Perampanel in Parkinson disease fluctuations: a double-blind randomized trial with placebo and entacapone.
Identifieur interne : 000E33 ( Ncbi/Checkpoint ); précédent : 000E32; suivant : 000E34Perampanel in Parkinson disease fluctuations: a double-blind randomized trial with placebo and entacapone.
Auteurs : Olivier Rascol [France] ; Paolo Barone ; Madhuri Behari ; Murat Emre ; Nir Giladi ; C Warren Olanow ; Evzen Ruzicka ; Francesco Bibbiani ; David Squillacote ; Anna Patten ; Eduardo TolosaSource :
- Clinical neuropharmacology [ 1537-162X ]
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (adverse effects), Catechols (therapeutic use), Double-Blind Method, Dyskinesia, Drug-Induced (drug therapy), Dyskinesia, Drug-Induced (etiology), Enzyme Inhibitors (therapeutic use), Excitatory Amino Acid Antagonists (therapeutic use), Female, Humans, International Cooperation, Levodopa (adverse effects), Male, Middle Aged, Nitriles (therapeutic use), Parkinson Disease (drug therapy), Prospective Studies, Pyridones (therapeutic use), Severity of Illness Index, Treatment Outcome.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- chemical , therapeutic use : Catechols, Enzyme Inhibitors, Excitatory Amino Acid Antagonists, Nitriles, Pyridones.
- drug therapy : Dyskinesia, Drug-Induced, Parkinson Disease.
- etiology : Dyskinesia, Drug-Induced.
- Aged, Double-Blind Method, Female, Humans, International Cooperation, Male, Middle Aged, Prospective Studies, Severity of Illness Index, Treatment Outcome.
Abstract
Perampanel is a selective and noncompetitive α-amino-3-hydroxy-5-methylisoxazole propionic acid-type glutamate receptor antagonist that improves motor symptoms in animal models of Parkinson disease (PD). The aim of this study was to assess the efficacy and tolerability of perampanel in L-dopa-treated patients with moderately severe PD and motor fluctuations using an active comparator study design.
DOI: 10.1097/WNF.0b013e318241520b
PubMed: 22222634
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000898
- to stream PubMed, to step Curation: 000862
- to stream PubMed, to step Checkpoint: 000862
- to stream Ncbi, to step Merge: 000E33
- to stream Ncbi, to step Curation: 000E33
Links to Exploration step
pubmed:22222634Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Perampanel in Parkinson disease fluctuations: a double-blind randomized trial with placebo and entacapone.</title><author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><affiliation wicri:level="1"><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale Clinical Investigation Center, Toulouse University Hospital and University of Toulouse, France. olivier.rascol@univ-tlse3.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale Clinical Investigation Center, Toulouse University Hospital and University of Toulouse</wicri:regionArea><wicri:noRegion>Toulouse University Hospital and University of Toulouse</wicri:noRegion><wicri:noRegion>Toulouse University Hospital and University of Toulouse</wicri:noRegion></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name></author><author><name sortKey="Behari, Madhuri" sort="Behari, Madhuri" uniqKey="Behari M" first="Madhuri" last="Behari">Madhuri Behari</name></author><author><name sortKey="Emre, Murat" sort="Emre, Murat" uniqKey="Emre M" first="Murat" last="Emre">Murat Emre</name></author><author><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name></author><author><name sortKey="Olanow, C Warren" sort="Olanow, C Warren" uniqKey="Olanow C" first="C Warren" last="Olanow">C Warren Olanow</name></author><author><name sortKey="Ruzicka, Evzen" sort="Ruzicka, Evzen" uniqKey="Ruzicka E" first="Evzen" last="Ruzicka">Evzen Ruzicka</name></author><author><name sortKey="Bibbiani, Francesco" sort="Bibbiani, Francesco" uniqKey="Bibbiani F" first="Francesco" last="Bibbiani">Francesco Bibbiani</name></author><author><name sortKey="Squillacote, David" sort="Squillacote, David" uniqKey="Squillacote D" first="David" last="Squillacote">David Squillacote</name></author><author><name sortKey="Patten, Anna" sort="Patten, Anna" uniqKey="Patten A" first="Anna" last="Patten">Anna Patten</name></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2012 Jan-Feb</MedlineDate></PubDate></date><idno type="RBID">pubmed:22222634</idno><idno type="pmid">22222634</idno><idno type="doi">10.1097/WNF.0b013e318241520b</idno><idno type="wicri:Area/PubMed/Corpus">000898</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000898</idno><idno type="wicri:Area/PubMed/Curation">000862</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000862</idno><idno type="wicri:Area/PubMed/Checkpoint">000862</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000862</idno><idno type="wicri:Area/Ncbi/Merge">000E33</idno><idno type="wicri:Area/Ncbi/Curation">000E33</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E33</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Perampanel in Parkinson disease fluctuations: a double-blind randomized trial with placebo and entacapone.