Neuroendocrinology of neurodegenerative diseases. Insights from transgenic mouse models.
Identifieur interne : 000397 ( Ncbi/Checkpoint ); précédent : 000396; suivant : 000398Neuroendocrinology of neurodegenerative diseases. Insights from transgenic mouse models.
Auteurs : Jose-Luis González De Aguilar [France] ; Frédérique René ; Luc Dupuis ; Jean-Philippe LoefflerSource :
- Neuroendocrinology [ 0028-3835 ] ; 2003.
English descriptors
- KwdEn :
- Alzheimer Disease (metabolism), Amyotrophic Lateral Sclerosis (metabolism), Animals, Disease Models, Animal, Humans, Neurodegenerative Diseases (metabolism), Neurodegenerative Diseases (physiopathology), Neurosecretory Systems (metabolism), Neurosecretory Systems (physiopathology), Parkinson Disease (metabolism).
- MESH :
- metabolism : Alzheimer Disease, Amyotrophic Lateral Sclerosis, Neurodegenerative Diseases, Neurosecretory Systems, Parkinson Disease.
- physiopathology : Neurodegenerative Diseases, Neurosecretory Systems.
- Animals, Disease Models, Animal, Humans.
Abstract
The nervous system plays a key role in the regulation of neuroendocrine axes and, in turn, the released neurohormones modulate the activity of different brain regions. Neurodegenerative diseases, which are known to affect specific neuronal populations, may provoke neuroendocrine dysfunctions that alter the intimate relationship between both systems. In addition, these modifications may influence the progression of the neurodegenerative process. In the present review, we summarise some of the endocrine changes characterising three major neurodegenerative diseases: Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Special attention is focused on the contribution of disease transgenic models to elucidate such alterations.
DOI: 74445
PubMed: 14657605
Affiliations:
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pubmed:14657605Le document en format XML
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Insights from transgenic mouse models.</title><author><name sortKey="Gonzalez De Aguilar, Jose Luis" sort="Gonzalez De Aguilar, Jose Luis" uniqKey="Gonzalez De Aguilar J" first="Jose-Luis" last="González De Aguilar">Jose-Luis González De Aguilar</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire de Signalisations Moléculaires et Neurodégénérescence, EA 3433, Université Louis-Pasteur, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Signalisations Moléculaires et Neurodégénérescence, EA 3433, Université Louis-Pasteur, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName><orgName type="university">Université Strasbourg 1</orgName></affiliation></author><author><name sortKey="Rene, Frederique" sort="Rene, Frederique" uniqKey="Rene F" first="Frédérique" last="René">Frédérique René</name></author><author><name sortKey="Dupuis, Luc" sort="Dupuis, Luc" uniqKey="Dupuis L" first="Luc" last="Dupuis">Luc Dupuis</name></author><author><name sortKey="Loeffler, Jean Philippe" sort="Loeffler, Jean Philippe" uniqKey="Loeffler J" first="Jean-Philippe" last="Loeffler">Jean-Philippe Loeffler</name></author></analytic><series><title level="j">Neuroendocrinology</title><idno type="ISSN">0028-3835</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer Disease (metabolism)</term><term>Amyotrophic Lateral Sclerosis (metabolism)</term><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term><term>Neurodegenerative Diseases (metabolism)</term><term>Neurodegenerative Diseases (physiopathology)</term><term>Neurosecretory Systems (metabolism)</term><term>Neurosecretory Systems (physiopathology)</term><term>Parkinson Disease (metabolism)</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Alzheimer Disease</term><term>Amyotrophic Lateral Sclerosis</term><term>Neurodegenerative Diseases</term><term>Neurosecretory Systems</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Neurodegenerative Diseases</term><term>Neurosecretory Systems</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The nervous system plays a key role in the regulation of neuroendocrine axes and, in turn, the released neurohormones modulate the activity of different brain regions. Neurodegenerative diseases, which are known to affect specific neuronal populations, may provoke neuroendocrine dysfunctions that alter the intimate relationship between both systems. In addition, these modifications may influence the progression of the neurodegenerative process. In the present review, we summarise some of the endocrine changes characterising three major neurodegenerative diseases: Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. 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