Effect of subthalamic deep brain stimulation on non-motor fluctuations in Parkinson's disease.
Identifieur interne : 001036 ( Ncbi/Checkpoint ); précédent : 001035; suivant : 001037Effect of subthalamic deep brain stimulation on non-motor fluctuations in Parkinson's disease.
Auteurs : Jean-Philippe Azulay [France] ; Tatiana Witjas ; Alexandre EusebioSource :
- Journal of neural transmission (Vienna, Austria : 1996) [ 1435-1463 ] ; 2013.
English descriptors
- KwdEn :
- Autonomic Nervous System Diseases (complications), Autonomic Nervous System Diseases (therapy), Deep Brain Stimulation (methods), Depression (complications), Depression (therapy), Humans, Pain Management, Parkinson Disease (complications), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Subthalamic Nucleus (physiopathology).
- MESH :
- complications : Autonomic Nervous System Diseases, Depression, Parkinson Disease.
- methods : Deep Brain Stimulation.
- physiopathology : Parkinson Disease, Subthalamic Nucleus.
- therapy : Autonomic Nervous System Diseases, Depression, Parkinson Disease.
- Humans, Pain Management.
Abstract
The non-motor consequences of subthalamic stimulation are largely questioned. Cognition, motivation, anxiety, depression and even occurrence of suicides have been considered as a potential consequence of the surgical intervention. Non-motor fluctuations are present in all the patients with motor fluctuations and may sometimes be even more invalidating. Interestingly, subthalamic deep brain stimulation alleviates non-motor fluctuations allowing strikingly successful effects on sensory, dysautonomic and cognitive fluctuations while psychic fluctuations respond less consistently to this treatment. Nevertheless, severe mood fluctuations, oscillating from Off dysphoria to ON hypomania, are frequently associated with addictive behaviors and improve dramatically after subthalamic stimulation. This may be a further argument to support the indication of surgery for these patients.
DOI: 10.1007/s00702-012-0958-9
PubMed: 23263599
Affiliations:
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pubmed:23263599Le document en format XML
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<front><div type="abstract" xml:lang="en">The non-motor consequences of subthalamic stimulation are largely questioned. Cognition, motivation, anxiety, depression and even occurrence of suicides have been considered as a potential consequence of the surgical intervention. Non-motor fluctuations are present in all the patients with motor fluctuations and may sometimes be even more invalidating. Interestingly, subthalamic deep brain stimulation alleviates non-motor fluctuations allowing strikingly successful effects on sensory, dysautonomic and cognitive fluctuations while psychic fluctuations respond less consistently to this treatment. Nevertheless, severe mood fluctuations, oscillating from Off dysphoria to ON hypomania, are frequently associated with addictive behaviors and improve dramatically after subthalamic stimulation. This may be a further argument to support the indication of surgery for these patients.</div>
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