Changes to interneuron-driven striatal microcircuits in a rat model of Parkinson's disease.
Identifieur interne : 000988 ( Ncbi/Checkpoint ); précédent : 000987; suivant : 000989Changes to interneuron-driven striatal microcircuits in a rat model of Parkinson's disease.
Auteurs : Pascal Salin [France] ; Iciar P. L Pez ; Philippe Kachidian ; Pedro Barroso-Chinea ; Alberto J. Rico ; Virginia G Mez-Bautista ; Patrice Coulon ; Lydia Kerkerian-Le Goff ; José L. LanciegoSource :
- Neurobiology of disease [ 1095-953X ] ; 2009.
English descriptors
- KwdEn :
- Animals, Calbindin 2, Cell Count, Choline O-Acetyltransferase (metabolism), Densitometry, Disease Models, Animal, Globus Pallidus (physiopathology), Immunohistochemistry, Interneurons (physiology), Male, Nitric Oxide Synthase Type I (metabolism), Oxidopamine, Parkinson Disease (physiopathology), Parvalbumins (metabolism), Rabies virus, Rats, Rats, Wistar, S100 Calcium Binding Protein G (metabolism), Substantia Nigra (physiopathology).
- MESH :
- chemical , metabolism : Choline O-Acetyltransferase, Nitric Oxide Synthase Type I, Parvalbumins, S100 Calcium Binding Protein G.
- chemical : Calbindin 2, Oxidopamine.
- physiology : Interneurons.
- physiopathology : Globus Pallidus, Parkinson Disease, Substantia Nigra.
- Animals, Cell Count, Densitometry, Disease Models, Animal, Immunohistochemistry, Male, Rabies virus, Rats, Rats, Wistar.
Abstract
Striatal interneurons play key roles in basal ganglia function and related disorders by modulating the activity of striatal projection neurons. Here we have injected rabies virus (RV) into either the rat substantia nigra pars reticulata or the globus pallidus and took advantage of the trans-synaptic spread of RV to unequivocally identify the interneurons connected to striatonigral- or striatopallidal-projecting neurons, respectively. Large numbers of RV-infected parvalbumin (PV+/RV+) and cholinergic (ChAT+/RV+) interneurons were detected in control conditions, and they showed marked changes following intranigral 6-hydroxydopamine injection. The number of ChAT+/RV+ interneurons innervating striatopallidal neurons increased concomitant with a reduction in the number of PV+/RV+ interneurons, while the two interneuron populations connected to striatonigral neurons were clearly reduced. These data provide the first evidence of synaptic reorganization between striatal interneurons and projection neurons, notably a switch of cholinergic innervation onto striatopallidal neurons, which could contribute to imbalanced striatal outflow in parkinsonian state.
DOI: 10.1016/j.nbd.2009.03.006
PubMed: 19341798
Affiliations:
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Rico</name></author><author><name sortKey="G Mez Bautista, Virginia" sort="G Mez Bautista, Virginia" uniqKey="G Mez Bautista V" first="Virginia" last="G Mez-Bautista">Virginia G Mez-Bautista</name></author><author><name sortKey="Coulon, Patrice" sort="Coulon, Patrice" uniqKey="Coulon P" first="Patrice" last="Coulon">Patrice Coulon</name></author><author><name sortKey="Kerkerian Le Goff, Lydia" sort="Kerkerian Le Goff, Lydia" uniqKey="Kerkerian Le Goff L" first="Lydia" last="Kerkerian-Le Goff">Lydia Kerkerian-Le Goff</name></author><author><name sortKey="Lanciego, Jose L" sort="Lanciego, Jose L" uniqKey="Lanciego J" first="José L" last="Lanciego">José L. 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Here we have injected rabies virus (RV) into either the rat substantia nigra pars reticulata or the globus pallidus and took advantage of the trans-synaptic spread of RV to unequivocally identify the interneurons connected to striatonigral- or striatopallidal-projecting neurons, respectively. Large numbers of RV-infected parvalbumin (PV+/RV+) and cholinergic (ChAT+/RV+) interneurons were detected in control conditions, and they showed marked changes following intranigral 6-hydroxydopamine injection. The number of ChAT+/RV+ interneurons innervating striatopallidal neurons increased concomitant with a reduction in the number of PV+/RV+ interneurons, while the two interneuron populations connected to striatonigral neurons were clearly reduced. These data provide the first evidence of synaptic reorganization between striatal interneurons and projection neurons, notably a switch of cholinergic innervation onto striatopallidal neurons, which could contribute to imbalanced striatal outflow in parkinsonian state.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Marseille</li></settlement><orgName><li>Université de la Méditerranée</li></orgName></list><tree><noCountry><name sortKey="Barroso Chinea, Pedro" sort="Barroso Chinea, Pedro" uniqKey="Barroso Chinea P" first="Pedro" last="Barroso-Chinea">Pedro Barroso-Chinea</name><name sortKey="Coulon, Patrice" sort="Coulon, Patrice" uniqKey="Coulon P" first="Patrice" last="Coulon">Patrice Coulon</name><name sortKey="G Mez Bautista, Virginia" sort="G Mez Bautista, Virginia" uniqKey="G Mez Bautista V" first="Virginia" last="G Mez-Bautista">Virginia G Mez-Bautista</name><name sortKey="Kachidian, Philippe" sort="Kachidian, Philippe" uniqKey="Kachidian P" first="Philippe" last="Kachidian">Philippe Kachidian</name><name sortKey="Kerkerian Le Goff, Lydia" sort="Kerkerian Le Goff, Lydia" uniqKey="Kerkerian Le Goff L" first="Lydia" last="Kerkerian-Le Goff">Lydia Kerkerian-Le Goff</name><name sortKey="L Pez, Iciar P" sort="L Pez, Iciar P" uniqKey="L Pez I" first="Iciar P" last="L Pez">Iciar P. L Pez</name><name sortKey="Lanciego, Jose L" sort="Lanciego, Jose L" uniqKey="Lanciego J" first="José L" last="Lanciego">José L. Lanciego</name><name sortKey="Rico, Alberto J" sort="Rico, Alberto J" uniqKey="Rico A" first="Alberto J" last="Rico">Alberto J. Rico</name></noCountry><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Salin, Pascal" sort="Salin, Pascal" uniqKey="Salin P" first="Pascal" last="Salin">Pascal Salin</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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