Dopaminergic function and dopamine transporter binding assessed with positron emission tomography in Parkinson disease.
Identifieur interne : 000233 ( Ncbi/Checkpoint ); précédent : 000232; suivant : 000234Dopaminergic function and dopamine transporter binding assessed with positron emission tomography in Parkinson disease.
Auteurs : Maria-Joao Ribeiro [France] ; Marie Vidailhet ; Christian Loc'H ; Corinne Dupel ; Jean Paul Nguyen ; Michel Ponchant ; Frédéric Dollé ; Marc Peschanski ; Philippe Hantraye ; Pierre Cesaro ; Yves Samson ; Philippe RemySource :
- Archives of neurology [ 0003-9942 ] ; 2002.
English descriptors
- KwdEn :
- Aged, Case-Control Studies, Corpus Striatum (metabolism), Dopamine (metabolism), Dopamine Plasma Membrane Transport Proteins, Female, Humans, Male, Membrane Glycoproteins, Membrane Transport Proteins (metabolism), Middle Aged, Nerve Tissue Proteins (metabolism), Parkinson Disease (diagnostic imaging), Parkinson Disease (metabolism), Tomography, Emission-Computed.
- MESH :
- chemical , metabolism : Dopamine, Membrane Transport Proteins, Nerve Tissue Proteins.
- diagnostic imaging : Parkinson Disease.
- metabolism : Corpus Striatum, Parkinson Disease.
- Aged, Case-Control Studies, Dopamine Plasma Membrane Transport Proteins, Female, Humans, Male, Membrane Glycoproteins, Middle Aged, Tomography, Emission-Computed.
Abstract
Measuring progression of Parkinson disease (PD) using positron emission tomography may help demonstrate the efficacy of neuroprotective treatments. To date, (18)F-dopa has been the gold standard to measure presynaptic dopaminergic function in PD, but this tracer might overestimate the rate of neuronal death in PD because its uptake also depends on dopamine turnover rather than exclusively on the density of dopaminergic terminals in the striatum. The latter might be assessed using newly developed ligands of the membrane dopamine transporter.
PubMed: 11939892
Affiliations:
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pubmed:11939892Le document en format XML
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<front><div type="abstract" xml:lang="en">Measuring progression of Parkinson disease (PD) using positron emission tomography may help demonstrate the efficacy of neuroprotective treatments. To date, (18)F-dopa has been the gold standard to measure presynaptic dopaminergic function in PD, but this tracer might overestimate the rate of neuronal death in PD because its uptake also depends on dopamine turnover rather than exclusively on the density of dopaminergic terminals in the striatum. The latter might be assessed using newly developed ligands of the membrane dopamine transporter.</div>
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<name sortKey="Dolle, Frederic" sort="Dolle, Frederic" uniqKey="Dolle F" first="Frédéric" last="Dollé">Frédéric Dollé</name>
<name sortKey="Dupel, Corinne" sort="Dupel, Corinne" uniqKey="Dupel C" first="Corinne" last="Dupel">Corinne Dupel</name>
<name sortKey="Hantraye, Philippe" sort="Hantraye, Philippe" uniqKey="Hantraye P" first="Philippe" last="Hantraye">Philippe Hantraye</name>
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<name sortKey="Nguyen, Jean Paul" sort="Nguyen, Jean Paul" uniqKey="Nguyen J" first="Jean Paul" last="Nguyen">Jean Paul Nguyen</name>
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<name sortKey="Ponchant, Michel" sort="Ponchant, Michel" uniqKey="Ponchant M" first="Michel" last="Ponchant">Michel Ponchant</name>
<name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name>
<name sortKey="Samson, Yves" sort="Samson, Yves" uniqKey="Samson Y" first="Yves" last="Samson">Yves Samson</name>
<name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name>
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