Chemical and pharmacological aspects of heteroaryl-nitrones.
Identifieur interne : 000142 ( Ncbi/Checkpoint ); précédent : 000141; suivant : 000143Chemical and pharmacological aspects of heteroaryl-nitrones.
Auteurs : S. Goldstein [France] ; P. LestageSource :
- Current medicinal chemistry [ 0929-8673 ] ; 2000.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Nitrogen Oxides.
- chemical , pharmacology : Nitrogen Oxides.
Abstract
Radical induced oxidative damage is extremely harmful to tissues and organs due to molecular modifications brought to polyunsaturated membrane lipids, proteins and nucleic acids. Oxidative stress is believed to be one of the pathophysiological mechanisms that operate in neurodegenerative disorders such as cerebral ischemias, amyotrophic lateral sclerosis, Parkinson s and Alzheimer s diseases. Nitrones oppose oxidative challenges by virtue of their ability to trap very rapidly oxygen or carbon centered radicals thus generating nitroxide radical species which are more stable and biochemically less harmful than the original radical. However the operational mechanism of nitrones might also go beyond direct scavenging of radicals. The chemical and pharmacological properties of nitrones depend strongly on the connectivity as well as on the type and position of the substituents in the compound's architecture. Heteroaryl-nitrones are known, but except for a few cases (for example pyridyl-nitrones) no particular attention has been given to this class of molecules. The following review is a survey of the literature reports on this subject from 1980 to 1999. The structures were classified according to the heterocyclic substituent on the nitrone double bond, and documented pharmaceutical features were emphasized. Whenever possible heteroaromatic and related aromatic nitrones were compared.
PubMed: 11032970
Affiliations:
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Goldstein</name><affiliation wicri:level="3"><nlm:affiliation>Institut de Recherches Servier Chemistry Research Division A, 11 rue des Moulineaux, Suresnes, 92150, France. sgoldst@netgrs.com</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut de Recherches Servier Chemistry Research Division A, 11 rue des Moulineaux, Suresnes, 92150</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Lestage, P" sort="Lestage, P" uniqKey="Lestage P" first="P" last="Lestage">P. Lestage</name></author></analytic><series><title level="j">Current medicinal chemistry</title><idno type="ISSN">0929-8673</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Nitrogen Oxides (chemistry)</term><term>Nitrogen Oxides (pharmacology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Nitrogen Oxides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Nitrogen Oxides</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Radical induced oxidative damage is extremely harmful to tissues and organs due to molecular modifications brought to polyunsaturated membrane lipids, proteins and nucleic acids. Oxidative stress is believed to be one of the pathophysiological mechanisms that operate in neurodegenerative disorders such as cerebral ischemias, amyotrophic lateral sclerosis, Parkinson s and Alzheimer s diseases. Nitrones oppose oxidative challenges by virtue of their ability to trap very rapidly oxygen or carbon centered radicals thus generating nitroxide radical species which are more stable and biochemically less harmful than the original radical. However the operational mechanism of nitrones might also go beyond direct scavenging of radicals. The chemical and pharmacological properties of nitrones depend strongly on the connectivity as well as on the type and position of the substituents in the compound's architecture. Heteroaryl-nitrones are known, but except for a few cases (for example pyridyl-nitrones) no particular attention has been given to this class of molecules. The following review is a survey of the literature reports on this subject from 1980 to 1999. The structures were classified according to the heterocyclic substituent on the nitrone double bond, and documented pharmaceutical features were emphasized. Whenever possible heteroaromatic and related aromatic nitrones were compared.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region></list><tree><noCountry><name sortKey="Lestage, P" sort="Lestage, P" uniqKey="Lestage P" first="P" last="Lestage">P. Lestage</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Goldstein, S" sort="Goldstein, S" uniqKey="Goldstein S" first="S" last="Goldstein">S. Goldstein</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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