="Delattre">Jean-Yves Delattre</name></author><author><name sortKey="Honnorat, Jerome" sort="Honnorat, Jerome" uniqKey="Honnorat J" first="Jerome" last="Honnorat">Jerome Honnorat</name></author></analytic><series><title level="j">Neurology® Neuroimmunology & Neuroinflammation</title><idno type="eISSN">2332-7812</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective:</title><p>To evaluate the presence of immunoglobulin A (IgA) subtype of anti-NMDA receptor (NMDAR) antibodies (IgA-NMDAR-Abs) in the CSF of patients with immunoglobulin G (IgG)-NMDAR-Ab encephalitis and to describe the potential association with a specific clinical pattern.</p></sec><sec><title>Methods:</title><p>The retrospective analysis for the presence of IgA-NMDAR-Abs in 94 CSF samples from patients with anti-NMDAR encephalitis diagnosed between October 2007 and February 2014 was conducted at the French Reference Centre on Paraneoplastic Neurological Syndrome. This observational study compared 39 patients with both IgA- and IgG-NMDAR-Abs to 55 patients with only IgG-NMDAR-Abs.</p></sec><sec><title>Results:</title><p>In the retrospective cohort, 41% of the patients with NMDAR-Ab encephalitis had both CSF IgG- and IgA-NMDAR-Abs. Approximately half of the IgA-NMDAR-Ab-positive patients (18/38, 49%) definitively possessed associated tumors, primarily ovarian teratomas (17/18, 94%), compared with only 5% (3/55) of the patients in the IgA-NMDAR-Ab-negative group (<italic>p</italic> < 0.001). In the adult female population at risk for ovarian teratoma, the detection of CSF IgA-NMDAR-Ab positivity showed 85% sensitivity, 70% specificity, a 57% positive predictive value, and a 90% negative predictive value for the diagnosis of ovarian teratoma. No other specific clinical features or clinical outcome were associated with CSF IgA-NMDAR-Ab positivity.</p></sec><sec><title>Conclusion:</title><p>These results suggest that in patients with IgG-NMDAR-Ab encephalitis, CSF IgA-NMDAR-Abs could be used as a biological marker for the presence of an ovarian teratoma.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hughes, Eg" uniqKey="Hughes E">EG Hughes</name></author><author><name sortKey="Peng, X" uniqKey="Peng X">X Peng</name></author><author><name sortKey="Gleichman, Aj" uniqKey="Gleichman A">AJ Gleichman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mikasova, L" uniqKey="Mikasova L">L Mikasova</name></author><author><name sortKey="De Rossi, P" uniqKey="De Rossi P">P De Rossi</name></author><author><name sortKey="Bouchet, D" uniqKey="Bouchet D">D Bouchet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Planaguma, J" uniqKey="Planaguma J">J Planaguma</name></author><author><name sortKey="Leypoldt, F" uniqKey="Leypoldt F">F Leypoldt</name></author><author><name sortKey="Mannara, F" uniqKey="Mannara F">F Mannara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gresa Arribas, N" uniqKey="Gresa Arribas N">N Gresa-Arribas</name></author><author><name sortKey="Titulaer, Mj" uniqKey="Titulaer M">MJ Titulaer</name></author><author><name sortKey="Torrents, A" uniqKey="Torrents A">A Torrents</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lancaster, E" uniqKey="Lancaster E">E Lancaster</name></author><author><name sortKey="Leypoldt, F" uniqKey="Leypoldt F">F Leypoldt</name></author><author><name sortKey="Titulaer, Mj" uniqKey="Titulaer M">MJ Titulaer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pruss, H" uniqKey="Pruss H">H Prüss</name></author><author><name sortKey="Klingbeil, C" uniqKey="Klingbeil C">C Klingbeil</name></author><author><name sortKey="Probst, C" uniqKey="Probst C">C Probst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dahm, L" uniqKey="Dahm L">L Dahm</name></author><author><name sortKey="Ott, C" uniqKey="Ott C">C Ott</name></author><author><name sortKey="Steiner, J" uniqKey="Steiner J">J Steiner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Doss, S" uniqKey="Doss S">S Doss</name></author><author><name sortKey="Wandinger, Kp" uniqKey="Wandinger K">KP Wandinger</name></author><author><name sortKey="Hyman, Bt" uniqKey="Hyman B">BT Hyman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dalmau, J" uniqKey="Dalmau J">J Dalmau</name></author><author><name sortKey="Gleichman, Aj" uniqKey="Gleichman A">AJ Gleichman</name></author><author><name sortKey="Hughes, Eg" uniqKey="Hughes E">EG Hughes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reiber, H" uniqKey="Reiber H">H Reiber</name></author><author><name sortKey="Peter, Jb" uniqKey="Peter J">JB Peter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Viaccoz, A" uniqKey="Viaccoz A">A Viaccoz</name></author><author><name sortKey="Desestret, V" uniqKey="Desestret V">V Desestret</name></author><author><name sortKey="Ducray, F" uniqKey="Ducray F">F Ducray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Setterfield, J" uniqKey="Setterfield J">J Setterfield</name></author><author><name sortKey="Shirlaw, Pj" uniqKey="Shirlaw P">PJ Shirlaw</name></author><author><name sortKey="Kerr Muir, M" uniqKey="Kerr Muir M">M Kerr-Muir</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cozzani, E" uniqKey="Cozzani E">E Cozzani</name></author><author><name sortKey="Drosera, M" uniqKey="Drosera M">M Drosera</name></author><author><name sortKey="Parodi, A" uniqKey="Parodi A">A Parodi</name></author><author><name sortKey="Carrozzo, M" uniqKey="Carrozzo M">M Carrozzo</name></author><author><name sortKey="Gandolfo, S" uniqKey="Gandolfo S">S Gandolfo</name></author><author><name sortKey="Rebora, A" uniqKey="Rebora A">A Rebora</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Antoine, Jean Christophe" sort="Antoine, Jean Christophe" uniqKey="Antoine J" first="Jean-Christophe" last="Antoine">Jean-Christophe Antoine</name><name sortKey="Bardel, Claire" sort="Bardel, Claire" uniqKey="Bardel C" first="Claire" last="Bardel">Claire Bardel</name><name sortKey="Blanc, Charlotte" sort="Blanc, Charlotte" uniqKey="Blanc C" first="Charlotte" last="Blanc">Charlotte Blanc</name><name sortKey="Bost, Chloe" sort="Bost, Chloe" uniqKey="Bost C" first="Chloe" last="Bost">Chloe Bost</name><name sortKey="Chaffois, Marie Oceane" sort="Chaffois, Marie Oceane" uniqKey="Chaffois M" first="Marie-Oceane" last="Chaffois">Marie-Oceane Chaffois</name><name sortKey="Chefdeville, Aude" sort="Chefdeville, Aude" uniqKey="Chefdeville A" first="Aude" last="Chefdeville">Aude Chefdeville</name><name sortKey="Delattre, Jean Yves" sort="Delattre, Jean Yves" uniqKey="Delattre J" first="Jean-Yves" last="Delattre">Jean-Yves Delattre</name><name sortKey="Desestret, Virginie" sort="Desestret, Virginie" uniqKey="Desestret V" first="Virginie" last="Desestret">Virginie Desestret</name><name sortKey="Ducray, Francois" sort="Ducray, Francois" uniqKey="Ducray F" first="François" last="Ducray">François Ducray</name><name sortKey="Honnorat, Jerome" sort="Honnorat, Jerome" uniqKey="Honnorat J" first="Jerome" last="Honnorat">Jerome Honnorat</name><name sortKey="Pascual, Olivier" sort="Pascual, Olivier" uniqKey="Pascual O" first="Olivier" last="Pascual">Olivier Pascual</name><name sortKey="Picard, Geraldine" sort="Picard, Geraldine" uniqKey="Picard G" first="Géraldine" last="Picard">Géraldine Picard</name><name sortKey="Rogemond, Veronique" sort="Rogemond, Veronique" uniqKey="Rogemond V" first="Veronique" last="Rogemond">Veronique Rogemond</name><name sortKey="Treilleux, Isabelle" sort="Treilleux, Isabelle" uniqKey="Treilleux I" first="Isabelle" last="Treilleux">Isabelle Treilleux</name><name sortKey="Viaccoz, Aurelien" sort="Viaccoz, Aurelien" uniqKey="Viaccoz A" first="Aurélien" last="Viaccoz">Aurélien Viaccoz</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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