Effect of subthalamic deep brain stimulation on non-motor fluctuations in Parkinson's disease.
Identifieur interne : 001036 ( Ncbi/Checkpoint ); précédent : 001035; suivant : 001037Effect of subthalamic deep brain stimulation on non-motor fluctuations in Parkinson's disease.
Auteurs : Jean-Philippe Azulay [France] ; Tatiana Witjas ; Alexandre EusebioSource :
- Journal of neural transmission (Vienna, Austria : 1996) [ 1435-1463 ] ; 2013.
English descriptors
- KwdEn :
- Autonomic Nervous System Diseases (complications), Autonomic Nervous System Diseases (therapy), Deep Brain Stimulation (methods), Depression (complications), Depression (therapy), Humans, Pain Management, Parkinson Disease (complications), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Subthalamic Nucleus (physiopathology).
- MESH :
- complications : Autonomic Nervous System Diseases, Depression, Parkinson Disease.
- methods : Deep Brain Stimulation.
- physiopathology : Parkinson Disease, Subthalamic Nucleus.
- therapy : Autonomic Nervous System Diseases, Depression, Parkinson Disease.
- Humans, Pain Management.
Abstract
The non-motor consequences of subthalamic stimulation are largely questioned. Cognition, motivation, anxiety, depression and even occurrence of suicides have been considered as a potential consequence of the surgical intervention. Non-motor fluctuations are present in all the patients with motor fluctuations and may sometimes be even more invalidating. Interestingly, subthalamic deep brain stimulation alleviates non-motor fluctuations allowing strikingly successful effects on sensory, dysautonomic and cognitive fluctuations while psychic fluctuations respond less consistently to this treatment. Nevertheless, severe mood fluctuations, oscillating from Off dysphoria to ON hypomania, are frequently associated with addictive behaviors and improve dramatically after subthalamic stimulation. This may be a further argument to support the indication of surgery for these patients.
DOI: 10.1007/s00702-012-0958-9
PubMed: 23263599
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000751
- to stream PubMed, to step Curation: 000718
- to stream PubMed, to step Checkpoint: 000718
- to stream Ncbi, to step Merge: 001036
- to stream Ncbi, to step Curation: 001036
Links to Exploration step
pubmed:23263599Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of subthalamic deep brain stimulation on non-motor fluctuations in Parkinson's disease.</title><author><name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean-Philippe" last="Azulay">Jean-Philippe Azulay</name><affiliation wicri:level="3"><nlm:affiliation>Service de Neurologie et Pathologie du Mouvement, Assistance Publique-Hôpitaux de Marseille et Aix-Marseille Universite, Hôpital de la Timone, 13385, Marseille cedex 05, France. jean-philippe.azulay@ap-hm.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie et Pathologie du Mouvement, Assistance Publique-Hôpitaux de Marseille et Aix-Marseille Universite, Hôpital de la Timone, 13385, Marseille cedex 05</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Witjas, Tatiana" sort="Witjas, Tatiana" uniqKey="Witjas T" first="Tatiana" last="Witjas">Tatiana Witjas</name></author><author><name sortKey="Eusebio, Alexandre" sort="Eusebio, Alexandre" uniqKey="Eusebio A" first="Alexandre" last="Eusebio">Alexandre Eusebio</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23263599</idno><idno type="pmid">23263599</idno><idno type="doi">10.1007/s00702-012-0958-9</idno><idno type="wicri:Area/PubMed/Corpus">000751</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000751</idno><idno type="wicri:Area/PubMed/Curation">000718</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000718</idno><idno type="wicri:Area/PubMed/Checkpoint">000718</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000718</idno><idno type="wicri:Area/Ncbi/Merge">001036</idno><idno type="wicri:Area/Ncbi/Curation">001036</idno><idno type="wicri:Area/Ncbi/Checkpoint">001036</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effect of subthalamic deep brain stimulation on non-motor fluctuations in Parkinson's disease.</title><author><name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean-Philippe" last="Azulay">Jean-Philippe Azulay</name><affiliation wicri:level="3"><nlm:affiliation>Service de Neurologie et Pathologie du Mouvement, Assistance Publique-Hôpitaux de Marseille et Aix-Marseille Universite, Hôpital de la Timone, 13385, Marseille cedex 05, France. jean-philippe.azulay@ap-hm.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie et Pathologie du Mouvement, Assistance Publique-Hôpitaux de Marseille et Aix-Marseille Universite, Hôpital de la Timone, 13385, Marseille cedex 05</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Witjas, Tatiana" sort="Witjas, Tatiana" uniqKey="Witjas T" first="Tatiana" last="Witjas">Tatiana Witjas</name></author><author><name sortKey="Eusebio, Alexandre" sort="Eusebio, Alexandre" uniqKey="Eusebio A" first="Alexandre" last="Eusebio">Alexandre Eusebio</name></author></analytic><series><title level="j">Journal of neural transmission (Vienna, Austria : 1996)</title><idno type="eISSN">1435-1463</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autonomic Nervous System Diseases (complications)</term><term>Autonomic Nervous System Diseases (therapy)</term><term>Deep Brain Stimulation (methods)</term><term>Depression (complications)</term><term>Depression (therapy)</term><term>Humans</term><term>Pain Management</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Subthalamic Nucleus (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Autonomic Nervous System Diseases</term><term>Depression</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Autonomic Nervous System Diseases</term><term>Depression</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Pain Management</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The non-motor consequences of subthalamic stimulation are largely questioned. Cognition, motivation, anxiety, depression and even occurrence of suicides have been considered as a potential consequence of the surgical intervention. Non-motor fluctuations are present in all the patients with motor fluctuations and may sometimes be even more invalidating. Interestingly, subthalamic deep brain stimulation alleviates non-motor fluctuations allowing strikingly successful effects on sensory, dysautonomic and cognitive fluctuations while psychic fluctuations respond less consistently to this treatment. Nevertheless, severe mood fluctuations, oscillating from Off dysphoria to ON hypomania, are frequently associated with addictive behaviors and improve dramatically after subthalamic stimulation. This may be a further argument to support the indication of surgery for these patients.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Marseille</li></settlement></list><tree><noCountry><name sortKey="Eusebio, Alexandre" sort="Eusebio, Alexandre" uniqKey="Eusebio A" first="Alexandre" last="Eusebio">Alexandre Eusebio</name><name sortKey="Witjas, Tatiana" sort="Witjas, Tatiana" uniqKey="Witjas T" first="Tatiana" last="Witjas">Tatiana Witjas</name></noCountry><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean-Philippe" last="Azulay">Jean-Philippe Azulay</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001036 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 001036 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Ncbi
|étape= Checkpoint
|type= RBID
|clé= pubmed:23263599
|texte= Effect of subthalamic deep brain stimulation on non-motor fluctuations in Parkinson's disease.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:23263599" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |