Somatostatinergic systems: an update on brain functions in normal and pathological aging
Identifieur interne : 001029 ( Ncbi/Checkpoint ); précédent : 001028; suivant : 001030Somatostatinergic systems: an update on brain functions in normal and pathological aging
Auteurs : Guillaume Martel ; Patrick Dutar ; Jacques Epelbaum ; Cécile ViolletSource :
- Frontiers in Endocrinology [ 1664-2392 ] ; 2012.
Abstract
Somatostatin is highly expressed in mammalian brain and is involved in many brain functions such as motor activity, sleep, sensory, and cognitive processes. Five somatostatin receptors have been described: sst1, sst2 (A and B), sst3, sst4, and sst5, all belonging to the G-protein-coupled receptor family. During the recent years, numerous studies contributed to clarify the role of somatostatin systems, especially long-range somatostatinergic interneurons, in several functions they have been previously involved in. New advances have also been made on the alterations of somatostatinergic systems in several brain diseases and on the potential therapeutic target they represent in these pathologies.
Url:
DOI: 10.3389/fendo.2012.00154
PubMed: 23230430
PubMed Central: 3515867
Affiliations:
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<front><div type="abstract" xml:lang="en"><p>Somatostatin is highly expressed in mammalian brain and is involved in many brain functions such as motor activity, sleep, sensory, and cognitive processes. Five somatostatin receptors have been described: sst<sub>1</sub>
, sst<sub>2</sub>
(A and B), sst<sub>3</sub>
, sst<sub>4</sub>
, and sst<sub>5</sub>
, all belonging to the G-protein-coupled receptor family. During the recent years, numerous studies contributed to clarify the role of somatostatin systems, especially long-range somatostatinergic interneurons, in several functions they have been previously involved in. New advances have also been made on the alterations of somatostatinergic systems in several brain diseases and on the potential therapeutic target they represent in these pathologies.</p>
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<tree><noCountry><name sortKey="Dutar, Patrick" sort="Dutar, Patrick" uniqKey="Dutar P" first="Patrick" last="Dutar">Patrick Dutar</name>
<name sortKey="Epelbaum, Jacques" sort="Epelbaum, Jacques" uniqKey="Epelbaum J" first="Jacques" last="Epelbaum">Jacques Epelbaum</name>
<name sortKey="Martel, Guillaume" sort="Martel, Guillaume" uniqKey="Martel G" first="Guillaume" last="Martel">Guillaume Martel</name>
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