New targets for deep brain stimulation treatment of Parkinson's disease.
Identifieur interne : 001258 ( Ncbi/Checkpoint ); précédent : 001257; suivant : 001259New targets for deep brain stimulation treatment of Parkinson's disease.
Auteurs : Anna Castrioto [France] ; Elena MoroSource :
- Expert review of neurotherapeutics [ 1744-8360 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- methods : Deep Brain Stimulation.
- therapy : Parkinson Disease.
- Animals, Cognition, Humans, Quality of Life, Treatment Outcome.
Abstract
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and the globus pallidus pars interna (GPi) has been shown to be an effective treatment for patients with Parkinson's disease. Strong clinical evidence supports the improvement of motor and non-motor complications and quality of life, with some data suggesting that GPi DBS might be less effective than STN DBS. However, neither STN nor GPi stimulation provides a satisfactory control of non-dopaminergic symptoms, such as gait and balance impairment and cognitive decline, which are frequent and disabling symptoms in advanced Parkinson's disease patients. Therefore, several efforts have been made to discover alternative and new targets to overcome these current DBS limitations. Among these new targets, the stimulation of the pedunculopontine nucleus has initially appeared encouraging. However, findings from different double-blind trials have mitigated the enthusiasm. A multi-target strategy aimed at improving symptoms with different pathogenetic mechanisms might be a promising approach in the next years.
DOI: 10.1586/14737175.2013.859987
PubMed: 24215284
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000655
- to stream PubMed, to step Curation: 000627
- to stream PubMed, to step Checkpoint: 000627
- to stream Ncbi, to step Merge: 001258
- to stream Ncbi, to step Curation: 001258
Links to Exploration step
pubmed:24215284Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">New targets for deep brain stimulation treatment of Parkinson's disease.</title><author><name sortKey="Castrioto, Anna" sort="Castrioto, Anna" uniqKey="Castrioto A" first="Anna" last="Castrioto">Anna Castrioto</name><affiliation wicri:level="3"><nlm:affiliation>Movement Disorders Centre, Department of Psychiatry and Neurology, CHU de Grenoble - CS10217, 38043 Grenoble Cedex 09, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Movement Disorders Centre, Department of Psychiatry and Neurology, CHU de Grenoble - CS10217, 38043 Grenoble Cedex 09</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:24215284</idno><idno type="pmid">24215284</idno><idno type="doi">10.1586/14737175.2013.859987</idno><idno type="wicri:Area/PubMed/Corpus">000655</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000655</idno><idno type="wicri:Area/PubMed/Curation">000627</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000627</idno><idno type="wicri:Area/PubMed/Checkpoint">000627</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000627</idno><idno type="wicri:Area/Ncbi/Merge">001258</idno><idno type="wicri:Area/Ncbi/Curation">001258</idno><idno type="wicri:Area/Ncbi/Checkpoint">001258</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">New targets for deep brain stimulation treatment of Parkinson's disease.</title><author><name sortKey="Castrioto, Anna" sort="Castrioto, Anna" uniqKey="Castrioto A" first="Anna" last="Castrioto">Anna Castrioto</name><affiliation wicri:level="3"><nlm:affiliation>Movement Disorders Centre, Department of Psychiatry and Neurology, CHU de Grenoble - CS10217, 38043 Grenoble Cedex 09, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Movement Disorders Centre, Department of Psychiatry and Neurology, CHU de Grenoble - CS10217, 38043 Grenoble Cedex 09</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name></author></analytic><series><title level="j">Expert review of neurotherapeutics</title><idno type="eISSN">1744-8360</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cognition</term><term>Deep Brain Stimulation (methods)</term><term>Humans</term><term>Parkinson Disease (therapy)</term><term>Quality of Life</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cognition</term><term>Humans</term><term>Quality of Life</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and the globus pallidus pars interna (GPi) has been shown to be an effective treatment for patients with Parkinson's disease. Strong clinical evidence supports the improvement of motor and non-motor complications and quality of life, with some data suggesting that GPi DBS might be less effective than STN DBS. However, neither STN nor GPi stimulation provides a satisfactory control of non-dopaminergic symptoms, such as gait and balance impairment and cognitive decline, which are frequent and disabling symptoms in advanced Parkinson's disease patients. Therefore, several efforts have been made to discover alternative and new targets to overcome these current DBS limitations. Among these new targets, the stimulation of the pedunculopontine nucleus has initially appeared encouraging. However, findings from different double-blind trials have mitigated the enthusiasm. A multi-target strategy aimed at improving symptoms with different pathogenetic mechanisms might be a promising approach in the next years.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Grenoble</li></settlement></list><tree><noCountry><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name></noCountry><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Castrioto, Anna" sort="Castrioto, Anna" uniqKey="Castrioto A" first="Anna" last="Castrioto">Anna Castrioto</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001258 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 001258 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Ncbi
|étape= Checkpoint
|type= RBID
|clé= pubmed:24215284
|texte= New targets for deep brain stimulation treatment of Parkinson's disease.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:24215284" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |