Does subthalamic nucleus stimulation affect the frontal limbic areas? A single-photon emission computed tomography study using a manual anatomical segmentation method.
Identifieur interne : 000550 ( Ncbi/Checkpoint ); précédent : 000549; suivant : 000551Does subthalamic nucleus stimulation affect the frontal limbic areas? A single-photon emission computed tomography study using a manual anatomical segmentation method.
Auteurs : C. Haegelen [France] ; M. Verin ; B Aubert Broche ; F. Prigent ; P. Jannin ; B. Gibaud ; X. MorandiSource :
- Surgical and radiologic anatomy : SRA [ 0930-1038 ] ; 2005.
English descriptors
- KwdEn :
- Antiparkinson Agents (therapeutic use), Cerebrovascular Circulation (physiology), Cognition (physiology), Deep Brain Stimulation, Female, Frontal Lobe (physiopathology), Gyrus Cinguli (physiopathology), Humans, Image Processing, Computer-Assisted (methods), Imaging, Three-Dimensional (methods), Levodopa (therapeutic use), Limbic System (physiopathology), Magnetic Resonance Imaging (methods), Male, Middle Aged, Neural Pathways (physiopathology), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Prefrontal Cortex (physiopathology), Prospective Studies, Subthalamic Nucleus (physiopathology), Tomography, Emission-Computed, Single-Photon (methods).
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- methods : Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Tomography, Emission-Computed, Single-Photon.
- physiology : Cerebrovascular Circulation, Cognition.
- physiopathology : Frontal Lobe, Gyrus Cinguli, Limbic System, Neural Pathways, Parkinson Disease, Prefrontal Cortex, Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Deep Brain Stimulation, Female, Humans, Male, Middle Aged, Prospective Studies.
Abstract
Among the basal ganglia nuclei, the subthalamic nucleus (STN) is considered to play a major role in output modulation. The STN represents a relay of the motor cortico-basal ganglia-thalamo-cortical circuit and has become the standard surgical target for treating Parkinson's patients with long-term motor fluctuations and dyskinesia. But chronic bilateral stimulation of the STN produces cognitive effects. According to animal and clinical studies, the STN also appears to have direct or indirect connections with the frontal associative and limbic areas. This prospective study was conducted to analyse regional cerebral blood flow changes in single-photon emission computed tomography imaging of six Parkinson's patients before and after STN stimulation. We particularly focused on the dorsolateral prefrontal cortex and the frontal limbic areas using a manual anatomical MRI segmentation method. We defined nine regions of interest, segmenting each MR slice to quantify the regional cerebral blood flow on pre- and postoperative SPECT images. We normalised the region-of-interest-based measurements to the entire brain volume. The patients showed increased activation during STN stimulation in the dorsolateral prefrontal cortex bilaterally and no change in the anterior cingulate and orbito-frontal cortices. In our study, STN stimulation induced activation of premotor and associative frontal areas. Further studies are needed to underline involvement of the STN with the so-called limbic system.
DOI: 10.1007/s00276-005-0021-8
PubMed: 16160830
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000F22
- to stream PubMed, to step Curation: 000E82
- to stream PubMed, to step Checkpoint: 000E82
- to stream Ncbi, to step Merge: 000550
- to stream Ncbi, to step Curation: 000550
Links to Exploration step
pubmed:16160830Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Does subthalamic nucleus stimulation affect the frontal limbic areas? A single-photon emission computed tomography study using a manual anatomical segmentation method.</title><author><name sortKey="Haegelen, C" sort="Haegelen, C" uniqKey="Haegelen C" first="C" last="Haegelen">C. Haegelen</name><affiliation wicri:level="3"><nlm:affiliation>Service de Neurochirurgie, Hôpital Pontchaillou, rue Henri Le Guilloux, 35033, Rennes cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurochirurgie, Hôpital Pontchaillou, rue Henri Le Guilloux, 35033, Rennes cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Verin, M" sort="Verin, M" uniqKey="Verin M" first="M" last="Verin">M. Verin</name></author><author><name sortKey="Broche, B Aubert" sort="Broche, B Aubert" uniqKey="Broche B" first="B Aubert" last="Broche">B Aubert Broche</name></author><author><name sortKey="Prigent, F" sort="Prigent, F" uniqKey="Prigent F" first="F" last="Prigent">F. Prigent</name></author><author><name sortKey="Jannin, P" sort="Jannin, P" uniqKey="Jannin P" first="P" last="Jannin">P. Jannin</name></author><author><name sortKey="Gibaud, B" sort="Gibaud, B" uniqKey="Gibaud B" first="B" last="Gibaud">B. Gibaud</name></author><author><name sortKey="Morandi, X" sort="Morandi, X" uniqKey="Morandi X" first="X" last="Morandi">X. Morandi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="RBID">pubmed:16160830</idno><idno type="pmid">16160830</idno><idno type="doi">10.1007/s00276-005-0021-8</idno><idno type="wicri:Area/PubMed/Corpus">000F22</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F22</idno><idno type="wicri:Area/PubMed/Curation">000E82</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E82</idno><idno type="wicri:Area/PubMed/Checkpoint">000E82</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000E82</idno><idno type="wicri:Area/Ncbi/Merge">000550</idno><idno type="wicri:Area/Ncbi/Curation">000550</idno><idno type="wicri:Area/Ncbi/Checkpoint">000550</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Does subthalamic nucleus stimulation affect the frontal limbic areas? A single-photon emission computed tomography study using a manual anatomical segmentation method.