Study of circadian melatonin secretion pattern at different stages of Parkinson's disease.
Identifieur interne : 006481 ( Main/Merge ); précédent : 006480; suivant : 006482Study of circadian melatonin secretion pattern at different stages of Parkinson's disease.
Auteurs : R. Bordet [France] ; D. Devos ; S. Brique ; Y. Touitou ; J D Guieu ; C. Libersa ; A. DestéeSource :
- Clinical neuropharmacology [ 0362-5664 ]
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Hydrocortisone, Melatonin.
- blood : Parkinson Disease.
- physiology : Circadian Rhythm.
- physiopathology : Parkinson Disease.
- chemical , secretion : Melatonin.
- Aged, Area Under Curve, Female, Humans, Male, Middle Aged, Statistics, Nonparametric.
Abstract
To explore changes in melatonin secretion patterns and biologic rhythms in Parkinson's disease patients with or without levodopa-related motor complications (LDRMCs), the authors investigated, in an observational study, circadian rhythms of central temperature, motor activity, plasma cortisol, and melatonin in three groups: de novo untreated patients (group I), patients treated with levodopa + dopamine agonist and without LDRMCs (group II), and patients treated with levodopa + dopamine agonist and with LDRMCs (group III). There were no differences among the three groups for the rhythm of temperature, motor activity, or plasma cortisol. There was a significant (p < 0.05) phase advance in plasma melatonin secretion in patients receiving a dopaminergic treatment compared with untreated patients. The daytime area under the curve (AUC) was increased significantly in group III, and the nighttime AUC-to-daytime AUC ratio of melatonin secretion decreased significantly in group III, suggesting that the nychthemeral pattern of melatonin secretion was changed in patients with LDRMCs. Comparison of the three groups suggests a slight but insignificant phase advance and amplitude decrease of circadian melatonin secretion related to both evolution and treatment of Parkinson's disease. Despite the lack of a global desynchronization in other circadian biologic rhythms, the circadian secretion pattern of melatonin is modified in patients with LDRMCs.
PubMed: 12671525
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pubmed:12671525Le document en format XML
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Devos</name></author><author><name sortKey="Brique, S" sort="Brique, S" uniqKey="Brique S" first="S" last="Brique">S. Brique</name></author><author><name sortKey="Touitou, Y" sort="Touitou, Y" uniqKey="Touitou Y" first="Y" last="Touitou">Y. Touitou</name></author><author><name sortKey="Guieu, J D" sort="Guieu, J D" uniqKey="Guieu J" first="J D" last="Guieu">J D Guieu</name></author><author><name sortKey="Libersa, C" sort="Libersa, C" uniqKey="Libersa C" first="C" last="Libersa">C. Libersa</name></author><author><name sortKey="Destee, A" sort="Destee, A" uniqKey="Destee A" first="A" last="Destée">A. 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Bordet</name><affiliation wicri:level="3"><nlm:affiliation>Service de Pharmacologie Hospitalière, Laboratoire de Pharmacologie, Faculté de Médecine, 1 place de Verdun, 59045 Lille Cedex, France. r-bordet@chru-lille.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Pharmacologie Hospitalière, Laboratoire de Pharmacologie, Faculté de Médecine, 1 place de Verdun, 59045 Lille Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Devos, D" sort="Devos, D" uniqKey="Devos D" first="D" last="Devos">D. Devos</name></author><author><name sortKey="Brique, S" sort="Brique, S" uniqKey="Brique S" first="S" last="Brique">S. Brique</name></author><author><name sortKey="Touitou, Y" sort="Touitou, Y" uniqKey="Touitou Y" first="Y" last="Touitou">Y. Touitou</name></author><author><name sortKey="Guieu, J D" sort="Guieu, J D" uniqKey="Guieu J" first="J D" last="Guieu">J D Guieu</name></author><author><name sortKey="Libersa, C" sort="Libersa, C" uniqKey="Libersa C" first="C" last="Libersa">C. Libersa</name></author><author><name sortKey="Destee, A" sort="Destee, A" uniqKey="Destee A" first="A" last="Destée">A. 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There were no differences among the three groups for the rhythm of temperature, motor activity, or plasma cortisol. There was a significant (p < 0.05) phase advance in plasma melatonin secretion in patients receiving a dopaminergic treatment compared with untreated patients. The daytime area under the curve (AUC) was increased significantly in group III, and the nighttime AUC-to-daytime AUC ratio of melatonin secretion decreased significantly in group III, suggesting that the nychthemeral pattern of melatonin secretion was changed in patients with LDRMCs. Comparison of the three groups suggests a slight but insignificant phase advance and amplitude decrease of circadian melatonin secretion related to both evolution and treatment of Parkinson's disease. Despite the lack of a global desynchronization in other circadian biologic rhythms, the circadian secretion pattern of melatonin is modified in patients with LDRMCs.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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