Manganese-Induced Atypical Parkinsonism Is Associated with Altered Basal Ganglia Activity and Changes in Tissue Levels of Monoamines in the Rat
Identifieur interne : 001420 ( Ncbi/Checkpoint ); précédent : 001419; suivant : 001421Manganese-Induced Atypical Parkinsonism Is Associated with Altered Basal Ganglia Activity and Changes in Tissue Levels of Monoamines in the Rat
Auteurs : Safa Bouabid [France, Maroc] ; Claire Delaville [France] ; Philippe De Deurwaerdère [France] ; Nouria Lakhdar-Ghazal [Maroc] ; Abdelhamid Benazzouz [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
English descriptors
- KwdEn :
- Animals, Anxiety (chemically induced), Basal Ganglia (drug effects), Basal Ganglia (pathology), Body Weight (drug effects), Dopamine (metabolism), Electrophysiology, Globus Pallidus (drug effects), Globus Pallidus (pathology), Locomotion (drug effects), Male, Manganese (toxicity), Neurons (drug effects), Neurons (pathology), Norepinephrine (metabolism), Parkinson Disease (etiology), Parkinson Disease (metabolism), Rats, Rats, Sprague-Dawley, Serotonin (metabolism), Subthalamic Nucleus (drug effects), Subthalamic Nucleus (pathology), Synaptic Transmission (drug effects).
- MESH :
- chemical , metabolism : Dopamine, Norepinephrine, Serotonin.
- chemically induced : Anxiety.
- drug effects : Basal Ganglia, Body Weight, Globus Pallidus, Locomotion, Neurons, Subthalamic Nucleus, Synaptic Transmission.
- etiology : Parkinson Disease.
- metabolism : Parkinson Disease.
- pathology : Basal Ganglia, Globus Pallidus, Neurons, Subthalamic Nucleus.
- chemical , toxicity : Manganese.
- Animals, Electrophysiology, Male, Rats, Rats, Sprague-Dawley.
Abstract
Manganese neurotoxicity is associated with motor and cognitive disturbances known as Manganism. However, the mechanisms underlying these deficits remain unknown. Here we investigated the effects of manganese intoxication on motor and non-motor parkinsonian-like deficits such as locomotor activity, motor coordination, anxiety and “depressive-like” behaviors. Then, we studied the impact of this intoxication on the neuronal activity, the globus pallidus (GP) and subthalamic nucleus (STN). At the end of experiments, post-mortem tissue level of the three monoamines (dopamine, norepinephrine and serotonin) has been determined. The experiments were carried out in adult Sprague-Dawley rats, daily treated with MnCl2 (10 mg/kg/, i.p.) for 5 weeks. We show that manganese progressively reduced locomotor activity as well as motor coordination in parallel with the manifestation of anxiety and “depressive-like” behaviors. Electrophysiological results show that, while majority of GP and STN neurons discharged regularly in controls, manganese increased the number of GP and STN neurons discharging irregularly and/or with bursts. Biochemical results show that manganese significantly decreased tissue levels of norepinephrine and serotonin with increased metabolism of dopamine in the striatum. Our data provide evidence that manganese intoxication is associated with impaired neurotransmission of monoaminergic systems, which is at the origin of changes in basal ganglia neuronal activity and the manifestation of motor and non-motor deficits similar to those observed in atypical Parkinsonism.
Url:
DOI: 10.1371/journal.pone.0098952
PubMed: 24896650
PubMed Central: 4045849
Affiliations:
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type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="De Deurwaerdere, Philippe" sort="De Deurwaerdere, Philippe" uniqKey="De Deurwaerdere P" first="Philippe" last="De Deurwaerdère">Philippe De Deurwaerdère</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. de Bordeaux, Institut des Maladies 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Rythmes Biologiques, Neurosciences et Environnement, Rabat, Morocco</addr-line></nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Université Mohamed V-Agdal, Faculté des Sciences, Equipe Rythmes Biologiques, Neurosciences et Environnement, Rabat</wicri:regionArea><placeName><settlement type="city">Rabat</settlement><region nuts="2">Rabat-Salé-Kénitra</region></placeName></affiliation></author><author><name sortKey="Benazzouz, Abdelhamid" sort="Benazzouz, Abdelhamid" uniqKey="Benazzouz A" first="Abdelhamid" last="Benazzouz">Abdelhamid Benazzouz</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Anxiety (chemically induced)</term><term>Basal Ganglia (drug effects)</term><term>Basal Ganglia (pathology)</term><term>Body Weight (drug effects)</term><term>Dopamine (metabolism)</term><term>Electrophysiology</term><term>Globus Pallidus (drug effects)</term><term>Globus Pallidus (pathology)</term><term>Locomotion (drug effects)</term><term>Male</term><term>Manganese (toxicity)</term><term>Neurons (drug effects)</term><term>Neurons (pathology)</term><term>Norepinephrine (metabolism)</term><term>Parkinson Disease (etiology)</term><term>Parkinson Disease (metabolism)</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Serotonin (metabolism)</term><term>Subthalamic Nucleus (drug effects)</term><term>Subthalamic Nucleus (pathology)</term><term>Synaptic Transmission (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term><term>Norepinephrine</term><term>Serotonin</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Anxiety</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Basal Ganglia</term><term>Body Weight</term><term>Globus Pallidus</term><term>Locomotion</term><term>Neurons</term><term>Subthalamic Nucleus</term><term>Synaptic Transmission</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Basal Ganglia</term><term>Globus Pallidus</term><term>Neurons</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Manganese</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Electrophysiology</term><term>Male</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Manganese neurotoxicity is associated with motor and cognitive disturbances known as Manganism. However, the mechanisms underlying these deficits remain unknown. Here we investigated the effects of manganese intoxication on motor and non-motor parkinsonian-like deficits such as locomotor activity, motor coordination, anxiety and “depressive-like” behaviors. Then, we studied the impact of this intoxication on the neuronal activity, the globus pallidus (GP) and subthalamic nucleus (STN). At the end of experiments, post-mortem tissue level of the three monoamines (dopamine, norepinephrine and serotonin) has been determined. The experiments were carried out in adult Sprague-Dawley rats, daily treated with MnCl<sub>2</sub> (10 mg/kg/, i.p.) for 5 weeks. We show that manganese progressively reduced locomotor activity as well as motor coordination in parallel with the manifestation of anxiety and “depressive-like” behaviors. Electrophysiological results show that, while majority of GP and STN neurons discharged regularly in controls, manganese increased the number of GP and STN neurons discharging irregularly and/or with bursts. Biochemical results show that manganese significantly decreased tissue levels of norepinephrine and serotonin with increased metabolism of dopamine in the striatum. Our data provide evidence that manganese intoxication is associated with impaired neurotransmission of monoaminergic systems, which is at the origin of changes in basal ganglia neuronal activity and the manifestation of motor and non-motor deficits similar to those observed in atypical Parkinsonism.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Aschner, M" uniqKey="Aschner M">M Aschner</name></author><author><name sortKey="Guilarte, Tr" uniqKey="Guilarte T">TR Guilarte</name></author><author><name sortKey="Schneider, Js" uniqKey="Schneider J">JS Schneider</name></author><author><name sortKey="Zheng, W" uniqKey="Zheng W">W Zheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takeda, A" uniqKey="Takeda A">A Takeda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aschner, M" uniqKey="Aschner M">M Aschner</name></author><author><name sortKey="Erikson, Km" 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Walters</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li><li>Maroc</li></country><region><li>Aquitaine</li><li>Nouvelle-Aquitaine</li><li>Rabat-Salé-Kénitra</li></region><settlement><li>Bordeaux</li><li>Rabat</li></settlement></list><tree><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Bouabid, Safa" sort="Bouabid, Safa" uniqKey="Bouabid S" first="Safa" last="Bouabid">Safa Bouabid</name></region><name sortKey="Benazzouz, Abdelhamid" sort="Benazzouz, Abdelhamid" uniqKey="Benazzouz A" first="Abdelhamid" last="Benazzouz">Abdelhamid Benazzouz</name><name sortKey="Benazzouz, Abdelhamid" sort="Benazzouz, Abdelhamid" uniqKey="Benazzouz A" first="Abdelhamid" last="Benazzouz">Abdelhamid Benazzouz</name><name sortKey="Bouabid, Safa" sort="Bouabid, Safa" uniqKey="Bouabid S" first="Safa" last="Bouabid">Safa Bouabid</name><name sortKey="De Deurwaerdere, Philippe" sort="De Deurwaerdere, Philippe" uniqKey="De Deurwaerdere P" first="Philippe" last="De Deurwaerdère">Philippe De Deurwaerdère</name><name sortKey="De Deurwaerdere, Philippe" sort="De Deurwaerdere, Philippe" uniqKey="De Deurwaerdere P" first="Philippe" last="De Deurwaerdère">Philippe De Deurwaerdère</name><name sortKey="Delaville, Claire" sort="Delaville, Claire" uniqKey="Delaville C" first="Claire" last="Delaville">Claire Delaville</name><name sortKey="Delaville, Claire" sort="Delaville, Claire" uniqKey="Delaville C" first="Claire" last="Delaville">Claire Delaville</name></country><country name="Maroc"><region name="Rabat-Salé-Kénitra"><name sortKey="Bouabid, Safa" sort="Bouabid, Safa" uniqKey="Bouabid S" first="Safa" last="Bouabid">Safa Bouabid</name></region><name sortKey="Lakhdar Ghazal, Nouria" sort="Lakhdar Ghazal, Nouria" uniqKey="Lakhdar Ghazal N" first="Nouria" last="Lakhdar-Ghazal">Nouria Lakhdar-Ghazal</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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