</title><author><name sortKey="Haegelen, C" sort="Haegelen, C" uniqKey="Haegelen C" first="C" last="Haegelen">C. Haegelen</name><affiliation wicri:level="3"><nlm:affiliation>Service de Neurochirurgie, Hôpital Pontchaillou, rue Henri Le Guilloux, 35033, Rennes cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurochirurgie, Hôpital Pontchaillou, rue Henri Le Guilloux, 35033, Rennes cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Verin, M" sort="Verin, M" uniqKey="Verin M" first="M" last="Verin">M. Verin</name></author><author><name sortKey="Broche, B Aubert" sort="Broche, B Aubert" uniqKey="Broche B" first="B Aubert" last="Broche">B Aubert Broche</name></author><author><name sortKey="Prigent, F" sort="Prigent, F" uniqKey="Prigent F" first="F" last="Prigent">F. Prigent</name></author><author><name sortKey="Jannin, P" sort="Jannin, P" uniqKey="Jannin P" first="P" last="Jannin">P. Jannin</name></author><author><name sortKey="Gibaud, B" sort="Gibaud, B" uniqKey="Gibaud B" first="B" last="Gibaud">B. Gibaud</name></author><author><name sortKey="Morandi, X" sort="Morandi, X" uniqKey="Morandi X" first="X" last="Morandi">X. Morandi</name></author></analytic><series><title level="j">Surgical and radiologic anatomy : SRA</title><idno type="ISSN">0930-1038</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiparkinson Agents (therapeutic use)</term><term>Cerebrovascular Circulation (physiology)</term><term>Cognition (physiology)</term><term>Deep Brain Stimulation</term><term>Female</term><term>Frontal Lobe (physiopathology)</term><term>Gyrus Cinguli (physiopathology)</term><term>Humans</term><term>Image Processing, Computer-Assisted (methods)</term><term>Imaging, Three-Dimensional (methods)</term><term>Levodopa (therapeutic use)</term><term>Limbic System (physiopathology)</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Middle Aged</term><term>Neural Pathways (physiopathology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Prefrontal Cortex (physiopathology)</term><term>Prospective Studies</term><term>Subthalamic Nucleus (physiopathology)</term><term>Tomography, Emission-Computed, Single-Photon (methods)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Image Processing, Computer-Assisted</term><term>Imaging, Three-Dimensional</term><term>Magnetic Resonance Imaging</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cerebrovascular Circulation</term><term>Cognition</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Frontal Lobe</term><term>Gyrus Cinguli</term><term>Limbic System</term><term>Neural Pathways</term><term>Parkinson Disease</term><term>Prefrontal Cortex</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Deep Brain Stimulation</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Among the basal ganglia nuclei, the subthalamic nucleus (STN) is considered to play a major role in output modulation. The STN represents a relay of the motor cortico-basal ganglia-thalamo-cortical circuit and has become the standard surgical target for treating Parkinson's patients with long-term motor fluctuations and dyskinesia. But chronic bilateral stimulation of the STN produces cognitive effects. According to animal and clinical studies, the STN also appears to have direct or indirect connections with the frontal associative and limbic areas. This prospective study was conducted to analyse regional cerebral blood flow changes in single-photon emission computed tomography imaging of six Parkinson's patients before and after STN stimulation. We particularly focused on the dorsolateral prefrontal cortex and the frontal limbic areas using a manual anatomical MRI segmentation method. We defined nine regions of interest, segmenting each MR slice to quantify the regional cerebral blood flow on pre- and postoperative SPECT images. We normalised the region-of-interest-based measurements to the entire brain volume. The patients showed increased activation during STN stimulation in the dorsolateral prefrontal cortex bilaterally and no change in the anterior cingulate and orbito-frontal cortices. In our study, STN stimulation induced activation of premotor and associative frontal areas. Further studies are needed to underline involvement of the STN with the so-called limbic system.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Région Bretagne</li></region><settlement><li>Rennes</li></settlement></list><tree><noCountry><name sortKey="Broche, B Aubert" sort="Broche, B Aubert" uniqKey="Broche B" first="B Aubert" last="Broche">B Aubert Broche</name><name sortKey="Gibaud, B" sort="Gibaud, B" uniqKey="Gibaud B" first="B" last="Gibaud">B. Gibaud</name><name sortKey="Jannin, P" sort="Jannin, P" uniqKey="Jannin P" first="P" last="Jannin">P. Jannin</name><name sortKey="Morandi, X" sort="Morandi, X" uniqKey="Morandi X" first="X" last="Morandi">X. Morandi</name><name sortKey="Prigent, F" sort="Prigent, F" uniqKey="Prigent F" first="F" last="Prigent">F. Prigent</name><name sortKey="Verin, M" sort="Verin, M" uniqKey="Verin M" first="M" last="Verin">M. Verin</name></noCountry><country name="France"><region name="Région Bretagne"><name sortKey="Haegelen, C" sort="Haegelen, C" uniqKey="Haegelen C" first="C" last="Haegelen">C. Haegelen</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000550 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 000550 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Ncbi
|étape= Checkpoint
|type= RBID
|clé= pubmed:16160830
|texte= Does subthalamic nucleus stimulation affect the frontal limbic areas? A single-photon emission computed tomography study using a manual anatomical segmentation method.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:16160830" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |