La maladie de Parkinson en France (serveur d'exploration)

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Iron Metabolism Disturbance in a French Cohort of ALS Patients

Identifieur interne : 001474 ( Ncbi/Checkpoint ); précédent : 001473; suivant : 001475

Iron Metabolism Disturbance in a French Cohort of ALS Patients

Auteurs : Charlotte Veyrat-Durebex [France] ; Philippe Corcia [France] ; Aleksandra Mucha [France] ; Simon Benzimra [France] ; Cindy Mallet [France] ; Chantal Gendrot [France] ; Caroline Moreau [France] ; David Devos [France] ; Eric Piver [France] ; Jean-Christophe Pagès [France] ; François Maillot [France] ; Christian R. Andres [France] ; Patrick Vourc'H [France] ; Hélène Blasco [France]

Source :

RBID : PMC:4101961

Abstract

Objective. The aim of this study was to assess iron status in a cohort of amyotrophic lateral sclerosis (ALS) patients compared to controls in order to evaluate these parameters as a risk factor or a modifying factor of ALS. Methods. We collected serum iron, ferritin, transferrin, total iron-binding capacity, and transferrin saturation coefficient (TSC) from 104 ALS patients at the time of diagnosis and from 145 controls. We reported phenotypic characteristics and evolution parameters such as ALSFRS-R and forced vital capacity at diagnosis and after one year of follow-up. In a first step we compared iron status between ALS patients and controls, and then we evaluated the relation between iron status and disease evolution of ALS patients using univariate and multivariate analysis. Results. We observed increased concentrations of serum iron (P = 0.002) and ferritin (P < 0.0001) and increased TSC (P = 0.017) in ALS patients. We also showed an association between markers of iron status and high body weight loss in ALS patients. The multivariate analysis of survival highlighted a significant relation between ferritin level and disease duration (P = 0.038). Conclusion. This is the first study showing a higher concentration of serum iron in ALS patients, strengthening the involvement of a deregulation of iron metabolism in ALS.


Url:
DOI: 10.1155/2014/485723
PubMed: 25101285
PubMed Central: 4101961


Affiliations:


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PMC:4101961

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<name sortKey="Maillot, Francois" sort="Maillot, Francois" uniqKey="Maillot F" first="François" last="Maillot">François Maillot</name>
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<name sortKey="Andres, Christian R" sort="Andres, Christian R" uniqKey="Andres C" first="Christian R." last="Andres">Christian R. Andres</name>
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<name sortKey="Blasco, Helene" sort="Blasco, Helene" uniqKey="Blasco H" first="Hélène" last="Blasco">Hélène Blasco</name>
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<title xml:lang="en" level="a" type="main">Iron Metabolism Disturbance in a French Cohort of ALS Patients</title>
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<name sortKey="Mucha, Aleksandra" sort="Mucha, Aleksandra" uniqKey="Mucha A" first="Aleksandra" last="Mucha">Aleksandra Mucha</name>
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<name sortKey="Benzimra, Simon" sort="Benzimra, Simon" uniqKey="Benzimra S" first="Simon" last="Benzimra">Simon Benzimra</name>
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<name sortKey="Mallet, Cindy" sort="Mallet, Cindy" uniqKey="Mallet C" first="Cindy" last="Mallet">Cindy Mallet</name>
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<name sortKey="Gendrot, Chantal" sort="Gendrot, Chantal" uniqKey="Gendrot C" first="Chantal" last="Gendrot">Chantal Gendrot</name>
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<nlm:aff id="I2">Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours</wicri:regionArea>
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<region type="old region" nuts="2">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Moreau, Caroline" sort="Moreau, Caroline" uniqKey="Moreau C" first="Caroline" last="Moreau">Caroline Moreau</name>
<affiliation wicri:level="3">
<nlm:aff id="I4">Service de Neurologie, Centre Hospitalier Régional Universitaire de Lille, 59037 Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Neurologie, Centre Hospitalier Régional Universitaire de Lille, 59037 Lille</wicri:regionArea>
<placeName>
<region type="region" nuts="2">Hauts-de-France</region>
<region type="old region" nuts="2">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Devos, David" sort="Devos, David" uniqKey="Devos D" first="David" last="Devos">David Devos</name>
<affiliation wicri:level="3">
<nlm:aff id="I4">Service de Neurologie, Centre Hospitalier Régional Universitaire de Lille, 59037 Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Neurologie, Centre Hospitalier Régional Universitaire de Lille, 59037 Lille</wicri:regionArea>
<placeName>
<region type="region" nuts="2">Hauts-de-France</region>
<region type="old region" nuts="2">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Piver, Eric" sort="Piver, Eric" uniqKey="Piver E" first="Eric" last="Piver">Eric Piver</name>
<affiliation wicri:level="3">
<nlm:aff id="I5">Laboratoire de Biochimie, Hôpital Trousseau, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Biochimie, Hôpital Trousseau, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours</wicri:regionArea>
<placeName>
<region type="region" nuts="2">Centre-Val de Loire</region>
<region type="old region" nuts="2">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Pages, Jean Christophe" sort="Pages, Jean Christophe" uniqKey="Pages J" first="Jean-Christophe" last="Pagès">Jean-Christophe Pagès</name>
<affiliation wicri:level="3">
<nlm:aff id="I5">Laboratoire de Biochimie, Hôpital Trousseau, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Biochimie, Hôpital Trousseau, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours</wicri:regionArea>
<placeName>
<region type="region" nuts="2">Centre-Val de Loire</region>
<region type="old region" nuts="2">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Maillot, Francois" sort="Maillot, Francois" uniqKey="Maillot F" first="François" last="Maillot">François Maillot</name>
<affiliation wicri:level="3">
<nlm:aff id="I6">Service de Médecine Interne, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Interne, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours</wicri:regionArea>
<placeName>
<region type="region" nuts="2">Centre-Val de Loire</region>
<region type="old region" nuts="2">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Andres, Christian R" sort="Andres, Christian R" uniqKey="Andres C" first="Christian R." last="Andres">Christian R. Andres</name>
<affiliation wicri:level="3">
<nlm:aff id="I1">Unité Mixte de Recherche U930, Institut National de la Santé et de la Recherche Médicale, Université François-Rabelais, Equipe “Neurogénétique et Neurométabolomique”, 10 boulevard Tonnellé, 37032 Tours, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité Mixte de Recherche U930, Institut National de la Santé et de la Recherche Médicale, Université François-Rabelais, Equipe “Neurogénétique et Neurométabolomique”, 10 boulevard Tonnellé, 37032 Tours</wicri:regionArea>
<placeName>
<region type="region" nuts="2">Centre-Val de Loire</region>
<region type="old region" nuts="2">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="I2">Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours</wicri:regionArea>
<placeName>
<region type="region" nuts="2">Centre-Val de Loire</region>
<region type="old region" nuts="2">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Vourc H, Patrick" sort="Vourc H, Patrick" uniqKey="Vourc H P" first="Patrick" last="Vourc'H">Patrick Vourc'H</name>
<affiliation wicri:level="3">
<nlm:aff id="I1">Unité Mixte de Recherche U930, Institut National de la Santé et de la Recherche Médicale, Université François-Rabelais, Equipe “Neurogénétique et Neurométabolomique”, 10 boulevard Tonnellé, 37032 Tours, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité Mixte de Recherche U930, Institut National de la Santé et de la Recherche Médicale, Université François-Rabelais, Equipe “Neurogénétique et Neurométabolomique”, 10 boulevard Tonnellé, 37032 Tours</wicri:regionArea>
<placeName>
<region type="region" nuts="2">Centre-Val de Loire</region>
<region type="old region" nuts="2">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="I2">Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours</wicri:regionArea>
<placeName>
<region type="region" nuts="2">Centre-Val de Loire</region>
<region type="old region" nuts="2">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Blasco, Helene" sort="Blasco, Helene" uniqKey="Blasco H" first="Hélène" last="Blasco">Hélène Blasco</name>
<affiliation wicri:level="3">
<nlm:aff id="I1">Unité Mixte de Recherche U930, Institut National de la Santé et de la Recherche Médicale, Université François-Rabelais, Equipe “Neurogénétique et Neurométabolomique”, 10 boulevard Tonnellé, 37032 Tours, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité Mixte de Recherche U930, Institut National de la Santé et de la Recherche Médicale, Université François-Rabelais, Equipe “Neurogénétique et Neurométabolomique”, 10 boulevard Tonnellé, 37032 Tours</wicri:regionArea>
<placeName>
<region type="region" nuts="2">Centre-Val de Loire</region>
<region type="old region" nuts="2">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="I2">Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours</wicri:regionArea>
<placeName>
<region type="region" nuts="2">Centre-Val de Loire</region>
<region type="old region" nuts="2">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series>
<title level="j">BioMed Research International</title>
<idno type="ISSN">2314-6133</idno>
<idno type="eISSN">2314-6141</idno>
<imprint>
<date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<p>
<italic>Objective.</italic>
The aim of this study was to assess iron status in a cohort of amyotrophic lateral sclerosis (ALS) patients compared to controls in order to evaluate these parameters as a risk factor or a modifying factor of ALS.
<italic>Methods.</italic>
We collected serum iron, ferritin, transferrin, total iron-binding capacity, and transferrin saturation coefficient (TSC) from 104 ALS patients at the time of diagnosis and from 145 controls. We reported phenotypic characteristics and evolution parameters such as ALSFRS-R and forced vital capacity at diagnosis and after one year of follow-up. In a first step we compared iron status between ALS patients and controls, and then we evaluated the relation between iron status and disease evolution of ALS patients using univariate and multivariate analysis.
<italic>Results.</italic>
We observed increased concentrations of serum iron (
<italic>P</italic>
= 0.002) and ferritin (
<italic>P</italic>
< 0.0001) and increased TSC (
<italic>P</italic>
= 0.017) in ALS patients. We also showed an association between markers of iron status and high body weight loss in ALS patients. The multivariate analysis of survival highlighted a significant relation between ferritin level and disease duration (
<italic>P</italic>
= 0.038).
<italic>Conclusion.</italic>
This is the first study showing a higher concentration of serum iron in ALS patients, strengthening the involvement of a deregulation of iron metabolism in ALS. </p>
</div>
</front>
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<li>France</li>
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<li>Centre-Val de Loire</li>
<li>Hauts-de-France</li>
<li>Nord-Pas-de-Calais</li>
<li>Région Centre</li>
</region>
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<li>Lille</li>
<li>Tours</li>
</settlement>
</list>
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<name sortKey="Veyrat Durebex, Charlotte" sort="Veyrat Durebex, Charlotte" uniqKey="Veyrat Durebex C" first="Charlotte" last="Veyrat-Durebex">Charlotte Veyrat-Durebex</name>
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<name sortKey="Andres, Christian R" sort="Andres, Christian R" uniqKey="Andres C" first="Christian R." last="Andres">Christian R. Andres</name>
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<name sortKey="Blasco, Helene" sort="Blasco, Helene" uniqKey="Blasco H" first="Hélène" last="Blasco">Hélène Blasco</name>
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<name sortKey="Corcia, Philippe" sort="Corcia, Philippe" uniqKey="Corcia P" first="Philippe" last="Corcia">Philippe Corcia</name>
<name sortKey="Corcia, Philippe" sort="Corcia, Philippe" uniqKey="Corcia P" first="Philippe" last="Corcia">Philippe Corcia</name>
<name sortKey="Devos, David" sort="Devos, David" uniqKey="Devos D" first="David" last="Devos">David Devos</name>
<name sortKey="Gendrot, Chantal" sort="Gendrot, Chantal" uniqKey="Gendrot C" first="Chantal" last="Gendrot">Chantal Gendrot</name>
<name sortKey="Maillot, Francois" sort="Maillot, Francois" uniqKey="Maillot F" first="François" last="Maillot">François Maillot</name>
<name sortKey="Mallet, Cindy" sort="Mallet, Cindy" uniqKey="Mallet C" first="Cindy" last="Mallet">Cindy Mallet</name>
<name sortKey="Moreau, Caroline" sort="Moreau, Caroline" uniqKey="Moreau C" first="Caroline" last="Moreau">Caroline Moreau</name>
<name sortKey="Mucha, Aleksandra" sort="Mucha, Aleksandra" uniqKey="Mucha A" first="Aleksandra" last="Mucha">Aleksandra Mucha</name>
<name sortKey="Pages, Jean Christophe" sort="Pages, Jean Christophe" uniqKey="Pages J" first="Jean-Christophe" last="Pagès">Jean-Christophe Pagès</name>
<name sortKey="Piver, Eric" sort="Piver, Eric" uniqKey="Piver E" first="Eric" last="Piver">Eric Piver</name>
<name sortKey="Veyrat Durebex, Charlotte" sort="Veyrat Durebex, Charlotte" uniqKey="Veyrat Durebex C" first="Charlotte" last="Veyrat-Durebex">Charlotte Veyrat-Durebex</name>
<name sortKey="Vourc H, Patrick" sort="Vourc H, Patrick" uniqKey="Vourc H P" first="Patrick" last="Vourc'H">Patrick Vourc'H</name>
<name sortKey="Vourc H, Patrick" sort="Vourc H, Patrick" uniqKey="Vourc H P" first="Patrick" last="Vourc'H">Patrick Vourc'H</name>
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</record>

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