</title><author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><affiliation wicri:level="1"><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale Clinical Investigation Center, Toulouse University Hospital and University of Toulouse, France. olivier.rascol@univ-tlse3.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale Clinical Investigation Center, Toulouse University Hospital and University of Toulouse</wicri:regionArea><wicri:noRegion>Toulouse University Hospital and University of Toulouse</wicri:noRegion><wicri:noRegion>Toulouse University Hospital and University of Toulouse</wicri:noRegion></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name></author><author><name sortKey="Behari, Madhuri" sort="Behari, Madhuri" uniqKey="Behari M" first="Madhuri" last="Behari">Madhuri Behari</name></author><author><name sortKey="Emre, Murat" sort="Emre, Murat" uniqKey="Emre M" first="Murat" last="Emre">Murat Emre</name></author><author><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name></author><author><name sortKey="Olanow, C Warren" sort="Olanow, C Warren" uniqKey="Olanow C" first="C Warren" last="Olanow">C Warren Olanow</name></author><author><name sortKey="Ruzicka, Evzen" sort="Ruzicka, Evzen" uniqKey="Ruzicka E" first="Evzen" last="Ruzicka">Evzen Ruzicka</name></author><author><name sortKey="Bibbiani, Francesco" sort="Bibbiani, Francesco" uniqKey="Bibbiani F" first="Francesco" last="Bibbiani">Francesco Bibbiani</name></author><author><name sortKey="Squillacote, David" sort="Squillacote, David" uniqKey="Squillacote D" first="David" last="Squillacote">David Squillacote</name></author><author><name sortKey="Patten, Anna" sort="Patten, Anna" uniqKey="Patten A" first="Anna" last="Patten">Anna Patten</name></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name></author></analytic><series><title level="j">Clinical neuropharmacology</title><idno type="eISSN">1537-162X</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antiparkinson Agents (adverse effects)</term><term>Catechols (therapeutic use)</term><term>Double-Blind Method</term><term>Dyskinesia, Drug-Induced (drug therapy)</term><term>Dyskinesia, Drug-Induced (etiology)</term><term>Enzyme Inhibitors (therapeutic use)</term><term>Excitatory Amino Acid Antagonists (therapeutic use)</term><term>Female</term><term>Humans</term><term>International Cooperation</term><term>Levodopa (adverse effects)</term><term>Male</term><term>Middle Aged</term><term>Nitriles (therapeutic use)</term><term>Parkinson Disease (drug therapy)</term><term>Prospective Studies</term><term>Pyridones (therapeutic use)</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Catechols</term><term>Enzyme Inhibitors</term><term>Excitatory Amino Acid Antagonists</term><term>Nitriles</term><term>Pyridones</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dyskinesia, Drug-Induced</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>International Cooperation</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Perampanel is a selective and noncompetitive α-amino-3-hydroxy-5-methylisoxazole propionic acid-type glutamate receptor antagonist that improves motor symptoms in animal models of Parkinson disease (PD). The aim of this study was to assess the efficacy and tolerability of perampanel in L-dopa-treated patients with moderately severe PD and motor fluctuations using an active comparator study design.</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><name sortKey="Behari, Madhuri" sort="Behari, Madhuri" uniqKey="Behari M" first="Madhuri" last="Behari">Madhuri Behari</name><name sortKey="Bibbiani, Francesco" sort="Bibbiani, Francesco" uniqKey="Bibbiani F" first="Francesco" last="Bibbiani">Francesco Bibbiani</name><name sortKey="Emre, Murat" sort="Emre, Murat" uniqKey="Emre M" first="Murat" last="Emre">Murat Emre</name><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name><name sortKey="Olanow, C Warren" sort="Olanow, C Warren" uniqKey="Olanow C" first="C Warren" last="Olanow">C Warren Olanow</name><name sortKey="Patten, Anna" sort="Patten, Anna" uniqKey="Patten A" first="Anna" last="Patten">Anna Patten</name><name sortKey="Ruzicka, Evzen" sort="Ruzicka, Evzen" uniqKey="Ruzicka E" first="Evzen" last="Ruzicka">Evzen Ruzicka</name><name sortKey="Squillacote, David" sort="Squillacote, David" uniqKey="Squillacote D" first="David" last="Squillacote">David Squillacote</name><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name></noCountry><country name="France"><noRegion><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E33 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 000E33 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Ncbi
|étape= Checkpoint
|type= RBID
|clé= pubmed:22222634
|texte= Perampanel in Parkinson disease fluctuations: a double-blind randomized trial with placebo and entacapone.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:22222634" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |