Perampanel in Parkinson disease fluctuations: a double-blind randomized trial with placebo and entacapone.
Identifieur interne : 000E33 ( Ncbi/Checkpoint ); précédent : 000E32; suivant : 000E34Perampanel in Parkinson disease fluctuations: a double-blind randomized trial with placebo and entacapone.
Auteurs : Olivier Rascol [France] ; Paolo Barone ; Madhuri Behari ; Murat Emre ; Nir Giladi ; C Warren Olanow ; Evzen Ruzicka ; Francesco Bibbiani ; David Squillacote ; Anna Patten ; Eduardo TolosaSource :
- Clinical neuropharmacology [ 1537-162X ]
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (adverse effects), Catechols (therapeutic use), Double-Blind Method, Dyskinesia, Drug-Induced (drug therapy), Dyskinesia, Drug-Induced (etiology), Enzyme Inhibitors (therapeutic use), Excitatory Amino Acid Antagonists (therapeutic use), Female, Humans, International Cooperation, Levodopa (adverse effects), Male, Middle Aged, Nitriles (therapeutic use), Parkinson Disease (drug therapy), Prospective Studies, Pyridones (therapeutic use), Severity of Illness Index, Treatment Outcome.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- chemical , therapeutic use : Catechols, Enzyme Inhibitors, Excitatory Amino Acid Antagonists, Nitriles, Pyridones.
- drug therapy : Dyskinesia, Drug-Induced, Parkinson Disease.
- etiology : Dyskinesia, Drug-Induced.
- Aged, Double-Blind Method, Female, Humans, International Cooperation, Male, Middle Aged, Prospective Studies, Severity of Illness Index, Treatment Outcome.
Abstract
Perampanel is a selective and noncompetitive α-amino-3-hydroxy-5-methylisoxazole propionic acid-type glutamate receptor antagonist that improves motor symptoms in animal models of Parkinson disease (PD). The aim of this study was to assess the efficacy and tolerability of perampanel in L-dopa-treated patients with moderately severe PD and motor fluctuations using an active comparator study design.
DOI: 10.1097/WNF.0b013e318241520b
PubMed: 22222634
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000898
- to stream PubMed, to step Curation: 000862
- to stream PubMed, to step Checkpoint: 000862
- to stream Ncbi, to step Merge: 000E33
- to stream Ncbi, to step Curation: 000E33
Links to Exploration step
pubmed:22222634Le document en format XML
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<front><div type="abstract" xml:lang="en">Perampanel is a selective and noncompetitive α-amino-3-hydroxy-5-methylisoxazole propionic acid-type glutamate receptor antagonist that improves motor symptoms in animal models of Parkinson disease (PD). The aim of this study was to assess the efficacy and tolerability of perampanel in L-dopa-treated patients with moderately severe PD and motor fluctuations using an active comparator study design.</div>
</front>
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<tree><noCountry><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name>
<name sortKey="Behari, Madhuri" sort="Behari, Madhuri" uniqKey="Behari M" first="Madhuri" last="Behari">Madhuri Behari</name>
<name sortKey="Bibbiani, Francesco" sort="Bibbiani, Francesco" uniqKey="Bibbiani F" first="Francesco" last="Bibbiani">Francesco Bibbiani</name>
<name sortKey="Emre, Murat" sort="Emre, Murat" uniqKey="Emre M" first="Murat" last="Emre">Murat Emre</name>
<name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name>
<name sortKey="Olanow, C Warren" sort="Olanow, C Warren" uniqKey="Olanow C" first="C Warren" last="Olanow">C Warren Olanow</name>
<name sortKey="Patten, Anna" sort="Patten, Anna" uniqKey="Patten A" first="Anna" last="Patten">Anna Patten</name>
<name sortKey="Ruzicka, Evzen" sort="Ruzicka, Evzen" uniqKey="Ruzicka E" first="Evzen" last="Ruzicka">Evzen Ruzicka</name>
<name sortKey="Squillacote, David" sort="Squillacote, David" uniqKey="Squillacote D" first="David" last="Squillacote">David Squillacote</name>
<name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name>
</noCountry>
<country name="France"><noRegion><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name>
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