Does ageing aggravate parkinsonian disability?
Identifieur interne : 000A20 ( Ncbi/Checkpoint ); précédent : 000A19; suivant : 000A21Does ageing aggravate parkinsonian disability?
Auteurs : J. Blin ; B. Dubois ; A M Bonnet ; M. Vidailhet ; M. Brandabur ; Yves Agid [France]Source :
- Journal of Neurology, Neurosurgery, and Psychiatry [ 0022-3050 ] ; 1991.
English descriptors
- KwdEn :
- Age Factors, Aged, Disability Evaluation, Female, Humans, Levodopa (therapeutic use), Male, Middle Aged, Motor Neurons (drug effects), Motor Neurons (physiology), Muscles (innervation), Neurologic Examination, Parkinson Disease (diagnosis), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Retrospective Studies.
- MESH :
- chemical , therapeutic use : Levodopa.
- diagnosis : Parkinson Disease.
- drug effects : Motor Neurons.
- drug therapy : Parkinson Disease.
- innervation : Muscles.
- physiology : Motor Neurons.
- physiopathology : Parkinson Disease.
- Age Factors, Aged, Disability Evaluation, Female, Humans, Male, Middle Aged, Neurologic Examination, Retrospective Studies.
Abstract
The influence of age of onset of Parkinson's disease on the severity and the pattern of motor symptoms was investigated by comparing the motor scores with and without levodopa therapy in two groups of patients divided according to age of onset (early less than 50, late greater than 60 years) and matched for disease duration (n = 69 in each group, Study I). The baseline score, that is, the motor disability of patients when off levodopa, was similar in the early- and late- onset groups. In contrast, the residual motor score, assessed when the effect of levodopa treatment was maximum and stable, was significantly higher in the late onset group. When the two groups of patients were matched, in addition, for their residual motor score, (n = 54 in each group, Study II), no difference was observed between the early and late onset groups, except for gait disorder which was more severe in older patients. These results suggest that age of onset mainly affects the response to levodopa therapy, because it may increase the prevalence of non-dopaminergic lesions of the brain, including those responsible for gait disorders.
Url:
PubMed: 1955894
PubMed Central: 1014515
Affiliations:
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PMC:1014515Le document en format XML
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Brandabur</name></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">1955894</idno><idno type="pmc">1014515</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1014515</idno><idno type="RBID">PMC:1014515</idno><date when="1991">1991</date><idno type="wicri:Area/Pmc/Corpus">000278</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000278</idno><idno type="wicri:Area/Pmc/Curation">000276</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000276</idno><idno type="wicri:Area/Pmc/Checkpoint">000979</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000979</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001786</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001786</idno><idno type="wicri:Area/PubMed/Curation">001745</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001745</idno><idno type="wicri:Area/PubMed/Checkpoint">001745</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001745</idno><idno type="wicri:Area/Ncbi/Merge">000A20</idno><idno type="wicri:Area/Ncbi/Curation">000A20</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A20</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Does ageing aggravate parkinsonian disability?</title><author><name sortKey="Blin, J" sort="Blin, J" uniqKey="Blin J" first="J" last="Blin">J. Blin</name></author><author><name sortKey="Dubois, B" sort="Dubois, B" uniqKey="Dubois B" first="B" last="Dubois">B. Dubois</name></author><author><name sortKey="Bonnet, A M" sort="Bonnet, A M" uniqKey="Bonnet A" first="A M" last="Bonnet">A M Bonnet</name></author><author><name sortKey="Vidailhet, M" sort="Vidailhet, M" uniqKey="Vidailhet M" first="M" last="Vidailhet">M. Vidailhet</name></author><author><name sortKey="Brandabur, M" sort="Brandabur, M" uniqKey="Brandabur M" first="M" last="Brandabur">M. Brandabur</name></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author></analytic><series><title level="j">Journal of Neurology, Neurosurgery, and Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><date when="1991">1991</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Disability Evaluation</term><term>Female</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Motor Neurons (drug effects)</term><term>Motor Neurons (physiology)</term><term>Muscles (innervation)</term><term>Neurologic Examination</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Retrospective Studies</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Motor Neurons</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Muscles</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Motor Neurons</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Disability Evaluation</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Retrospective Studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The influence of age of onset of Parkinson's disease on the severity and the pattern of motor symptoms was investigated by comparing the motor scores with and without levodopa therapy in two groups of patients divided according to age of onset (early less than 50, late greater than 60 years) and matched for disease duration (n = 69 in each group, Study I). The baseline score, that is, the motor disability of patients when off levodopa, was similar in the early- and late- onset groups. In contrast, the residual motor score, assessed when the effect of levodopa treatment was maximum and stable, was significantly higher in the late onset group. When the two groups of patients were matched, in addition, for their residual motor score, (n = 54 in each group, Study II), no difference was observed between the early and late onset groups, except for gait disorder which was more severe in older patients. These results suggest that age of onset mainly affects the response to levodopa therapy, because it may increase the prevalence of non-dopaminergic lesions of the brain, including those responsible for gait disorders.</p></div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement><orgName><li>Hôpital de la Salpêtrière</li></orgName></list><tree><noCountry><name sortKey="Blin, J" sort="Blin, J" uniqKey="Blin J" first="J" last="Blin">J. Blin</name><name sortKey="Bonnet, A M" sort="Bonnet, A M" uniqKey="Bonnet A" first="A M" last="Bonnet">A M Bonnet</name><name sortKey="Brandabur, M" sort="Brandabur, M" uniqKey="Brandabur M" first="M" last="Brandabur">M. Brandabur</name><name sortKey="Dubois, B" sort="Dubois, B" uniqKey="Dubois B" first="B" last="Dubois">B. Dubois</name><name sortKey="Vidailhet, M" sort="Vidailhet, M" uniqKey="Vidailhet M" first="M" last="Vidailhet">M. Vidailhet</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Yves Agid</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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